Research ArticleDrug Discovery and Translational Medicine
Open Access
Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2–Depleted Splice Variant of Aminoacyl–Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70
Dae Gyu Kim, Srigouri Huddar, Semi Lim, Jiwon Kong, Yuno Lee, Chul Min Park, Seungbeom Lee, Young-Ger Suh, Minkyoung Kim, Kyeong Lee, Sunkyung Lee and Sunghoon Kim
Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 358-371; DOI: https://doi.org/10.1124/jpet.121.000766
Dae Gyu Kim
Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, Korea (D.G.K., S.Li., J.K., S.K.); Drug Information Research Center (S.H., Y.L., Su.Le.) and Center for Convergent Emerging Virus Infection (C.M.P.), Korea Research Institute of Chemical Technology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea (S.H., C.M.P., Su.Le.); College of Pharmacy, Cha University, Gyeonggi-do, Korea (Se.Le., Y.-G.S.); College of Pharmacy, Seoul National University, Seoul, Korea (Y.-G.S.); College of Pharmacy, Dongguk University, Goyang, Korea (M.K., K.L.)
Srigouri Huddar
Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, Korea (D.G.K., S.Li., J.K., S.K.); Drug Information Research Center (S.H., Y.L., Su.Le.) and Center for Convergent Emerging Virus Infection (C.M.P.), Korea Research Institute of Chemical Technology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea (S.H., C.M.P., Su.Le.); College of Pharmacy, Cha University, Gyeonggi-do, Korea (Se.Le., Y.-G.S.); College of Pharmacy, Seoul National University, Seoul, Korea (Y.-G.S.); College of Pharmacy, Dongguk University, Goyang, Korea (M.K., K.L.)
Semi Lim
Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, Korea (D.G.K., S.Li., J.K., S.K.); Drug Information Research Center (S.H., Y.L., Su.Le.) and Center for Convergent Emerging Virus Infection (C.M.P.), Korea Research Institute of Chemical Technology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea (S.H., C.M.P., Su.Le.); College of Pharmacy, Cha University, Gyeonggi-do, Korea (Se.Le., Y.-G.S.); College of Pharmacy, Seoul National University, Seoul, Korea (Y.-G.S.); College of Pharmacy, Dongguk University, Goyang, Korea (M.K., K.L.)
Jiwon Kong
Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, Korea (D.G.K., S.Li., J.K., S.K.); Drug Information Research Center (S.H., Y.L., Su.Le.) and Center for Convergent Emerging Virus Infection (C.M.P.), Korea Research Institute of Chemical Technology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea (S.H., C.M.P., Su.Le.); College of Pharmacy, Cha University, Gyeonggi-do, Korea (Se.Le., Y.-G.S.); College of Pharmacy, Seoul National University, Seoul, Korea (Y.-G.S.); College of Pharmacy, Dongguk University, Goyang, Korea (M.K., K.L.)
Yuno Lee
Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, Korea (D.G.K., S.Li., J.K., S.K.); Drug Information Research Center (S.H., Y.L., Su.Le.) and Center for Convergent Emerging Virus Infection (C.M.P.), Korea Research Institute of Chemical Technology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea (S.H., C.M.P., Su.Le.); College of Pharmacy, Cha University, Gyeonggi-do, Korea (Se.Le., Y.-G.S.); College of Pharmacy, Seoul National University, Seoul, Korea (Y.-G.S.); College of Pharmacy, Dongguk University, Goyang, Korea (M.K., K.L.)
Chul Min Park
Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, Korea (D.G.K., S.Li., J.K., S.K.); Drug Information Research Center (S.H., Y.L., Su.Le.) and Center for Convergent Emerging Virus Infection (C.M.P.), Korea Research Institute of Chemical Technology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea (S.H., C.M.P., Su.Le.); College of Pharmacy, Cha University, Gyeonggi-do, Korea (Se.Le., Y.-G.S.); College of Pharmacy, Seoul National University, Seoul, Korea (Y.-G.S.); College of Pharmacy, Dongguk University, Goyang, Korea (M.K., K.L.)
Seungbeom Lee
Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, Korea (D.G.K., S.Li., J.K., S.K.); Drug Information Research Center (S.H., Y.L., Su.Le.) and Center for Convergent Emerging Virus Infection (C.M.P.), Korea Research Institute of Chemical Technology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea (S.H., C.M.P., Su.Le.); College of Pharmacy, Cha University, Gyeonggi-do, Korea (Se.Le., Y.-G.S.); College of Pharmacy, Seoul National University, Seoul, Korea (Y.-G.S.); College of Pharmacy, Dongguk University, Goyang, Korea (M.K., K.L.)
Young-Ger Suh
Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, Korea (D.G.K., S.Li., J.K., S.K.); Drug Information Research Center (S.H., Y.L., Su.Le.) and Center for Convergent Emerging Virus Infection (C.M.P.), Korea Research Institute of Chemical Technology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea (S.H., C.M.P., Su.Le.); College of Pharmacy, Cha University, Gyeonggi-do, Korea (Se.Le., Y.-G.S.); College of Pharmacy, Seoul National University, Seoul, Korea (Y.-G.S.); College of Pharmacy, Dongguk University, Goyang, Korea (M.K., K.L.)
Minkyoung Kim
Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, Korea (D.G.K., S.Li., J.K., S.K.); Drug Information Research Center (S.H., Y.L., Su.Le.) and Center for Convergent Emerging Virus Infection (C.M.P.), Korea Research Institute of Chemical Technology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea (S.H., C.M.P., Su.Le.); College of Pharmacy, Cha University, Gyeonggi-do, Korea (Se.Le., Y.-G.S.); College of Pharmacy, Seoul National University, Seoul, Korea (Y.-G.S.); College of Pharmacy, Dongguk University, Goyang, Korea (M.K., K.L.)
Kyeong Lee
Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, Korea (D.G.K., S.Li., J.K., S.K.); Drug Information Research Center (S.H., Y.L., Su.Le.) and Center for Convergent Emerging Virus Infection (C.M.P.), Korea Research Institute of Chemical Technology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea (S.H., C.M.P., Su.Le.); College of Pharmacy, Cha University, Gyeonggi-do, Korea (Se.Le., Y.-G.S.); College of Pharmacy, Seoul National University, Seoul, Korea (Y.-G.S.); College of Pharmacy, Dongguk University, Goyang, Korea (M.K., K.L.)
Sunkyung Lee
Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, Korea (D.G.K., S.Li., J.K., S.K.); Drug Information Research Center (S.H., Y.L., Su.Le.) and Center for Convergent Emerging Virus Infection (C.M.P.), Korea Research Institute of Chemical Technology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea (S.H., C.M.P., Su.Le.); College of Pharmacy, Cha University, Gyeonggi-do, Korea (Se.Le., Y.-G.S.); College of Pharmacy, Seoul National University, Seoul, Korea (Y.-G.S.); College of Pharmacy, Dongguk University, Goyang, Korea (M.K., K.L.)
Sunghoon Kim
Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy & College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, Korea (D.G.K., S.Li., J.K., S.K.); Drug Information Research Center (S.H., Y.L., Su.Le.) and Center for Convergent Emerging Virus Infection (C.M.P.), Korea Research Institute of Chemical Technology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea (S.H., C.M.P., Su.Le.); College of Pharmacy, Cha University, Gyeonggi-do, Korea (Se.Le., Y.-G.S.); College of Pharmacy, Seoul National University, Seoul, Korea (Y.-G.S.); College of Pharmacy, Dongguk University, Goyang, Korea (M.K., K.L.)

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Research ArticleDrug Discovery and Translational Medicine
Kim et al.
Dae Gyu Kim, Srigouri Huddar, Semi Lim, Jiwon Kong, Yuno Lee, Chul Min Park, Seungbeom Lee, Young-Ger Suh, Minkyoung Kim, Kyeong Lee, Sunkyung Lee and Sunghoon Kim
Journal of Pharmacology and Experimental Therapeutics December 1, 2021, 379 (3) 358-371; DOI: https://doi.org/10.1124/jpet.121.000766
Research ArticleDrug Discovery and Translational Medicine
Kim et al.
Dae Gyu Kim, Srigouri Huddar, Semi Lim, Jiwon Kong, Yuno Lee, Chul Min Park, Seungbeom Lee, Young-Ger Suh, Minkyoung Kim, Kyeong Lee, Sunkyung Lee and Sunghoon Kim
Journal of Pharmacology and Experimental Therapeutics December 1, 2021, 379 (3) 358-371; DOI: https://doi.org/10.1124/jpet.121.000766
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