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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

March 01, 2022; Volume 380,Issue 3

Behavioral Pharmacology

  • You have access
    Characterization of the Discriminative Stimulus Effects of Binary Mixtures of Mu Opioid Receptor Agonists in Rats Discriminating Fentanyl
    Shawn M. Flynn and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 171-179; DOI: https://doi.org/10.1124/jpet.121.000912

Cellular and Molecular

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    The Skeletal Muscle Relaxer Cyclobenzaprine Is a Potent Non-Competitive Antagonist of Histamine H1 Receptors
    Kirti Singh, Ilya S. Senatorov, Ameneh Cheshmehkani, Priyanka F. Karmokar and Nader H. Moniri
    Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 202-209; DOI: https://doi.org/10.1124/jpet.121.000998

Drug Discovery and Translational Medicine

  • You have access
    RTICBM-74 Is a Brain-Penetrant Cannabinoid Receptor Subtype 1 Allosteric Modulator that Reduces Alcohol Intake in Rats
    Dennis F. Lovelock, Thuy Nguyen, Kalynn Van Voorhies, Yanan Zhang and Joyce Besheer
    Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 153-161; DOI: https://doi.org/10.1124/jpet.121.000919
  • Open Access
    Pharmacokinetics and Safety Studies in Rodent Models Support Development of EPICERTIN as a Novel Topical Wound-Healing Biologic for Ulcerative Colitis
    Daniel Tusé, Micaela Reeves, Joshua Royal, Krystal T. Hamorsky, Hanna Ng, Maria Arolfo, Carol Green, Abhishek Trigunaite, Toufan Parman, Goo Lee and Nobuyuki Matoba
    Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 162-170; DOI: https://doi.org/10.1124/jpet.121.000904
  • You have access
    The Andrographolide Analogue 3A.1 Synergizes with Taxane Derivatives in Aggressive Metastatic Prostate Cancers by Upregulation of Heat Shock Proteins and Downregulation of MAT2A-Mediated Cell Migration and Invasion
    Taraswi Mitra Ghosh, Teeratas Kansom, Suman Mazumder, Joshua Davis, Ahmed S. Alnaim, Shanese L. Jasper, Chu Zhang, Aedan Bird, Praneet Opanasopit, Amit K. Mitra and Robert D. Arnold
    Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 180-201; DOI: https://doi.org/10.1124/jpet.121.000898
  • Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease
    Open Access
    Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease
    Patricia Schroeder, Keertik Fulzele, Sanjeev Forsyth, Maria D. Ribadeneira, Sylvie Guichard, Erik Wilker, C. Gary Marshall, Adam Drake, Rose Fessler, Diamantis G. Konstantinidis, Katie G. Seu and Theodosia A. Kalfa
    Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 210-219; DOI: https://doi.org/10.1124/jpet.121.000743
  • You have access
    A Potent Inhibitor of Aminopeptidase P2 Reduces Reperfusion Injury in Models of Myocardial Infarction and Stroke
    Morgan R. Lenz, Shih-Yen Tsai, Anne E. Roessler, Yang Wang, Periannan Sethupathi, W. Keith Jones, Gwendolyn L. Kartje and William H. Simmons
    Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 220-229; DOI: https://doi.org/10.1124/jpet.121.000875

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Empagliflozin Protects against Pulmonary Ischemia/Reperfusion Injury via an Extracellular Signal-Regulated Kinases 1 and 2-Dependent Mechanism
    Dou Huang, Feng Ju, Lei Du, Ting Liu, Yunxia Zuo, Geoffrey W. Abbott and Zhaoyang Hu
    Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 230-241; DOI: https://doi.org/10.1124/jpet.121.000956

Neuropharmacology

  • Open Access
    The Dopamine D1 Receptor Positive Allosteric Modulator Mevidalen (LY3154207) Enhances Wakefulness in the Humanized D1 Mouse and in Sleep-Deprived Healthy Male Volunteers
    Andrew P. McCarthy, Kjell A. Svensson, Elaine Shanks, Claire Brittain, Brian J. Eastwood, William Kielbasa, Kevin M. Biglan and Keith A. Wafford
    Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 143-152; DOI: https://doi.org/10.1124/jpet.121.000719
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 380 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 380, Issue 3
1 Mar 2022
  • Table of Contents
  • Table of Contents (PDF)
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  • Behavioral Pharmacology
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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