Article Figures & Data
Figures
Additional Files
Data Supplement
- Supplemental Figures -
Figure S1. Single systemic administration of vardenafil strongly suppresses retinal function in mice.
Figure S2. Single administration of sildenafil moderately suppresses retinal function in mice.
Figure S3. Single administration of tadalafil shows a mild effect on rod-dominant ERG and an intermediate effect on cone-mediated ERG.
Figure S4. Single administration of a PDE6-selective inhibitor Zaprinast has a negligible effect on retinal function in mice.
Figure S5. Coomassie staining of the hypotonic bovine ROS fraction used in the PDE6-activity assay.
Figure S6. DMSO at a concentration of 0.00026 % in ex vivo ERG perfusion solution does not affect the ERG signal.
Figure S7. Retinal function is not significantly altered in aged heterozygous VCPR155H knock-in mice.
- Supplemental Figures -