Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2′-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide–Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6

Thomas A. Zanardi; Birgit Korbmacher; Laura Boone; Jeffrey A. Engelhardt; Yanfeng Wang; Sebastien Burel; Bobby Prill; Mariam Aghajan; Shuling Guo; Scott P. Henry

doi:10.1124/jpet.120.000222

Research ArticleToxicology

Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2′-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide–Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6

Thomas A. Zanardi, Birgit Korbmacher, Laura Boone, Jeffrey A. Engelhardt, Yanfeng Wang, Sebastien Burel, Bobby Prill, Mariam Aghajan, Shuling Guo and Scott P. Henry

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 51-63; DOI: https://doi.org/10.1124/jpet.120.000222

Thomas A. Zanardi