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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

April 01, 2021; Volume 377,Issue 1

Minireview

  • Targeting the Protective Arm of the Renin-Angiotensin System: Focused on Angiotensin-(1–7)
    You have access
    Targeting the Protective Arm of the Renin-Angiotensin System: Focused on Angiotensin-(1–7)
    Sana Khajehpour and Ali Aghazadeh-Habashi
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 64-74; DOI: https://doi.org/10.1124/jpet.120.000397

Behavioral Pharmacology

  • You have access
    Activation of Neuronal Voltage-Gated Potassium Kv7/KCNQ/M-Current by a Novel Channel Opener SCR2682 for Alleviation of Chronic Pain
    Jing Wang, Yani Liu, Fang Hu, Jiuyong Yang, Xiaoyu Guo, Xingming Hou, Chuanxia Ju and KeWei Wang
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 20-28; DOI: https://doi.org/10.1124/jpet.120.000357
  • You have access
    Methocinnamox Reverses and Prevents Fentanyl-Induced Ventilatory Depression in Rats
    Victor M. Jimenez, Gabriel Castaneda and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 29-38; DOI: https://doi.org/10.1124/jpet.120.000387
  • You have access
    Enhancement of Opioid Antinociception by Nicotinic Ligands
    Fernando B. de Moura and Jack Bergman
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 100-107; DOI: https://doi.org/10.1124/jpet.120.000423
  • Open Access
    Rapid Throughput Concentration-Response Analysis of Human Taste Discrimination
    R. Kyle Palmer, Mariah M. Stewart and John Talley
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 133-145; DOI: https://doi.org/10.1124/jpet.120.000373

Cardiovascular

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    Acetate, a Short-Chain Fatty Acid, Acutely Lowers Heart Rate and Cardiac Contractility Along with Blood Pressure
    Brian G. Poll, Jiaojiao Xu, Seungho Jun, Jason Sanchez, Nathan A. Zaidman, Xiaojun He, Laeben Lester, Dan E. Berkowitz, Nazareno Paolocci, Wei Dong Gao and Jennifer L. Pluznick
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 39-50; DOI: https://doi.org/10.1124/jpet.120.000187

Cellular and Molecular

  • Increased Interleukin-10 Expression by the Inhibition of Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel K<sub>Ca</sub>3.1 in CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T Cells in the Recovery Phase in an Inflammatory Bowel Disease Mouse Model
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    Increased Interleukin-10 Expression by the Inhibition of Ca2+-Activated K+ Channel KCa3.1 in CD4+CD25+ Regulatory T Cells in the Recovery Phase in an Inflammatory Bowel Disease Mouse Model
    Susumu Ohya, Miki Matsui, Junko Kajikuri, Kyoko Endo and Hiroaki Kito
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 75-85; DOI: https://doi.org/10.1124/jpet.120.000395
  • You have access
    A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart
    Himangshu S. Bose, Randy M. Whittal, Brendan Marshall, Maheshinie Rajapaksha, Ning Ping Wang, Madhuchanda Bose, Elizabeth W. Perry, Zhi-Qing Zhao and Walter L. Miller
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 108-120; DOI: https://doi.org/10.1124/jpet.120.000365
  • You have access
    Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish
    Leilei Zhang, Seok-Hyung Kim, Ki-Hoon Park, Zhi-wei Ye, Jie Zhang, Danyelle M. Townsend and Kenneth D. Tew
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 121-132; DOI: https://doi.org/10.1124/jpet.120.000417

Drug Discovery and Translational Medicine

  • You have access
    Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity
    Dianne K. Bryce, Chris M. Ware, Janice D. Woodhouse, Paul J. Ciaccio, J. Michael Ellis, Laxminarayan G. Hegde, Sabu Kuruvilla, Matthew L. Maddess, Carrie G. Markgraf, Karin M. Otte, Frederique M. Poulet, Lauren M. Timmins, Matthew E. Kennedy and Matthew J. Fell
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 11-19; DOI: https://doi.org/10.1124/jpet.120.000217
  • You have access
    A Network Pharmacology–Based Analysis of the Protective Mechanism of Miao Medicine Xuemaitong Capsule Against Secondary Brain Damage in the Ischemic Area Surrounding Intracerebral Hemorrhage
    Bo Zhang, Zhengyan Zeng and Haijun Wu
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 86-99; DOI: https://doi.org/10.1124/jpet.120.000083
  • Open Access
    Apigenin Ameliorates Insulin Resistance and Lipid Accumulation by Endoplasmic Reticulum Stress and SREBP-1c/SREBP-2 Pathway in Palmitate-Induced HepG2 Cells and High-Fat Diet–Fed Mice
    Liling Wu, Tingdong Guo, Ranxi Deng, Lusheng Liu and Yongxiong Yu
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 146-156; DOI: https://doi.org/10.1124/jpet.120.000162
  • Open Access
    Understanding Exposure-Receptor Occupancy Relationships for Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators across a Range of Preclinical and Clinical Studies
    Kirstie A. Bennett, Eugenia Sergeev, Cliona P. MacSweeney, Geor Bakker and Anne E. Cooper
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 157-168; DOI: https://doi.org/10.1124/jpet.120.000371

Gastrointestinal, Hepatic, Pulmonary, and Renal

  • You have access
    Knockout of γ-Adducin Promotes NG-Nitro-L-Arginine-Methyl-Ester–Induced Hypertensive Renal Injury
    Letao Fan, Wenjun Gao, Yedan Liu, Joshua R. Jefferson, Fan Fan and Richard J. Roman
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 189-198; DOI: https://doi.org/10.1124/jpet.120.000408

Metabolism, Transport, and Pharmacogenetics

  • You have access
    Organic Anion–Transporting Polypeptide 1B1/1B3–Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro–In Vivo Evaluation in Cynomolgus Monkey
    Heather Eng, Yi-an Bi, Mark A. West, Sangwoo Ryu, Emi Yamaguchi, Rachel E. Kosa, David A. Tess, David A. Griffith, John Litchfield, Amit S. Kalgutkar and Manthena V. S. Varma
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 169-180; DOI: https://doi.org/10.1124/jpet.120.000457

Neuropharmacology

  • You have access
    Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism
    Li-Ping Liang, Ruth Fulton, Erica L. Bradshaw-Pierce, Jennifer Pearson-Smith, Brian J. Day and Manisha Patel
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 1-10; DOI: https://doi.org/10.1124/jpet.120.000229
  • Open Access
    Oxysterols Modulate the Acute Effects of Ethanol on Hippocampal N-Methyl-d-Aspartate Receptors, Long-Term Potentiation, and Learning
    Yukitoshi Izumi, Steven J. Mennerick, James J. Doherty and Charles F. Zorumski
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 181-188; DOI: https://doi.org/10.1124/jpet.120.000376

Toxicology

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    Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2′-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide–Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6
    Thomas A. Zanardi, Birgit Korbmacher, Laura Boone, Jeffrey A. Engelhardt, Yanfeng Wang, Sebastien Burel, Bobby Prill, Mariam Aghajan, Shuling Guo and Scott P. Henry
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 51-63; DOI: https://doi.org/10.1124/jpet.120.000222

Errata

  • You have access
    Correction to “Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish”
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 199; DOI: https://doi.org/10.1124/jpet.120.000417err
  • You have access
    Correction to “A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart”
    Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 200; DOI: https://doi.org/10.1124/jpet.120.000365err
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 377 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 377, Issue 1
1 Apr 2021
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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Jump to

  • Minireview
  • Behavioral Pharmacology
  • Cardiovascular
  • Cellular and Molecular
  • Drug Discovery and Translational Medicine
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Metabolism, Transport, and Pharmacogenetics
  • Neuropharmacology
  • Toxicology
  • Errata
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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