Journal of Pharmacology and Experimental Therapeutics: 376 (2)

February 01, 2021; Volume 376,Issue 2

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The Pharmacological Case for Cannabigerol
Rahul Nachnani, Wesley M. Raup-Konsavage and Kent E. Vrana

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 204-212; DOI: https://doi.org/10.1124/jpet.120.000340

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Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury
Young Lee, Purvi Mehrotra, David Basile, Mahbub Ullah, Arshnoor Singh, Nicholas Skill, Subhi Talal Younes, Jennifer Sasser, Anantha Shekhar and Jaipal Singh

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 181-189; DOI: https://doi.org/10.1124/jpet.120.000212
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Mast Cell Degranulation Increases Mouse Mast Cell Protease 4–Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin I
Laurence Vincent, Catherine Lapointe, Modou Lo, Hugo Gagnon, Gunnar Pejler, Shinji Takai, Robert Day and Pedro D’Orléans-Juste

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 213-221; DOI: https://doi.org/10.1124/jpet.120.000325
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Predictors of Early or Delayed Diastolic Dysfunction After Anthracycline-Based or Nonanthracycline Chemotherapy: A Pharmacological Appraisal
Giorgio Minotti, Pierantonio Menna, Massimiliano Camilli, Emanuela Salvatorelli and Giorgio Reggiardo

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 231-239; DOI: https://doi.org/10.1124/jpet.120.000323

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Lysosomal Biogenesis and Implications for Hydroxychloroquine Disposition
Keagan P. Collins, Sandra Witta, Jonathan W. Coy, Yi Pang and Daniel L. Gustafson

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 294-305; DOI: https://doi.org/10.1124/jpet.120.000309

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The Novel Phosphate and Bile Acid Sequestrant Polymer SAR442357 Delays Disease Progression in a Rat Model of Diabetic Nephropathy
Tamara R. Castañeda, María Méndez, Ian Davison, Ralf Elvert, Uwe Schwahn, Galina Boldina, Corinne Rocher, Petra Scherer, Kuldeep Singh, Dinesh S. Bangari, Mechthilde Falkenhahn, Aimo Kannt, Anish Konkar, Philip J. Larsen, Cynthia Arbeeny, Pradeep K. Dhal and Thomas Hübschle

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 190-203; DOI: https://doi.org/10.1124/jpet.120.000285

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Increased Levels of Renal Lysophosphatidic Acid in Rodent Models with Renal Disease
Takashi Hirata, Stanley V. Smith, Teisuke Takahashi, Noriyuki Miyata and Richard J. Roman

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 240-249; DOI: https://doi.org/10.1124/jpet.120.000353
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Downregulation of the αvβ6 Integrin via RGD Engagement Is Affinity and Time Dependent
James A. Roper, Alex L. Wilkinson, Elaine Gower and Robert J. Slack

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 273-280; DOI: https://doi.org/10.1124/jpet.120.000379
Open Access
Activation of the G Protein–Coupled Estrogen Receptor Prevented the Development of Acute Colitis by Protecting the Crypt Cell
Qian Wang, Zhao Li, Kaixuan Liu, Jianbo Liu, Shiquan Chai, Guanyu Chen, Shuyu Wen, Tian Ming, Jiayi Wang, Yuntao Ma, Honghui Zeng, Chuanyong Liu and Bing Xue

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 281-293; DOI: https://doi.org/10.1124/jpet.120.000216

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Prostanoid Receptors of the EP₄-Subtype Mediate Gene Expression Changes in Human Airway Epithelial Cells with Potential Anti-Inflammatory Activity
Radhika Joshi, Omar Hamed, Dong Yan, Aubrey N. Michi, Mahmoud M. Mostafa, Shahina Wiehler, Robert Newton and Mark A. Giembycz

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 161-180; DOI: https://doi.org/10.1124/jpet.120.000196
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Fingolimod Phosphate (FTY720-P) Activates Protein Phosphatase 2A in Human Monocytes and Inhibits Monosodium Urate Crystal–Induced Interleukin-1β Production
Marwa Qadri, Sandy ElSayed and Khaled A. Elsaid

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 222-230; DOI: https://doi.org/10.1124/jpet.120.000321
Open Access
Sphingosine 1-Phosphate Receptor Modulator ONO-4641 Regulates Trafficking of T Lymphocytes and Hematopoietic Stem Cells and Alleviates Immune-Mediated Aplastic Anemia in a Mouse Model
Takaki Komiya, Masashi Gohda, Hiroki Shioya and Seishi Katsumata

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 250-260; DOI: https://doi.org/10.1124/jpet.120.000277

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Transport Properties of Statins by Organic Anion Transporting Polypeptide 1A2 and Regulation by Transforming Growth Factor-β Signaling in Human Endothelial Cells
Patrick T. Ronaldson, Hrvoje Brzica, Wazir Abdullahi, Bianca G. Reilly and Thomas P. Davis

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 148-160; DOI: https://doi.org/10.1124/jpet.120.000267
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Physiologically Based Pharmacokinetics of Lysosomotropic Chloroquine in Rat and Human
Xin Liu and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 261-272; DOI: https://doi.org/10.1124/jpet.120.000385

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Pharmacological Actions of Carbamate Insecticides at Mammalian Melatonin Receptors
Grant C. Glatfelter, Anthony J. Jones, Rajendram V. Rajnarayanan and Margarita L. Dubocovich

Journal of Pharmacology and Experimental Therapeutics February 2021, 376 (2) 306-321; DOI: https://doi.org/10.1124/jpet.120.000065