Table of Contents

Drug Discovery and Translational Medicine

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  Define Mesenchymal Stem Cell from Its Fate: Biodisposition of Human Mesenchymal Stem Cells in Normal and Concanavalin A–Induced Liver Injury Mice

  Li Han, Chenhui Ma, Huige Peng, Zhitao Wu, Huiming Xu, Jiajun Wu, Ning Zhang, Qinghui Jiang, Chen Ma, Ruimin Huang, Hai Li and Guoyu Pan

  Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 125-133; DOI: https://doi.org/10.1124/jpet.121.000607
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  Identification and Characterization of Two Structurally Related Dipeptides that Enhance Catalytic Efficiency of Neurolysin

  Srinidhi Jayaraman, Joanna Kocot, Shiva Hadi Esfahani, Naomi J. Wangler, Arzu Uyar, Yehia Mechref, Paul C. Trippier, Thomas J. Abbruscato, Alex Dickson, Hideki Aihara, David A. Ostrov and Vardan T. Karamyan

  Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 191-202; DOI: https://doi.org/10.1124/jpet.121.000840
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  Pharmacokinetics and Pharmacodynamic Effects of Nemvaleukin Alfa, a Selective Agonist of the Intermediate-Affinity IL-2 Receptor, in Cynomolgus Monkeys

  Jared E. Lopes, Lei Sun, Heather L. Flick, Erin A. Murphy and Heather C. Losey

  Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 203-210; DOI: https://doi.org/10.1124/jpet.121.000612
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  Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N-Acetylgalactosamine–Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans

  Vivaswath S. Ayyar, Dawei Song, Songmao Zheng, Thomas Carpenter and Donald L. Heald

  Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 134-146; DOI: https://doi.org/10.1124/jpet.121.000805