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Table of Contents

April 01, 2022; Volume 381,Issue 1

Minireview

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Attenuation of Response to Repeated Drug Administration: A Proposal for Differentiating Tachyphylaxis and Tolerance
Craig K. Svensson

Journal of Pharmacology and Experimental Therapeutics April 2022, 381 (1) 22-32; DOI: https://doi.org/10.1124/jpet.121.000978

Cellular and Molecular

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Cinnabarinic Acid-Induced Stanniocalcin 2 Confers Cytoprotection against Alcohol-Induced Liver Injury
Aditya D. Joshi, Gopal Thinakaran and Cornelis Elferink

Journal of Pharmacology and Experimental Therapeutics April 2022, 381 (1) 1-11; DOI: https://doi.org/10.1124/jpet.121.000999

Chemotherapy, Antibiotics, and Gene Therapy

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Inhibition of Colon Cancer Cell Growth by Phosphodiesterase Inhibitors Is Independent of cGMP Signaling
Yali Hou, Alexis Wren, Namratha Mylarapu, Kaylin Browning, Bianca N. Islam, Rui Wang, Kenneth J. Vega and Darren D. Browning

Journal of Pharmacology and Experimental Therapeutics April 2022, 381 (1) 42-53; DOI: https://doi.org/10.1124/jpet.121.001075

Drug Discovery and Translational Medicine

Open Access
A Phase I, First-in-Human, Healthy Volunteer Study to Investigate the Safety, Tolerability, and Pharmacokinetics of CVN424, a Novel G Protein-Coupled Receptor 6 Inverse Agonist for Parkinson’s Disease
David H. Margolin, Nicola L. Brice, Antonia M. Davidson, Kim L. Matthews and Mark B. L. Carlton

Journal of Pharmacology and Experimental Therapeutics April 2022, 381 (1) 33-41; DOI: https://doi.org/10.1124/jpet.121.000842

Inflammation, Immunopharmacology, and Asthma

Open Access
Preclinical Immunopharmacologic Assessment of KPL-404, a Novel, Humanized, Non-Depleting Antagonistic Anti-CD40 Monoclonal Antibody
Sujatha Muralidharan, Moses Njenga, Tracy Garron, Kent Bondensgaard and John F. Paolini

Journal of Pharmacology and Experimental Therapeutics April 2022, 381 (1) 12-21; DOI: https://doi.org/10.1124/jpet.121.000881

Neuropharmacology

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Opportunities for Precision Treatment of GRIN2A and GRIN2B Gain-of-Function Variants in Triheteromeric N-Methyl-D-Aspartate Receptors
Wei Han, Hongjie Yuan, James P. Allen, Sukhan Kim, Gil H. Shaulsky, Riley E. Perszyk, Stephen F. Traynelis and Scott J. Myers

Journal of Pharmacology and Experimental Therapeutics April 2022, 381 (1) 54-66; DOI: https://doi.org/10.1124/jpet.121.001000

Erratum

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Correction to “Central Nervous System Distribution of an Opioid Agonist Combination with Synergistic Activity”
Journal of Pharmacology and Experimental Therapeutics April 2022, 381 (1) 67; DOI: https://doi.org/10.1124/jpet.121.000821err