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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

December 01, 2021; Volume 379,Issue 3

Editorial

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    A Farewell to Arms
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 301; DOI: https://doi.org/10.1124/jpet.121.000949

Announcement

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    Announcement - Incoming JPET Editor
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 302; DOI: https://doi.org/10.1124/jpet.121.000924

Minireview

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    5-Aza-4′-thio-2′-deoxycytidine, a New Orally Bioavailable Nontoxic “Best-in-Class”: DNA Methyltransferase 1–Depleting Agent in Clinical Development
    William B. Parker and Jaideep V. Thottassery
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 211-222; DOI: https://doi.org/10.1124/jpet.121.000758
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    Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity
    Douglas R. Miller, Mengfei Bu, Adithya Gopinath, Luis R. Martinez and Habibeh Khoshbouei
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 372-385; DOI: https://doi.org/10.1124/jpet.121.000767

Cardiovascular

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    Cardiac Effects of Novel Histamine H2 Receptor Agonists
    Ulrich Gergs, Maren L. Büxel, Merlin Bresinsky, Uwe Kirchhefer, Charlotte Fehse, Carina Höring, Britt Hofmann, Margaréta Marušáková, Aneta Čináková, Rebecca Schwarz, Steffen Pockes and Joachim Neumann
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 223-234; DOI: https://doi.org/10.1124/jpet.121.000822

Cellular and Molecular

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    Caspase-8 Regulates the Antimyeloma Activity of Bortezomib and Lenalidomide
    Liang Zhou, Xiangao Huang, Ruben Niesvizky, Zhongjian Pu and Guoqiang Xu
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 303-309; DOI: https://doi.org/10.1124/jpet.121.000818

Chemotherapy, Antibiotics, and Gene Therapy

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    Pharmacokinetic and Pharmacodynamic Assessment of Hydroxychloroquine in Breast Cancer
    Kristen M. Van Eaton and Daniel L. Gustafson
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 331-342; DOI: https://doi.org/10.1124/jpet.121.000730

Drug Discovery and Translational Medicine

  • Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis
    Open Access
    Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis
    Robert N. Willette, Parth Mangrolia, Stephen M. Pondell, Christopher Young Woo Lee, Sanghee Yoo, Marc S. Rudoltz, Benjamin R. Cowen and Dean J. Welsch
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 290-300; DOI: https://doi.org/10.1124/jpet.121.000811
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    Therapeutic Effects of Time-Limited Treatment with Brivaracetam on Posttraumatic Epilepsy after Fluid Percussion Injury in the Rat
    Clifford L. Eastman, Jason S. Fender, Pavel Klein and Raimondo D’Ambrosio
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 310-323; DOI: https://doi.org/10.1124/jpet.121.000585
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    A Novel Etomidate Analog EL-0052 Retains Potent Hypnotic Effect and Stable Hemodynamics without Suppressing Adrenocortical Function
    Xiangqing Xu, Yaqin Wei, Yingying Dong, Yinli Qiu, Zhanbiao Mei, Kai Wang, Jingya Xiu, Tao Wang, Lingguo Zeng, Xiaohu Dong, Yi Shen, Wengao Jiang and Qingeng Li
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 324-330; DOI: https://doi.org/10.1124/jpet.121.000691
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    Brain Distribution of Berzosertib: An Ataxia Telangiectasia and Rad3-Related Protein Inhibitor for the Treatment of Glioblastoma
    Surabhi Talele, Wenjuan Zhang, Danielle M. Burgenske, Minjee Kim, Afroz S. Mohammad, Sonja Dragojevic, Shiv K. Gupta, Ranjit S. Bindra, Jann N. Sarkaria and William F. Elmquist
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 343-357; DOI: https://doi.org/10.1124/jpet.121.000845
  • Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2–Depleted Splice Variant of Aminoacyl–Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70
    Open Access
    Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2–Depleted Splice Variant of Aminoacyl–Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70
    Dae Gyu Kim, Srigouri Huddar, Semi Lim, Jiwon Kong, Yuno Lee, Chul Min Park, Seungbeom Lee, Young-Ger Suh, Minkyoung Kim, Kyeong Lee, Sunkyung Lee and Sunghoon Kim
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 358-371; DOI: https://doi.org/10.1124/jpet.121.000766
  • Open Access
    Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5
    Julie V. Selkirk, Kevin C. Dines, Yingzhuo Grace Yan, Nathan Ching, Deepak Dalvie, Shameek Biswas, Andrea Bortolato, Jeffrey M. Schkeryantz, Carlos Lopez, Iliana Ruiz and Richard Hargreaves
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 386-399; DOI: https://doi.org/10.1124/jpet.121.000741
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    Novel Platform for Predicting Drug Effects in Patients with Acromegaly: Translational Exposure-Response Evaluation of Growth Hormone–Inhibitory Effect of Octreotide after Growth Hormone–Releasing Hormone Stimulation
    Hiroyuki Iida, Tatsuya Komagata, Hirotaka Tanaka, Ryusuke Nagasawa, Takuya Nishio, Tomoyuki Shono, Junsaku Kitagawa, Ken-ichi Ogawara, Koji Shinozaki, Akiteru Seki, Mark Bruce and Tomoya Ohno
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 400-408; DOI: https://doi.org/10.1124/jpet.121.000769

Endocrine and Diabetes

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    Selective Inhibition of N-Methyl-d-aspartate Receptors with GluN2B Subunit Protects β Cells against Stress-Induced Apoptotic Cell Death
    Anne Gresch, Héctor Noguera Hurtado, Laura Wörmeyer, Vivien De Luca, Rebekka Wiggers, Guiscard Seebohm, Bernhard Wünsch and Martina Düfer
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 235-244; DOI: https://doi.org/10.1124/jpet.121.000807

Gastrointestinal, Hepatic, Pulmonary, and Renal

  • Physiologic, Metabolic, and Toxicologic Profile of 1,3-Butanediol
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    Physiologic, Metabolic, and Toxicologic Profile of 1,3-Butanediol
    Cameron G. McCarthy, Emily W. Waigi, Gagandeep Singh, Thaddaeus R. Castaneda, Blair Mell, Saroj Chakraborty, Camilla F. Wenceslau and Bina Joe
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 245-252; DOI: https://doi.org/10.1124/jpet.121.000796
  • Open Access
    A Monoclonal Anti–Calcitonin Gene-Related Peptide Antibody Decreases Stress-Induced Colonic Hypersensitivity
    Ehsan Noor-Mohammadi, Casey Owen Ligon, Kimberly Mackenzie, Jennifer Stratton, Sara Shnider and Beverley Greenwood-Van Meerveld
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 270-279; DOI: https://doi.org/10.1124/jpet.121.000731
  • Open Access
    Selective Acetyl-CoA Carboxylase 1 Inhibitor Improves Hepatic Steatosis and Hepatic Fibrosis in a Preclinical Nonalcoholic Steatohepatitis Model
    Yumiko Okano Tamura, Jun Sugama, Shinji Iwasaki, Masako Sasaki, Hironobu Yasuno, Kazunobu Aoyama, Masanori Watanabe, Derek M. Erion and Hiroaki Yashiro
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 280-289; DOI: https://doi.org/10.1124/jpet.121.000786

Metabolism, Transport, and Pharmacogenetics

  • Differential Susceptibilities of Catecholamines to Metabolism by Monoamine Oxidases
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    Differential Susceptibilities of Catecholamines to Metabolism by Monoamine Oxidases
    David S. Goldstein, Genessis Castillo, Patti Sullivan and Yehonatan Sharabi
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 253-259; DOI: https://doi.org/10.1124/jpet.121.000826

Neuropharmacology

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    Glutamate Buffering Capacity and Blood-Brain Barrier Protection of Opioid Receptor Agonists Biphalin and Nociceptin
    Saeideh Nozohouri, Yong Zhang, Thamer H. Albekairi, Bhuvaneshwar Vaidya and Thomas J. Abbruscato
    Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 260-269; DOI: https://doi.org/10.1124/jpet.121.000831
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 379 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 379, Issue 3
1 Dec 2021
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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