Table of Contents

Drug Discovery and Translational Medicine

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  RTICBM-74 Is a Brain-Penetrant Cannabinoid Receptor Subtype 1 Allosteric Modulator that Reduces Alcohol Intake in Rats

  Dennis F. Lovelock, Thuy Nguyen, Kalynn Van Voorhies, Yanan Zhang and Joyce Besheer

  Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 153-161; DOI: https://doi.org/10.1124/jpet.121.000919
• Open Access

  Pharmacokinetics and Safety Studies in Rodent Models Support Development of EPICERTIN as a Novel Topical Wound-Healing Biologic for Ulcerative Colitis

  Daniel Tusé, Micaela Reeves, Joshua Royal, Krystal T. Hamorsky, Hanna Ng, Maria Arolfo, Carol Green, Abhishek Trigunaite, Toufan Parman, Goo Lee and Nobuyuki Matoba

  Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 162-170; DOI: https://doi.org/10.1124/jpet.121.000904
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  The Andrographolide Analogue 3A.1 Synergizes with Taxane Derivatives in Aggressive Metastatic Prostate Cancers by Upregulation of Heat Shock Proteins and Downregulation of MAT2A-Mediated Cell Migration and Invasion

  Taraswi Mitra Ghosh, Teeratas Kansom, Suman Mazumder, Joshua Davis, Ahmed S. Alnaim, Shanese L. Jasper, Chu Zhang, Aedan Bird, Praneet Opanasopit, Amit K. Mitra and Robert D. Arnold

  Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 180-201; DOI: https://doi.org/10.1124/jpet.121.000898
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  Open Access

  Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease

  Patricia Schroeder, Keertik Fulzele, Sanjeev Forsyth, Maria D. Ribadeneira, Sylvie Guichard, Erik Wilker, C. Gary Marshall, Adam Drake, Rose Fessler, Diamantis G. Konstantinidis, Katie G. Seu and Theodosia A. Kalfa

  Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 210-219; DOI: https://doi.org/10.1124/jpet.121.000743
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  A Potent Inhibitor of Aminopeptidase P2 Reduces Reperfusion Injury in Models of Myocardial Infarction and Stroke

  Morgan R. Lenz, Shih-Yen Tsai, Anne E. Roessler, Yang Wang, Periannan Sethupathi, W. Keith Jones, Gwendolyn L. Kartje and William H. Simmons

  Journal of Pharmacology and Experimental Therapeutics March 2022, 380 (3) 220-229; DOI: https://doi.org/10.1124/jpet.121.000875