Table of Contents

Drug Discovery and Translational Medicine

• 

  Open Access

  Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis

  Robert N. Willette, Parth Mangrolia, Stephen M. Pondell, Christopher Young Woo Lee, Sanghee Yoo, Marc S. Rudoltz, Benjamin R. Cowen and Dean J. Welsch

  Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (3) 290-300; DOI: https://doi.org/10.1124/jpet.121.000811
• You have access

  Therapeutic Effects of Time-Limited Treatment with Brivaracetam on Posttraumatic Epilepsy after Fluid Percussion Injury in the Rat

  Clifford L. Eastman, Jason S. Fender, Pavel Klein and Raimondo D’Ambrosio

  Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 310-323; DOI: https://doi.org/10.1124/jpet.121.000585
• You have access

  A Novel Etomidate Analog EL-0052 Retains Potent Hypnotic Effect and Stable Hemodynamics without Suppressing Adrenocortical Function

  Xiangqing Xu, Yaqin Wei, Yingying Dong, Yinli Qiu, Zhanbiao Mei, Kai Wang, Jingya Xiu, Tao Wang, Lingguo Zeng, Xiaohu Dong, Yi Shen, Wengao Jiang and Qingeng Li

  Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 324-330; DOI: https://doi.org/10.1124/jpet.121.000691
• You have access

  Brain Distribution of Berzosertib: An Ataxia Telangiectasia and Rad3-Related Protein Inhibitor for the Treatment of Glioblastoma

  Surabhi Talele, Wenjuan Zhang, Danielle M. Burgenske, Minjee Kim, Afroz S. Mohammad, Sonja Dragojevic, Shiv K. Gupta, Ranjit S. Bindra, Jann N. Sarkaria and William F. Elmquist

  Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 343-357; DOI: https://doi.org/10.1124/jpet.121.000845
• 

  Open Access

  Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2–Depleted Splice Variant of Aminoacyl–Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70

  Dae Gyu Kim, Srigouri Huddar, Semi Lim, Jiwon Kong, Yuno Lee, Chul Min Park, Seungbeom Lee, Young-Ger Suh, Minkyoung Kim, Kyeong Lee, Sunkyung Lee and Sunghoon Kim

  Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 358-371; DOI: https://doi.org/10.1124/jpet.121.000766
• Open Access

  Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5

  Julie V. Selkirk, Kevin C. Dines, Yingzhuo Grace Yan, Nathan Ching, Deepak Dalvie, Shameek Biswas, Andrea Bortolato, Jeffrey M. Schkeryantz, Carlos Lopez, Iliana Ruiz and Richard Hargreaves

  Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 386-399; DOI: https://doi.org/10.1124/jpet.121.000741
• You have access

  Novel Platform for Predicting Drug Effects in Patients with Acromegaly: Translational Exposure-Response Evaluation of Growth Hormone–Inhibitory Effect of Octreotide after Growth Hormone–Releasing Hormone Stimulation

  Hiroyuki Iida, Tatsuya Komagata, Hirotaka Tanaka, Ryusuke Nagasawa, Takuya Nishio, Tomoyuki Shono, Junsaku Kitagawa, Ken-ichi Ogawara, Koji Shinozaki, Akiteru Seki, Mark Bruce and Tomoya Ohno

  Journal of Pharmacology and Experimental Therapeutics December 2021, 379 (3) 400-408; DOI: https://doi.org/10.1124/jpet.121.000769