Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity

Jaromir Vlach; Andrew T. Bender; Melinda Przetak; Albertina Pereira; Aditee Deshpande; Theresa L. Johnson; Sonja Reissig; Evgeni Tzvetkov; Djordje Musil; Noune Tahmassian Morse; Philipp Haselmayer; Simone C. Zimmerli; Shinji L. Okitsu; Robert L. Walsky; Brian Sherer

doi:10.1124/jpet.120.000275

Research ArticleDrug Discovery and Translational Medicine

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Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity

Jaromir Vlach, Andrew T. Bender, Melinda Przetak, Albertina Pereira, Aditee Deshpande, Theresa L. Johnson, Sonja Reissig, Evgeni Tzvetkov, Djordje Musil, Noune Tahmassian Morse, Philipp Haselmayer, Simone C. Zimmerli, Shinji L. Okitsu, Robert L. Walsky and Brian Sherer

Journal of Pharmacology and Experimental Therapeutics March 2021, 376 (3) 397-409; DOI: https://doi.org/10.1124/jpet.120.000275

Jaromir Vlach

EMD Serono (a business of Merck KGaA, Darmstadt, Germany), Billerica, Massachusetts (J.V., A.T.B., M.P., A.P., A.D., T.J., E.T., N.T.M., S.F.Z., S.L.O., R.W., B.S.) and Merck KGaA, Darmstadt, Germany (S.R., D.M., P.H.)

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Andrew T. Bender

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Melinda Przetak

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Albertina Pereira

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Aditee Deshpande

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Theresa L. Johnson

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Sonja Reissig

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Evgeni Tzvetkov

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Djordje Musil

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Noune Tahmassian Morse

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Philipp Haselmayer

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Simone C. Zimmerli

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Shinji L. Okitsu

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Robert L. Walsky

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Brian Sherer

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Journal of Pharmacology and Experimental Therapeutics

Vol. 376, Issue 3

1 Mar 2021

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Research ArticleDrug Discovery and Translational Medicine