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Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal
Open Access

Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters

Michele Leuenberger, Stephanie Häusler, Vera Höhn, Adriana Euler, Bruno Stieger and Martin Lochner
Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 346-357; DOI: https://doi.org/10.1124/jpet.120.000449
Michele Leuenberger
Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland (M.Le., M.Lo.); Department of Clinical Pharmacology and Toxicology, University Hospital Zürich, Zürich, Switzerland (S.H., V.H., A.E., B.S.); and Swiss National Center of Competence in Research, NCCR TransCure, Bern, Switzerland (M.Le., S.H., A.E., B.S., M.Lo.)
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Stephanie Häusler
Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland (M.Le., M.Lo.); Department of Clinical Pharmacology and Toxicology, University Hospital Zürich, Zürich, Switzerland (S.H., V.H., A.E., B.S.); and Swiss National Center of Competence in Research, NCCR TransCure, Bern, Switzerland (M.Le., S.H., A.E., B.S., M.Lo.)
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Vera Höhn
Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland (M.Le., M.Lo.); Department of Clinical Pharmacology and Toxicology, University Hospital Zürich, Zürich, Switzerland (S.H., V.H., A.E., B.S.); and Swiss National Center of Competence in Research, NCCR TransCure, Bern, Switzerland (M.Le., S.H., A.E., B.S., M.Lo.)
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Adriana Euler
Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland (M.Le., M.Lo.); Department of Clinical Pharmacology and Toxicology, University Hospital Zürich, Zürich, Switzerland (S.H., V.H., A.E., B.S.); and Swiss National Center of Competence in Research, NCCR TransCure, Bern, Switzerland (M.Le., S.H., A.E., B.S., M.Lo.)
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Bruno Stieger
Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland (M.Le., M.Lo.); Department of Clinical Pharmacology and Toxicology, University Hospital Zürich, Zürich, Switzerland (S.H., V.H., A.E., B.S.); and Swiss National Center of Competence in Research, NCCR TransCure, Bern, Switzerland (M.Le., S.H., A.E., B.S., M.Lo.)
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Martin Lochner
Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland (M.Le., M.Lo.); Department of Clinical Pharmacology and Toxicology, University Hospital Zürich, Zürich, Switzerland (S.H., V.H., A.E., B.S.); and Swiss National Center of Competence in Research, NCCR TransCure, Bern, Switzerland (M.Le., S.H., A.E., B.S., M.Lo.)
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Article Information

vol. 377 no. 3 346-357
DOI 
https://doi.org/10.1124/jpet.120.000449
PubMed 
33782042

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received December 2, 2020
  • Accepted March 23, 2021
  • Published online May 21, 2021.

Article Versions

  • Earlier version (March 29, 2021 - 08:19).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2021 by The Author(s) This is an open access article distributed under the CC BY Attribution 4.0 International license.

Author Information

  1. Michele Leuenberger1,
  2. Stephanie Häusler1,
  3. Vera Höhn,
  4. Adriana Euler,
  5. Bruno Stieger, and
  6. Martin Lochner
  1. Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland (M.Le., M.Lo.); Department of Clinical Pharmacology and Toxicology, University Hospital Zürich, Zürich, Switzerland (S.H., V.H., A.E., B.S.); and Swiss National Center of Competence in Research, NCCR TransCure, Bern, Switzerland (M.Le., S.H., A.E., B.S., M.Lo.)
  1. Address correspondence to:
    Martin Lochner, Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland. E-mail: martin.lochner{at}ibmm.unibe.ch; or Bruno Stieger, Department of Clinical Pharmacology and Toxicology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland. E-mail: bruno.stieger{at}uzh.ch
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Journal of Pharmacology and Experimental Therapeutics: 377 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 377, Issue 3
1 Jun 2021
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Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal

Canalicular Transporters Studied with Fluorescent Bile Acids

Michele Leuenberger, Stephanie Häusler, Vera Höhn, Adriana Euler, Bruno Stieger and Martin Lochner
Journal of Pharmacology and Experimental Therapeutics June 1, 2021, 377 (3) 346-357; DOI: https://doi.org/10.1124/jpet.120.000449

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Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal

Canalicular Transporters Studied with Fluorescent Bile Acids

Michele Leuenberger, Stephanie Häusler, Vera Höhn, Adriana Euler, Bruno Stieger and Martin Lochner
Journal of Pharmacology and Experimental Therapeutics June 1, 2021, 377 (3) 346-357; DOI: https://doi.org/10.1124/jpet.120.000449
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