Research ArticleDrug Discovery and Translational Medicine
Novel Platform for Predicting Drug Effects in Patients with Acromegaly: Translational Exposure-Response Evaluation of Growth Hormone–Inhibitory Effect of Octreotide after Growth Hormone–Releasing Hormone Stimulation
Hiroyuki Iida, Tatsuya Komagata, Hirotaka Tanaka, Ryusuke Nagasawa, Takuya Nishio, Tomoyuki Shono, Junsaku Kitagawa, Ken-ichi Ogawara, Koji Shinozaki, Akiteru Seki, Mark Bruce and Tomoya Ohno
Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 400-408; DOI: https://doi.org/10.1124/jpet.121.000769
Hiroyuki Iida
Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)
Tatsuya Komagata
Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)
Hirotaka Tanaka
Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)
Ryusuke Nagasawa
Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)
Takuya Nishio
Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)
Tomoyuki Shono
Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)
Junsaku Kitagawa
Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)
Ken-ichi Ogawara
Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)
Koji Shinozaki
Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)
Akiteru Seki
Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)
Mark Bruce
Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)
Tomoya Ohno
Ono Pharmaceutical Co., Ltd., Osaka, Japan (H.I., T.K., H.T., R.N., T.N., T.S., J.K., K.S., A.S., T.O.); Laboratory of Pharmaceutics, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan (H.I., K.O.); and Ono Pharma UK Ltd., London, United Kingdom (M.B.)
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In this issue
Research ArticleDrug Discovery and Translational Medicine
Relationship between Octreotide Exposure and GH Inhibition
Hiroyuki Iida, Tatsuya Komagata, Hirotaka Tanaka, Ryusuke Nagasawa, Takuya Nishio, Tomoyuki Shono, Junsaku Kitagawa, Ken-ichi Ogawara, Koji Shinozaki, Akiteru Seki, Mark Bruce and Tomoya Ohno
Journal of Pharmacology and Experimental Therapeutics December 1, 2021, 379 (3) 400-408; DOI: https://doi.org/10.1124/jpet.121.000769
Research ArticleDrug Discovery and Translational Medicine
Relationship between Octreotide Exposure and GH Inhibition
Hiroyuki Iida, Tatsuya Komagata, Hirotaka Tanaka, Ryusuke Nagasawa, Takuya Nishio, Tomoyuki Shono, Junsaku Kitagawa, Ken-ichi Ogawara, Koji Shinozaki, Akiteru Seki, Mark Bruce and Tomoya Ohno
Journal of Pharmacology and Experimental Therapeutics December 1, 2021, 379 (3) 400-408; DOI: https://doi.org/10.1124/jpet.121.000769
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