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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

May 01, 2022; Volume 381,Issue 2

Minireview

  • You have access
    Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model
    Yukinori Nagakura
    Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 106-119; DOI: https://doi.org/10.1124/jpet.121.001051
  • You have access
    Therapeutic Basis of Generic Substitution of Antiseizure Medications
    Sarah Elmer and Doodipala Samba Reddy
    Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 188-196; DOI: https://doi.org/10.1124/jpet.121.000994

Cardiovascular

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    High Salt Upregulates Ca2+-Sensing Receptor Expression and Ca2+-Induced Relaxation of Contracted Mesenteric Arteries from Dahl Salt-Sensitive Rats
    Lakeesha E. Bridges, Cicely L. Williams and Emmanuel M. Awumey
    Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 120-128; DOI: https://doi.org/10.1124/jpet.121.001034

Cellular and Molecular

  • You have access
    Insulin Enhances Gene Expression of Midnolin, a Novel Genetic Risk Factor for Parkinson’s Disease, via Extracellular Signal-Regulated Kinase, Phosphoinositide 3-Kinase and Multiple Transcription Factors in SH-SY5Y Cells
    Naoki Sagehashi, Yutaro Obara, Ohki Maruyama, Tadashi Nakagawa, Toru Hosoi and Kuniaki Ishii
    Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 68-78; DOI: https://doi.org/10.1124/jpet.121.001076
  • You have access
    Targeting Mitochondrial Large-Conductance Calcium-Activated Potassium Channel by Hydrogen Sulfide via Heme-Binding Site
    Agnieszka Walewska, Adam Szewczyk, Milena Krajewska and Piotr Koprowski
    Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 137-150; DOI: https://doi.org/10.1124/jpet.121.001017
  • ML355 Modulates Platelet Activation and Prevents ABT-737 Induced Apoptosis in Platelets
    Open Access
    ML355 Modulates Platelet Activation and Prevents ABT-737 Induced Apoptosis in Platelets
    Valentina Shpakova, Natalia Rukoyatkina, Nada Al Arawe, Anna Prilepskaya, Alexandra Kharazova, Iraida Sharina, Stepan Gambaryan and Emil Martin
    Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 164-175; DOI: https://doi.org/10.1124/jpet.121.000973

Drug Discovery and Translational Medicine

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    Pharmacological Profiling of Antifentanyl Monoclonal Antibodies in Combination with Naloxone in Pre- and Postexposure Models of Fentanyl Toxicity
    Carly A. Baehr, Mariah M. Wu, Sujata G. Pandit, Jose Arias-Umana, David AuCoin and Marco Pravetoni
    Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 129-136; DOI: https://doi.org/10.1124/jpet.121.001048

Gastrointestinal, Hepatic, Pulmonary, and Renal

  • Resveratrol Attenuates High-Fat Diet–Induced Hepatic Lipotoxicity by Upregulating Bmi-1 Expression
    Open Access
    Resveratrol Attenuates High-Fat Diet–Induced Hepatic Lipotoxicity by Upregulating Bmi-1 Expression
    Weigang Yuan, Mi Zhang, Chunxu Wang, Bin Li, Lei Li, Feng Ye and Chuanrui Xu
    Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 96-105; DOI: https://doi.org/10.1124/jpet.121.001018
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    Inhibition of Full Smooth Muscle Contraction in Isolated Human Detrusor Tissues by Mirabegron Is Limited to Off-Target Inhibition of Neurogenic Contractions
    Ru Huang, Alexander Tamalunas, Raphaela Waidelich, Frank Strittmatter, Christian G. Stief and Martin Hennenberg
    Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 176-187; DOI: https://doi.org/10.1124/jpet.121.001029

Inflammation, Immunopharmacology, and Asthma

  • Pharmacokinetic/Pharmacodynamic Assessment of Selective Phosphodiesterase Inhibitors in a Mouse Model of Autoimmune Hepatitis
    You have access
    Pharmacokinetic/Pharmacodynamic Assessment of Selective Phosphodiesterase Inhibitors in a Mouse Model of Autoimmune Hepatitis
    Artur Świerczek, Bartosz Pomierny, Elżbieta Wyska and William J. Jusko
    Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 151-163; DOI: https://doi.org/10.1124/jpet.121.001004

Neuropharmacology

  • Efficacy of Vesicular Monoamine Transporter 2 Inhibition and Synergy with Antipsychotics in Animal Models of Schizophrenia
    Open Access
    Efficacy of Vesicular Monoamine Transporter 2 Inhibition and Synergy with Antipsychotics in Animal Models of Schizophrenia
    Samuel R. J. Hoare, Andrea E. Kudwa, Rosa Luo and Dimitri E. Grigoriadis
    Journal of Pharmacology and Experimental Therapeutics May 2022, 381 (2) 79-95; DOI: https://doi.org/10.1124/jpet.121.000979
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 381 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 381, Issue 2
1 May 2022
  • Table of Contents
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  • Minireview
  • Cardiovascular
  • Cellular and Molecular
  • Drug Discovery and Translational Medicine
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Neuropharmacology
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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