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Research ArticleMinireview
Open Access

The Pharmacological Case for Cannabigerol

Rahul Nachnani, Wesley M. Raup-Konsavage and Kent E. Vrana
Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 204-212; DOI: https://doi.org/10.1124/jpet.120.000340
Rahul Nachnani
Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania
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Wesley M. Raup-Konsavage
Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania
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Kent E. Vrana
Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania
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Abstract

Medical cannabis and individual cannabinoids, such as Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), are receiving growing attention in both the media and the scientific literature. The Cannabis plant, however, produces over 100 different cannabinoids, and cannabigerol (CBG) serves as the precursor molecule for the most abundant phytocannabinoids. CBG exhibits affinity and activity characteristics between Δ9-THC and CBD at the cannabinoid receptors but appears to be unique in its interactions with α-2 adrenoceptors and 5-hydroxytryptamine (5-HT1A). Studies indicate that CBG may have therapeutic potential in treating neurologic disorders (e.g., Huntington disease, Parkinson disease, and multiple sclerosis) and inflammatory bowel disease, as well as having antibacterial activity. There is growing interest in the commercial use of this unregulated phytocannabinoid. This review focuses on the unique pharmacology of CBG, our current knowledge of its possible therapeutic utility, and its potential toxicological hazards.

SIGNIFICANCE STATEMENT Cannabigerol is currently being marketed as a dietary supplement and, as with cannabidiol (CBD) before, many claims are being made about its benefits. Unlike CBD, however, little research has been performed on this unregulated molecule, and much of what is known warrants further investigation to identify potential areas of therapeutic uses and hazards.

Footnotes

    • Received September 15, 2020.
    • Accepted November 4, 2020.
  • This work was supported by a sponsored research agreement from Pennsylvania Options for Wellness (to K.E.V.).

  • No author has an actual or perceived conflict of interest with the contents of this article.

  • https://doi.org/10.1124/jpet.120.000340.

  • Copyright © 2021 by The Author(s)

This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

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Journal of Pharmacology and Experimental Therapeutics: 376 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 376, Issue 2
1 Feb 2021
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Research ArticleMinireview

Potential Clinical Uses of CBG

Rahul Nachnani, Wesley M. Raup-Konsavage and Kent E. Vrana
Journal of Pharmacology and Experimental Therapeutics February 1, 2021, 376 (2) 204-212; DOI: https://doi.org/10.1124/jpet.120.000340

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Research ArticleMinireview

Potential Clinical Uses of CBG

Rahul Nachnani, Wesley M. Raup-Konsavage and Kent E. Vrana
Journal of Pharmacology and Experimental Therapeutics February 1, 2021, 376 (2) 204-212; DOI: https://doi.org/10.1124/jpet.120.000340
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