Research ArticleMetabolism, Transport, and Pharmacogenetics
Enhancing Target Tissue Levels and Diminishing Plasma Clearance of Ionizing Zwitterionic Antidotes in Organophosphate Exposures
Yan-Jye Shyong, Yadira Sepulveda, Arnold Garcia, Nathan M. Samskey, Zoran Radic, Rakesh K. Sit, K. Barry Sharpless, Jeremiah D. Momper and Palmer Taylor
Journal of Pharmacology and Experimental Therapeutics September 2021, 378 (3) 315-321; DOI: https://doi.org/10.1124/jpet.121.000715
Yan-Jye Shyong
Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, California (Y.-J.S., Y.S., A.G., N.M.S., Z.R., J.D.M., P.T.), and The Scripps Research Institute, Skaggs Institute for Chemical Biology (R.K.S., K.B.S.)
Yadira Sepulveda
Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, California (Y.-J.S., Y.S., A.G., N.M.S., Z.R., J.D.M., P.T.), and The Scripps Research Institute, Skaggs Institute for Chemical Biology (R.K.S., K.B.S.)
Arnold Garcia
Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, California (Y.-J.S., Y.S., A.G., N.M.S., Z.R., J.D.M., P.T.), and The Scripps Research Institute, Skaggs Institute for Chemical Biology (R.K.S., K.B.S.)
Nathan M. Samskey
Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, California (Y.-J.S., Y.S., A.G., N.M.S., Z.R., J.D.M., P.T.), and The Scripps Research Institute, Skaggs Institute for Chemical Biology (R.K.S., K.B.S.)
Zoran Radic
Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, California (Y.-J.S., Y.S., A.G., N.M.S., Z.R., J.D.M., P.T.), and The Scripps Research Institute, Skaggs Institute for Chemical Biology (R.K.S., K.B.S.)
Rakesh K. Sit
Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, California (Y.-J.S., Y.S., A.G., N.M.S., Z.R., J.D.M., P.T.), and The Scripps Research Institute, Skaggs Institute for Chemical Biology (R.K.S., K.B.S.)
K. Barry Sharpless
Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, California (Y.-J.S., Y.S., A.G., N.M.S., Z.R., J.D.M., P.T.), and The Scripps Research Institute, Skaggs Institute for Chemical Biology (R.K.S., K.B.S.)
Jeremiah D. Momper
Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, California (Y.-J.S., Y.S., A.G., N.M.S., Z.R., J.D.M., P.T.), and The Scripps Research Institute, Skaggs Institute for Chemical Biology (R.K.S., K.B.S.)
Palmer Taylor
Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, California (Y.-J.S., Y.S., A.G., N.M.S., Z.R., J.D.M., P.T.), and The Scripps Research Institute, Skaggs Institute for Chemical Biology (R.K.S., K.B.S.)
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Research ArticleMetabolism, Transport, and Pharmacogenetics
Zwitterionic Antidotes to Rescue OP-AChE Inhibition
Yan-Jye Shyong, Yadira Sepulveda, Arnold Garcia, Nathan M. Samskey, Zoran Radic, Rakesh K. Sit, K. Barry Sharpless, Jeremiah D. Momper and Palmer Taylor
Journal of Pharmacology and Experimental Therapeutics September 1, 2021, 378 (3) 315-321; DOI: https://doi.org/10.1124/jpet.121.000715
Research ArticleMetabolism, Transport, and Pharmacogenetics
Zwitterionic Antidotes to Rescue OP-AChE Inhibition
Yan-Jye Shyong, Yadira Sepulveda, Arnold Garcia, Nathan M. Samskey, Zoran Radic, Rakesh K. Sit, K. Barry Sharpless, Jeremiah D. Momper and Palmer Taylor
Journal of Pharmacology and Experimental Therapeutics September 1, 2021, 378 (3) 315-321; DOI: https://doi.org/10.1124/jpet.121.000715
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