Journal of Pharmacology and Experimental Therapeutics: 381 (2)

May 01, 2022; Volume 381,Issue 2

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Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model
Yukinori Nagakura

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 106-119; DOI: https://doi.org/10.1124/jpet.121.001051
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Therapeutic Basis of Generic Substitution of Antiseizure Medications
Sarah Elmer and Doodipala Samba Reddy

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 188-196; DOI: https://doi.org/10.1124/jpet.121.000994

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High Salt Upregulates Ca²⁺-Sensing Receptor Expression and Ca²⁺-Induced Relaxation of Contracted Mesenteric Arteries from Dahl Salt-Sensitive Rats
Lakeesha E. Bridges, Cicely L. Williams and Emmanuel M. Awumey

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 120-128; DOI: https://doi.org/10.1124/jpet.121.001034

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Insulin Enhances Gene Expression of Midnolin, a Novel Genetic Risk Factor for Parkinson’s Disease, via Extracellular Signal-Regulated Kinase, Phosphoinositide 3-Kinase and Multiple Transcription Factors in SH-SY5Y Cells
Naoki Sagehashi, Yutaro Obara, Ohki Maruyama, Tadashi Nakagawa, Toru Hosoi and Kuniaki Ishii

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 68-78; DOI: https://doi.org/10.1124/jpet.121.001076
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Targeting Mitochondrial Large-Conductance Calcium-Activated Potassium Channel by Hydrogen Sulfide via Heme-Binding Site
Agnieszka Walewska, Adam Szewczyk, Milena Krajewska and Piotr Koprowski

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 137-150; DOI: https://doi.org/10.1124/jpet.121.001017
Open Access
ML355 Modulates Platelet Activation and Prevents ABT-737 Induced Apoptosis in Platelets
Valentina Shpakova, Natalia Rukoyatkina, Nada Al Arawe, Anna Prilepskaya, Alexandra Kharazova, Iraida Sharina, Stepan Gambaryan and Emil Martin

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 164-175; DOI: https://doi.org/10.1124/jpet.121.000973

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Pharmacological Profiling of Antifentanyl Monoclonal Antibodies in Combination with Naloxone in Pre- and Postexposure Models of Fentanyl Toxicity
Carly A. Baehr, Mariah M. Wu, Sujata G. Pandit, Jose Arias-Umana, David AuCoin and Marco Pravetoni

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 129-136; DOI: https://doi.org/10.1124/jpet.121.001048

Open Access
Resveratrol Attenuates High-Fat Diet–Induced Hepatic Lipotoxicity by Upregulating Bmi-1 Expression
Weigang Yuan, Mi Zhang, Chunxu Wang, Bin Li, Lei Li, Feng Ye and Chuanrui Xu

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 96-105; DOI: https://doi.org/10.1124/jpet.121.001018
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Inhibition of Full Smooth Muscle Contraction in Isolated Human Detrusor Tissues by Mirabegron Is Limited to Off-Target Inhibition of Neurogenic Contractions
Ru Huang, Alexander Tamalunas, Raphaela Waidelich, Frank Strittmatter, Christian G. Stief and Martin Hennenberg

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 176-187; DOI: https://doi.org/10.1124/jpet.121.001029

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Pharmacokinetic/Pharmacodynamic Assessment of Selective Phosphodiesterase Inhibitors in a Mouse Model of Autoimmune Hepatitis
Artur Świerczek, Bartosz Pomierny, Elżbieta Wyska and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 151-163; DOI: https://doi.org/10.1124/jpet.121.001004

Open Access
Efficacy of Vesicular Monoamine Transporter 2 Inhibition and Synergy with Antipsychotics in Animal Models of Schizophrenia
Samuel R. J. Hoare, Andrea E. Kudwa, Rosa Luo and Dimitri E. Grigoriadis

Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 79-95; DOI: https://doi.org/10.1124/jpet.121.000979