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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

November 01, 2021; Volume 379,Issue 2

Behavioral Pharmacology

  • You have access
    Influence of Contingent and Noncontingent Drug Histories on the Development of High Levels of MDPV Self-Administration
    Michelle R. Doyle, Agnieszka Sulima, Kenner C. Rice and Gregory T. Collins
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 108-116; DOI: https://doi.org/10.1124/jpet.121.000655

Cardiovascular

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    Streptococcal Exotoxin Streptolysin O Causes Vascular Endothelial Dysfunction Through PKCβ Activation
    Masashi Mukohda, Sho Nakamura, Kosuke Takeya, Akira Matsuda, Takanori Yano, Mihiro Seki, Risuke Mizuno and Hiroshi Ozaki
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 117-124; DOI: https://doi.org/10.1124/jpet.121.000752
  • A Retinoic Acid Receptor <em>β</em><sub>2</sub> Agonist Improves Cardiac Function in a Heart Failure Model
    You have access
    A Retinoic Acid Receptor β2 Agonist Improves Cardiac Function in a Heart Failure Model
    Xiao-Han Tang, Jessica Gambardella, Stanislovas Jankauskas, Xujun Wang, Gaetano Santulli, Lorraine J. Gudas and Roberto Levi
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 182-190; DOI: https://doi.org/10.1124/jpet.121.000806

Chemotherapy, Antibiotics, and Gene Therapy

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    Semimechanistic Modeling of the Effects of Blast Overpressure Exposure on Cefazolin Pharmacokinetics in Mice
    Daniel J. Selig, Geoffrey C. Chin, Alexander G. Bobrov, Jesse P. DeLuca, Derese Getnet, Jeffrey R. Livezey, Joseph B. Long, Venkatasivasai S. Sajja, Brett E. Swierczewski, Stuart D. Tyner and Vlado Antonic
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 175-181; DOI: https://doi.org/10.1124/jpet.121.000797

Drug Discovery and Translational Medicine

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    Define Mesenchymal Stem Cell from Its Fate: Biodisposition of Human Mesenchymal Stem Cells in Normal and Concanavalin A–Induced Liver Injury Mice
    Li Han, Chenhui Ma, Huige Peng, Zhitao Wu, Huiming Xu, Jiajun Wu, Ning Zhang, Qinghui Jiang, Chen Ma, Ruimin Huang, Hai Li and Guoyu Pan
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 125-133; DOI: https://doi.org/10.1124/jpet.121.000607
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    Identification and Characterization of Two Structurally Related Dipeptides that Enhance Catalytic Efficiency of Neurolysin
    Srinidhi Jayaraman, Joanna Kocot, Shiva Hadi Esfahani, Naomi J. Wangler, Arzu Uyar, Yehia Mechref, Paul C. Trippier, Thomas J. Abbruscato, Alex Dickson, Hideki Aihara, David A. Ostrov and Vardan T. Karamyan
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 191-202; DOI: https://doi.org/10.1124/jpet.121.000840
  • Open Access
    Pharmacokinetics and Pharmacodynamic Effects of Nemvaleukin Alfa, a Selective Agonist of the Intermediate-Affinity IL-2 Receptor, in Cynomolgus Monkeys
    Jared E. Lopes, Lei Sun, Heather L. Flick, Erin A. Murphy and Heather C. Losey
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 203-210; DOI: https://doi.org/10.1124/jpet.121.000612
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    Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N-Acetylgalactosamine–Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans
    Vivaswath S. Ayyar, Dawei Song, Songmao Zheng, Thomas Carpenter and Donald L. Heald
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 134-146; DOI: https://doi.org/10.1124/jpet.121.000805

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Puerarin Ameliorates 5-Fluorouracil–Induced Intestinal Mucositis in Mice by Inhibiting JAKs
    Liang Wang, Baohui Song, Yan Hu, Jun Chen, Shuaishuai Zhang, Dapeng Chen and Jingyu Wang
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 147-155; DOI: https://doi.org/10.1124/jpet.121.000677

Inflammation, Immunopharmacology, and Asthma

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    Resolvin Conjugates in Tissue Regeneration 1 Promote Alveolar Fluid Clearance by Activating Alveolar Epithelial Sodium Channels and Na, K-ATPase in Lipopolysaccharide-Induced Acute Lung Injury
    Qian Yang, Hao-ran Xu, Shu-yang Xiang, Chen Zhang, Yang Ye, Chen-xi Shen, Hong-xia Mei, Pu-hong Zhang, Hong-yu Ma, Sheng-xing Zheng, Fang-gao Smith, Sheng-wei Jin and Qian Wang
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 156-165; DOI: https://doi.org/10.1124/jpet.121.000712

Toxicology

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    A Chemoproteomics Approach to Determine the Mechanism of Testicular Toxicity for the Bruton’s Tyrosine Kinase Inhibitor CC-292
    Matt Labenski, Lukas Voortman, Aravind Prasad Medikonda, Philip J. Sherratt and Alan F. Corin
    Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 166-174; DOI: https://doi.org/10.1124/jpet.121.000614
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 379 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 379, Issue 2
1 Nov 2021
  • Table of Contents
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  • Behavioral Pharmacology
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  • Chemotherapy, Antibiotics, and Gene Therapy
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  • Toxicology
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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