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Research ArticleDrug Discovery and Translational Medicine

Identification of a Human Whole Blood–Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo

Xiaoping Xu, Navin Goyal, Melissa H. Costell, Theresa Roethke, Christian H. James, Kevin S. Thorneloe, Jaclyn Patterson, Patrick Stoy, Krista Goodman, Dennis L. Sprecher and David J. Behm
Journal of Pharmacology and Experimental Therapeutics March 2021, 376 (3) 436-443; DOI: https://doi.org/10.1124/jpet.120.000307
Xiaoping Xu
GlaxoSmithKline, Collegeville, Pennsylvania
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Navin Goyal
GlaxoSmithKline, Collegeville, Pennsylvania
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Melissa H. Costell
GlaxoSmithKline, Collegeville, Pennsylvania
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Theresa Roethke
GlaxoSmithKline, Collegeville, Pennsylvania
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Christian H. James
GlaxoSmithKline, Collegeville, Pennsylvania
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Kevin S. Thorneloe
GlaxoSmithKline, Collegeville, Pennsylvania
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Jaclyn Patterson
GlaxoSmithKline, Collegeville, Pennsylvania
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Patrick Stoy
GlaxoSmithKline, Collegeville, Pennsylvania
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Krista Goodman
GlaxoSmithKline, Collegeville, Pennsylvania
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Dennis L. Sprecher
GlaxoSmithKline, Collegeville, Pennsylvania
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David J. Behm
GlaxoSmithKline, Collegeville, Pennsylvania
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Journal of Pharmacology and Experimental Therapeutics: 376 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 376, Issue 3
1 Mar 2021
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Research ArticleDrug Discovery and Translational Medicine

Cellular Impedance Assay to Predict Human TRPV4 Inhibition

Xiaoping Xu, Navin Goyal, Melissa H. Costell, Theresa Roethke, Christian H. James, Kevin S. Thorneloe, Jaclyn Patterson, Patrick Stoy, Krista Goodman, Dennis L. Sprecher and David J. Behm
Journal of Pharmacology and Experimental Therapeutics March 1, 2021, 376 (3) 436-443; DOI: https://doi.org/10.1124/jpet.120.000307

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Research ArticleDrug Discovery and Translational Medicine

Cellular Impedance Assay to Predict Human TRPV4 Inhibition

Xiaoping Xu, Navin Goyal, Melissa H. Costell, Theresa Roethke, Christian H. James, Kevin S. Thorneloe, Jaclyn Patterson, Patrick Stoy, Krista Goodman, Dennis L. Sprecher and David J. Behm
Journal of Pharmacology and Experimental Therapeutics March 1, 2021, 376 (3) 436-443; DOI: https://doi.org/10.1124/jpet.120.000307
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