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Research ArticleBehavioral Pharmacology

Activation of Neuronal Voltage-Gated Potassium Kv7/KCNQ/M-Current by a Novel Channel Opener SCR2682 for Alleviation of Chronic Pain

Jing Wang, Yani Liu, Fang Hu, Jiuyong Yang, Xiaoyu Guo, Xingming Hou, Chuanxia Ju and KeWei Wang
Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 20-28; DOI: https://doi.org/10.1124/jpet.120.000357
Jing Wang
Department of Pharmacology, School of Pharmacy at Qingdao University Medical College, Qingdao, China (J.W., Y.L., F.H., J.Y., X.G., X.H., C.J., K.W.); Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, China (Y.L., K.W.); and Institute of Innovative Drugs, Qingdao University, Qingdao, China (Y.L., K.W.)
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Yani Liu
Department of Pharmacology, School of Pharmacy at Qingdao University Medical College, Qingdao, China (J.W., Y.L., F.H., J.Y., X.G., X.H., C.J., K.W.); Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, China (Y.L., K.W.); and Institute of Innovative Drugs, Qingdao University, Qingdao, China (Y.L., K.W.)
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Fang Hu
Department of Pharmacology, School of Pharmacy at Qingdao University Medical College, Qingdao, China (J.W., Y.L., F.H., J.Y., X.G., X.H., C.J., K.W.); Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, China (Y.L., K.W.); and Institute of Innovative Drugs, Qingdao University, Qingdao, China (Y.L., K.W.)
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Jiuyong Yang
Department of Pharmacology, School of Pharmacy at Qingdao University Medical College, Qingdao, China (J.W., Y.L., F.H., J.Y., X.G., X.H., C.J., K.W.); Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, China (Y.L., K.W.); and Institute of Innovative Drugs, Qingdao University, Qingdao, China (Y.L., K.W.)
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Xiaoyu Guo
Department of Pharmacology, School of Pharmacy at Qingdao University Medical College, Qingdao, China (J.W., Y.L., F.H., J.Y., X.G., X.H., C.J., K.W.); Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, China (Y.L., K.W.); and Institute of Innovative Drugs, Qingdao University, Qingdao, China (Y.L., K.W.)
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Xingming Hou
Department of Pharmacology, School of Pharmacy at Qingdao University Medical College, Qingdao, China (J.W., Y.L., F.H., J.Y., X.G., X.H., C.J., K.W.); Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, China (Y.L., K.W.); and Institute of Innovative Drugs, Qingdao University, Qingdao, China (Y.L., K.W.)
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Chuanxia Ju
Department of Pharmacology, School of Pharmacy at Qingdao University Medical College, Qingdao, China (J.W., Y.L., F.H., J.Y., X.G., X.H., C.J., K.W.); Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, China (Y.L., K.W.); and Institute of Innovative Drugs, Qingdao University, Qingdao, China (Y.L., K.W.)
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KeWei Wang
Department of Pharmacology, School of Pharmacy at Qingdao University Medical College, Qingdao, China (J.W., Y.L., F.H., J.Y., X.G., X.H., C.J., K.W.); Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, China (Y.L., K.W.); and Institute of Innovative Drugs, Qingdao University, Qingdao, China (Y.L., K.W.)
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Abstract

Treatment of chronic pain remains an unmet medical need. The neuronal voltage-gated potassium Kv7/KCNQ/M channel has been implicated as a therapeutic target for chronic pain. However, whether pharmacological activation of the Kv7 channel can alleviate pain remains elusive. In this study, we show that selective activation of native M-currents by a novel channel opener SCR2682 reduces repetitive firings of dorsal root ganglia (DRG) sensory neurons. Intraperitoneal administration of SCR2682 relieves mechanical allodynia and thermal hyperalgesia in rat models of pain induced by complete Freund’s adjuvant (CFA) or spared nerve injury (SNI) in a dose-dependent manner without affecting locomotor activity. The antinociceptive efficacy of SCR2682 can be reversed by the channel-specific blocker XE991. Furthermore, SCR2682 increases Kv7.2/KCNQ2 mRNA and protein expression in DRG neurons from rats in the SNI model of neuropathic pain. Taken together, pharmacological activation of neuronal Kv7 channels by opener SCR2682 can alleviate pain in rats, thus possessing therapeutic potential for chronic pain or hyperexcitability-related neurologic disorders.

SIGNIFICANCE STATEMENT A novel voltage-gated potassium Kv7 channel opener SCR2682 inhibits action potential firings in dorsal root ganglia sensory neurons and exhibits efficacy in antinociception, thus possessing a developmental potential for treatment of chronic pain or epilepsy.

Footnotes

    • Received September 29, 2020.
    • Accepted January 6, 2021.
  • ↵1 J.W. and Y.L. contributed equally.

  • This project was supported by grants awarded to K.W. and C.J. from National Natural Sciences Foundation of China [81573410, 81973299], the Ministry of Science and Technology of China [2018ZX09711001-004-006], Science and Technology Program of Guangdong [2018B030334001], the Shandong Province Higher Educational Science and Technology Program [J17KA236], the Science and Technology Program of Qingdao [19-6-1-31-nsh], and Shandong Provincial Natural Science Foundation [ZR2020MH155].

  • No author has an actual or perceived conflict of interest with the contents of this article.

  • https://doi.org/10.1124/jpet.120.000357.

  • Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 377 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 377, Issue 1
1 Apr 2021
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Research ArticleBehavioral Pharmacology

Kv7 Opener SCR2682 Alleviates Pain

Jing Wang, Yani Liu, Fang Hu, Jiuyong Yang, Xiaoyu Guo, Xingming Hou, Chuanxia Ju and KeWei Wang
Journal of Pharmacology and Experimental Therapeutics April 1, 2021, 377 (1) 20-28; DOI: https://doi.org/10.1124/jpet.120.000357

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Research ArticleBehavioral Pharmacology

Kv7 Opener SCR2682 Alleviates Pain

Jing Wang, Yani Liu, Fang Hu, Jiuyong Yang, Xiaoyu Guo, Xingming Hou, Chuanxia Ju and KeWei Wang
Journal of Pharmacology and Experimental Therapeutics April 1, 2021, 377 (1) 20-28; DOI: https://doi.org/10.1124/jpet.120.000357
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