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Research ArticleInflammation, Immunopharmacology, and Asthma

Prostanoid Receptors of the EP4-Subtype Mediate Gene Expression Changes in Human Airway Epithelial Cells with Potential Anti-Inflammatory Activity

Radhika Joshi, Omar Hamed, Dong Yan, Aubrey N. Michi, Mahmoud M. Mostafa, Shahina Wiehler, Robert Newton and Mark A. Giembycz
Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 161-180; DOI: https://doi.org/10.1124/jpet.120.000196
Radhika Joshi
Department of Physiology and Pharmacology, Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Omar Hamed
Department of Physiology and Pharmacology, Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Dong Yan
Department of Physiology and Pharmacology, Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Aubrey N. Michi
Department of Physiology and Pharmacology, Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Mahmoud M. Mostafa
Department of Physiology and Pharmacology, Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Shahina Wiehler
Department of Physiology and Pharmacology, Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Robert Newton
Department of Physiology and Pharmacology, Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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  • ORCID record for Robert Newton
Mark A. Giembycz
Department of Physiology and Pharmacology, Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Article Information

vol. 376 no. 2 161-180
DOI 
https://doi.org/10.1124/jpet.120.000196
PubMed 
33158942

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received July 4, 2020
  • Accepted November 3, 2020
  • Published online January 19, 2021.

Article Versions

  • Earlier version (November 6, 2020 - 11:09).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Radhika Joshi1,
  2. Omar Hamed1,
  3. Dong Yan1,2,
  4. Aubrey N. Michi,
  5. Mahmoud M. Mostafa,
  6. Shahina Wiehler,
  7. Robert Newton, and
  8. Mark A. Giembycz
  1. Department of Physiology and Pharmacology, Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
  1. Address correspondence to:
    Dr. Mark A. Giembycz, Department of Physiology and Pharmacology, Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, 3820 Hospital Dr. N.W., Calgary, AB, Canada T2N 4N1. E-mail: giembycz{at}ucalgary.ca
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Journal of Pharmacology and Experimental Therapeutics: 376 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 376, Issue 2
1 Feb 2021
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Research ArticleInflammation, Immunopharmacology, and Asthma

Genomic Effects of an EP4-Receptor Agonist in Human Airway Epithelia

Radhika Joshi, Omar Hamed, Dong Yan, Aubrey N. Michi, Mahmoud M. Mostafa, Shahina Wiehler, Robert Newton and Mark A. Giembycz
Journal of Pharmacology and Experimental Therapeutics February 1, 2021, 376 (2) 161-180; DOI: https://doi.org/10.1124/jpet.120.000196

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Research ArticleInflammation, Immunopharmacology, and Asthma

Genomic Effects of an EP4-Receptor Agonist in Human Airway Epithelia

Radhika Joshi, Omar Hamed, Dong Yan, Aubrey N. Michi, Mahmoud M. Mostafa, Shahina Wiehler, Robert Newton and Mark A. Giembycz
Journal of Pharmacology and Experimental Therapeutics February 1, 2021, 376 (2) 161-180; DOI: https://doi.org/10.1124/jpet.120.000196
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