Journal of Pharmacology and Experimental Therapeutics: 377 (1)

April 01, 2021; Volume 377,Issue 1

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Targeting the Protective Arm of the Renin-Angiotensin System: Focused on Angiotensin-(1–7)
Sana Khajehpour and Ali Aghazadeh-Habashi

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 64-74; DOI: https://doi.org/10.1124/jpet.120.000397

Behavioral Pharmacology

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Activation of Neuronal Voltage-Gated Potassium Kv7/KCNQ/M-Current by a Novel Channel Opener SCR2682 for Alleviation of Chronic Pain
Jing Wang, Yani Liu, Fang Hu, Jiuyong Yang, Xiaoyu Guo, Xingming Hou, Chuanxia Ju and KeWei Wang

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 20-28; DOI: https://doi.org/10.1124/jpet.120.000357
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Methocinnamox Reverses and Prevents Fentanyl-Induced Ventilatory Depression in Rats
Victor M. Jimenez, Gabriel Castaneda and Charles P. France

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 29-38; DOI: https://doi.org/10.1124/jpet.120.000387
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Enhancement of Opioid Antinociception by Nicotinic Ligands
Fernando B. de Moura and Jack Bergman

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 100-107; DOI: https://doi.org/10.1124/jpet.120.000423
Open Access
Rapid Throughput Concentration-Response Analysis of Human Taste Discrimination
R. Kyle Palmer, Mariah M. Stewart and John Talley

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 133-145; DOI: https://doi.org/10.1124/jpet.120.000373

Cardiovascular

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Acetate, a Short-Chain Fatty Acid, Acutely Lowers Heart Rate and Cardiac Contractility Along with Blood Pressure
Brian G. Poll, Jiaojiao Xu, Seungho Jun, Jason Sanchez, Nathan A. Zaidman, Xiaojun He, Laeben Lester, Dan E. Berkowitz, Nazareno Paolocci, Wei Dong Gao and Jennifer L. Pluznick

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 39-50; DOI: https://doi.org/10.1124/jpet.120.000187

Cellular and Molecular

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Increased Interleukin-10 Expression by the Inhibition of Ca²⁺-Activated K⁺ Channel K_Ca3.1 in CD4⁺CD25⁺ Regulatory T Cells in the Recovery Phase in an Inflammatory Bowel Disease Mouse Model
Susumu Ohya, Miki Matsui, Junko Kajikuri, Kyoko Endo and Hiroaki Kito

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 75-85; DOI: https://doi.org/10.1124/jpet.120.000395
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A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart
Himangshu S. Bose, Randy M. Whittal, Brendan Marshall, Maheshinie Rajapaksha, Ning Ping Wang, Madhuchanda Bose, Elizabeth W. Perry, Zhi-Qing Zhao and Walter L. Miller

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 108-120; DOI: https://doi.org/10.1124/jpet.120.000365
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Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish
Leilei Zhang, Seok-Hyung Kim, Ki-Hoon Park, Zhi-wei Ye, Jie Zhang, Danyelle M. Townsend and Kenneth D. Tew

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 121-132; DOI: https://doi.org/10.1124/jpet.120.000417

Drug Discovery and Translational Medicine

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Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity
Dianne K. Bryce, Chris M. Ware, Janice D. Woodhouse, Paul J. Ciaccio, J. Michael Ellis, Laxminarayan G. Hegde, Sabu Kuruvilla, Matthew L. Maddess, Carrie G. Markgraf, Karin M. Otte, Frederique M. Poulet, Lauren M. Timmins, Matthew E. Kennedy and Matthew J. Fell

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 11-19; DOI: https://doi.org/10.1124/jpet.120.000217
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A Network Pharmacology–Based Analysis of the Protective Mechanism of Miao Medicine Xuemaitong Capsule Against Secondary Brain Damage in the Ischemic Area Surrounding Intracerebral Hemorrhage
Bo Zhang, Zhengyan Zeng and Haijun Wu

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 86-99; DOI: https://doi.org/10.1124/jpet.120.000083
Open Access
Apigenin Ameliorates Insulin Resistance and Lipid Accumulation by Endoplasmic Reticulum Stress and SREBP-1c/SREBP-2 Pathway in Palmitate-Induced HepG2 Cells and High-Fat Diet–Fed Mice
Liling Wu, Tingdong Guo, Ranxi Deng, Lusheng Liu and Yongxiong Yu

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 146-156; DOI: https://doi.org/10.1124/jpet.120.000162
Open Access
Understanding Exposure-Receptor Occupancy Relationships for Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators across a Range of Preclinical and Clinical Studies
Kirstie A. Bennett, Eugenia Sergeev, Cliona P. MacSweeney, Geor Bakker and Anne E. Cooper

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 157-168; DOI: https://doi.org/10.1124/jpet.120.000371

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Knockout of γ-Adducin Promotes N^G-Nitro-L-Arginine-Methyl-Ester–Induced Hypertensive Renal Injury
Letao Fan, Wenjun Gao, Yedan Liu, Joshua R. Jefferson, Fan Fan and Richard J. Roman

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 189-198; DOI: https://doi.org/10.1124/jpet.120.000408

Metabolism, Transport, and Pharmacogenetics

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Organic Anion–Transporting Polypeptide 1B1/1B3–Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro–In Vivo Evaluation in Cynomolgus Monkey
Heather Eng, Yi-an Bi, Mark A. West, Sangwoo Ryu, Emi Yamaguchi, Rachel E. Kosa, David A. Tess, David A. Griffith, John Litchfield, Amit S. Kalgutkar and Manthena V. S. Varma

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 169-180; DOI: https://doi.org/10.1124/jpet.120.000457

Neuropharmacology

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Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism
Li-Ping Liang, Ruth Fulton, Erica L. Bradshaw-Pierce, Jennifer Pearson-Smith, Brian J. Day and Manisha Patel

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 1-10; DOI: https://doi.org/10.1124/jpet.120.000229
Open Access
Oxysterols Modulate the Acute Effects of Ethanol on Hippocampal N-Methyl-d-Aspartate Receptors, Long-Term Potentiation, and Learning
Yukitoshi Izumi, Steven J. Mennerick, James J. Doherty and Charles F. Zorumski

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 181-188; DOI: https://doi.org/10.1124/jpet.120.000376

Toxicology

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Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2′-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide–Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6
Thomas A. Zanardi, Birgit Korbmacher, Laura Boone, Jeffrey A. Engelhardt, Yanfeng Wang, Sebastien Burel, Bobby Prill, Mariam Aghajan, Shuling Guo and Scott P. Henry

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 51-63; DOI: https://doi.org/10.1124/jpet.120.000222

Errata

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Correction to “Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish”
Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 199; DOI: https://doi.org/10.1124/jpet.120.000417err
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Correction to “A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart”
Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 200; DOI: https://doi.org/10.1124/jpet.120.000365err

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Table of Contents

Minireview

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Metabolism, Transport, and Pharmacogenetics

Neuropharmacology

Toxicology

Errata

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