Department of Medicine, Center for Integrated Research and Unit of Drug Sciences (G.M., E.S.), and Clinical Pharmacology (P.M.), Campus Bio-Medico University Hospital, Rome, Italy; Department of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Rome, Italy (M.C.); and Biostatistics and Data Management Unit, Mediservice S.r.l., Agrate Brianza, Monza, Italy (G.R.)

Department of Medicine, Center for Integrated Research and Unit of Drug Sciences (G.M., E.S.), and Clinical Pharmacology (P.M.), Campus Bio-Medico University Hospital, Rome, Italy; Department of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Rome, Italy (M.C.); and Biostatistics and Data Management Unit, Mediservice S.r.l., Agrate Brianza, Monza, Italy (G.R.)

Department of Medicine, Center for Integrated Research and Unit of Drug Sciences (G.M., E.S.), and Clinical Pharmacology (P.M.), Campus Bio-Medico University Hospital, Rome, Italy; Department of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Rome, Italy (M.C.); and Biostatistics and Data Management Unit, Mediservice S.r.l., Agrate Brianza, Monza, Italy (G.R.)

Department of Medicine, Center for Integrated Research and Unit of Drug Sciences (G.M., E.S.), and Clinical Pharmacology (P.M.), Campus Bio-Medico University Hospital, Rome, Italy; Department of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Rome, Italy (M.C.); and Biostatistics and Data Management Unit, Mediservice S.r.l., Agrate Brianza, Monza, Italy (G.R.)

Department of Medicine, Center for Integrated Research and Unit of Drug Sciences (G.M., E.S.), and Clinical Pharmacology (P.M.), Campus Bio-Medico University Hospital, Rome, Italy; Department of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Rome, Italy (M.C.); and Biostatistics and Data Management Unit, Mediservice S.r.l., Agrate Brianza, Monza, Italy (G.R.)