Journal of Pharmacology and Experimental Therapeutics: 377 (3)

June 01, 2021; Volume 377,Issue 3

Behavioral Pharmacology

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Novel Antimuscarinic Antidepressant-like Compounds with Reduced Effects on Cognition
Chad R. Johnson, Brian D. Kangas, Emily M. Jutkiewicz, Gail Winger, Jack Bergman, Andrew Coop and James H. Woods

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 336-345; DOI: https://doi.org/10.1124/jpet.120.000337

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Chronic Ca²⁺/Calmodulin-Dependent Protein Kinase II Inhibition Rescues Advanced Heart Failure
Yixi Liu, Qun Shao, Heng-Jie Cheng, Tiankai Li, Xiaowei Zhang, Michael F. Callahan, David Herrington, Dalane Kitzman, David Zhao and Che-Ping Cheng

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 316-325; DOI: https://doi.org/10.1124/jpet.120.000361
Open Access
Therapeutic Assessment of Combination Therapy with a Neprilysin Inhibitor and Angiotensin Type 1 Receptor Antagonist on Angiotensin II–Induced Atherosclerosis, Abdominal Aortic Aneurysms, and Hypertension
Yasir AlSiraj, Sean E. Thatcher, Ching Ling Liang, Heba Ali, Mark Ensor and Lisa A. Cassis

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 326-335; DOI: https://doi.org/10.1124/jpet.121.000525

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circ-Keratin 6c Promotes Malignant Progression and Immune Evasion of Colorectal Cancer through microRNA-485-3p/Programmed Cell Death Receptor Ligand 1 Axis
Zhipeng Jiang, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang and Shuang Chen

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 358-367; DOI: https://doi.org/10.1124/jpet.121.000518
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Poly(ADP-Ribose) Polymerase Inhibitors for Arsenic Trioxide–Resistant Acute Promyelocytic Leukemia: Synergistic In Vitro Antitumor Effects with Hypomethylating Agents or High-Dose Vitamin C
Manuela Giansanti, Antonio De Gabrieli, Salvatore Pasquale Prete, Tiziana Ottone, Maria Domenica Divona, Terry Karimi, Fabio Ciccarone, Maria Teresa Voso, Grazia Graziani and Isabella Faraoni

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 385-397; DOI: https://doi.org/10.1124/jpet.121.000537

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Brain Concentrations of Methylone and Its Metabolites after Systemic Methylone Administration: Relationship to Pharmacodynamic Effects
Nicole Centazzo, Michael R. Chojnacki, Joshua S. Elmore, Raider Rodriguez, Teeshavi Acosta, Masaki Suzuki, Kenner C. Rice, Michael H. Baumann and Marta Concheiro

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 398-406; DOI: https://doi.org/10.1124/jpet.121.000531
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Development of CVN424: A Selective and Novel GPR6 Inverse Agonist Effective in Models of Parkinson Disease
Nicola L. Brice, Hans H. Schiffer, Holger Monenschein, Victoria J. Mulligan, Keith Page, Justin Powell, Xiao Xu, Toni Cheung, J. Russell Burley, Huikai Sun, Louise Dickson, Sean T. Murphy, Nidhi Kaushal, Steve Sheardown, Jason Lawrence, Yun Chen, Darian Bartkowski, Anne Kanta, Joseph Russo, Natalie Hosea, Lee A. Dawson, Stephen H. Hitchcock and Mark B. Carlton

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 407-416; DOI: https://doi.org/10.1124/jpet.120.000438

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Synergistic Pharmacodynamic Effects of Gemcitabine and Fibroblast Growth Factor Receptor Inhibitors on Pancreatic Cancer Cell Cycle Kinetics and Proliferation
Qingxiang Lin, Zhicheng Qian, William J. Jusko, Donald E. Mager, Wen Wee Ma and Robert M. Straubinger

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 370-384; DOI: https://doi.org/10.1124/jpet.120.000412

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Ginsenoside Ro Ameliorates High-Fat Diet–Induced Obesity and Insulin Resistance in Mice via Activation of the G Protein–Coupled Bile Acid Receptor 5 Pathway
Lin-shan Jiang, Wei Li, Tong-xi Zhuang, Jie-jing Yu, Shuai Sun, Zheng-cai Ju, Zheng-tao Wang, Li-li Ding and Li Yang

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 441-451; DOI: https://doi.org/10.1124/jpet.120.000435

Open Access
A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to Evaluate Combination Therapy and Determine In Vivo Synergism
Young Hee Choi, Chao Zhang, Zhenzhen Liu, Mei-Juan Tu, Ai-Xi Yu and Ai-Ming Yu

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 305-315; DOI: https://doi.org/10.1124/jpet.121.000584
Open Access
AM833 Is a Novel Agonist of Calcitonin Family G Protein–Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists
Madeleine M. Fletcher, Peter Keov, Tin T. Truong, Grace Mennen, Caroline A. Hick, Peishen Zhao, Sebastian G.B. Furness, Thomas Kruse, Trine R. Clausen, Denise Wootten and Patrick M. Sexton

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 417-440; DOI: https://doi.org/10.1124/jpet.121.000567

Open Access
Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters
Michele Leuenberger, Stephanie Häusler, Vera Höhn, Adriana Euler, Bruno Stieger and Martin Lochner

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 346-357; DOI: https://doi.org/10.1124/jpet.120.000449

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Comments on “Pharmacological Characterization of Apraglutide a Novel Long-Acting Peptidic Glucagon-Like Peptide-2 Agonist for the Treatment of Short Bowel Syndrome”
Jolanta Skarbaliene, Bjarne Due Larsen, Mark Berner-Hansen and Adam Steensberg

Journal of Pharmacology and Experimental Therapeutics June 2021, 377 (3) 369; DOI: https://doi.org/10.1124/jpet.120.000426