Journal of Pharmacology and Experimental Therapeutics: 376 (1)

January 01, 2021; Volume 376,Issue 1

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A Biomarker-Centric Approach to Drug Discovery and Development: Lessons Learned from the Coronavirus Disease 2019 Pandemic
Kelly A. Fader, Jiangwei Zhang, Joseph P. Menetski, Ravi I. Thadhani, Elliott M. Antman, Gary S. Friedman, Shashi K. Ramaiah and Vishal S. Vaidya

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 12-20; DOI: https://doi.org/10.1124/jpet.120.000204

Cardiovascular

Open Access
K_ATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema
Brittney R. Garner, Amanda J. Stolarz, Daniel Stuckey, Mustafa Sarimollaoglu, Yunmeng Liu, Philip T. Palade, Nancy J. Rusch and Shengyu Mu

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 40-50; DOI: https://doi.org/10.1124/jpet.120.000121
Open Access
Functional Interaction of Endothelin Receptors in Mediating Natriuresis Evoked by G Protein–Coupled Estrogen Receptor 1
Eman Y. Gohar and David M. Pollock

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 98-105; DOI: https://doi.org/10.1124/jpet.120.000322
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Amphetamine-like Neurochemical and Cardiovascular Effects of α-Ethylphenethylamine Analogs Found in Dietary Supplements
Charles W. Schindler, Eric B. Thorndike, John S. Partilla, Kenner C. Rice and Michael H. Baumann

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 118-126; DOI: https://doi.org/10.1124/jpet.120.000129
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Metoprolol Impairs β1-Adrenergic Receptor-Mediated Vasodilation in Rat Cerebral Arteries: Implications for β-Blocker Therapy
Christopher L. Moore, David S. Henry, Samantha J. McClenahan, Kelly K. Ball, Nancy J. Rusch and Sung W. Rhee

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 127-135; DOI: https://doi.org/10.1124/jpet.120.000176

Drug Discovery and Translational Medicine

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Downregulation of Interferon-γ Receptor Expression Endows Resistance to Anti–Programmed Death Protein 1 Therapy in Colorectal Cancer
Chunxiao Lv, Dongfen Yuan and Yanguang Cao

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 21-28; DOI: https://doi.org/10.1124/jpet.120.000284
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Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma
Polina L. Yarova, Ping Huang, Martin W. Schepelmann, Richard Bruce, Rupert Ecker, Robert Nica, Vsevolod Telezhkin, Daniela Traini, Larissa Gomes dos Reis, Emma J. Kidd, William R. Ford, Kenneth J. Broadley, Benson M. Kariuki, Christopher J. Corrigan, Jeremy P.T. Ward, Paul J. Kemp and Daniela Riccardi

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 51-63; DOI: https://doi.org/10.1124/jpet.120.000281
Open Access
Mechanistic Analysis of an Extracellular Signal–Regulated Kinase 2–Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress
Ramon Martinez, Weiliang Huang, Ramin Samadani, Bryan Mackowiak, Garrick Centola, Lijia Chen, Ivie L. Conlon, Kellie Hom, Maureen A. Kane, Steven Fletcher and Paul Shapiro

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 84-97; DOI: https://doi.org/10.1124/jpet.120.000266
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Inhibiting Sialidase-Induced TGF-β1 Activation Attenuates Pulmonary Fibrosis in Mice
Tejas R. Karhadkar, Thomas D. Meek and Richard H. Gomer

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 106-117; DOI: https://doi.org/10.1124/jpet.120.000258

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Mechanism of Diuresis and Natriuresis by Cannabinoids: Evidence for Inhibition of Na⁺-K⁺-ATPase in Mouse Kidney Thick Ascending Limb Tubules
Joseph K. Ritter, Ashfaq Ahmad, Shobha Mummalaneni, Zdravka Daneva, Sara K. Dempsey, Ningjun Li, Pin-Lan Li and Vijay Lyall

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 1-11; DOI: https://doi.org/10.1124/jpet.120.000163
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Therapeutic Effect of Neuraminidase-1–Selective Inhibition in Mouse Models of Bleomycin-Induced Pulmonary Inflammation and Fibrosis
Irina G. Luzina, Erik P. Lillehoj, Virginia Lockatell, Sang W. Hyun, Katerina N. Lugkey, Akihiro Imamura, Hideharu Ishida, Christopher W. Cairo, Sergei P. Atamas and Simeon E. Goldblum

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 136-146; DOI: https://doi.org/10.1124/jpet.120.000223

Metabolism, Transport, and Pharmacogenetics

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Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III
Sagnik Chatterjee, Sambuddho Mukherjee, L.V.J. Sankara Sivaprasad, Tanvi Naik, Shashyendra Singh Gautam, Bokka Venkata Murali, Avinash Annasao Hadambar, Gowtham Raj Gunti, Vijaykumar Kuchibhotla, Avisek Deyati, Sushma Basavanthappa, Manjunath Ramarao, T. Thanga Mariappan, Bradley A. Zinker, Yueping Zhang, Michael Sinz and Hong Shen

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 29-39; DOI: https://doi.org/10.1124/jpet.120.000291
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Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations
Rakshit S. Tanna, Dan-Dan Tian, Nadja B. Cech, Nicholas H. Oberlies, Allan E. Rettie, Kenneth E. Thummel and Mary F. Paine

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 64-73; DOI: https://doi.org/10.1124/jpet.120.000270

Toxicology

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A Preclinical Safety Study of Thyroid Hormone Instilled into the Lungs of Healthy Rats—an Investigational Therapy for ARDS
Craig M. Flory, Beverly J. Norris, Nicole A. Larson, Lia G. Coicou, Brenda L. Koniar, Margaret A. Mysz, Timothy P. Rich, David H. Ingbar and Robert J. Schumacher

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 74-83; DOI: https://doi.org/10.1124/jpet.120.000060

Erratum

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Correction to “Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor”
Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 147; DOI: https://doi.org/10.1124/jpet.119.261065err

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Cardiovascular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Metabolism, Transport, and Pharmacogenetics

Toxicology

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