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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

January 01, 2021; Volume 376,Issue 1

Minireview

  • You have access
    A Biomarker-Centric Approach to Drug Discovery and Development: Lessons Learned from the Coronavirus Disease 2019 Pandemic
    Kelly A. Fader, Jiangwei Zhang, Joseph P. Menetski, Ravi I. Thadhani, Elliott M. Antman, Gary S. Friedman, Shashi K. Ramaiah and Vishal S. Vaidya
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 12-20; DOI: https://doi.org/10.1124/jpet.120.000204

Cardiovascular

  • Open Access
    KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema
    Brittney R. Garner, Amanda J. Stolarz, Daniel Stuckey, Mustafa Sarimollaoglu, Yunmeng Liu, Philip T. Palade, Nancy J. Rusch and Shengyu Mu
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 40-50; DOI: https://doi.org/10.1124/jpet.120.000121
  • Open Access
    Functional Interaction of Endothelin Receptors in Mediating Natriuresis Evoked by G Protein–Coupled Estrogen Receptor 1
    Eman Y. Gohar and David M. Pollock
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 98-105; DOI: https://doi.org/10.1124/jpet.120.000322
  • Open Access
    Amphetamine-like Neurochemical and Cardiovascular Effects of α-Ethylphenethylamine Analogs Found in Dietary Supplements
    Charles W. Schindler, Eric B. Thorndike, John S. Partilla, Kenner C. Rice and Michael H. Baumann
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 118-126; DOI: https://doi.org/10.1124/jpet.120.000129
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    Metoprolol Impairs β1-Adrenergic Receptor-Mediated Vasodilation in Rat Cerebral Arteries: Implications for β-Blocker Therapy
    Christopher L. Moore, David S. Henry, Samantha J. McClenahan, Kelly K. Ball, Nancy J. Rusch and Sung W. Rhee
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 127-135; DOI: https://doi.org/10.1124/jpet.120.000176

Drug Discovery and Translational Medicine

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    Downregulation of Interferon-γ Receptor Expression Endows Resistance to Anti–Programmed Death Protein 1 Therapy in Colorectal Cancer
    Chunxiao Lv, Dongfen Yuan and Yanguang Cao
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 21-28; DOI: https://doi.org/10.1124/jpet.120.000284
  • Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma
    You have access
    Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma
    Polina L. Yarova, Ping Huang, Martin W. Schepelmann, Richard Bruce, Rupert Ecker, Robert Nica, Vsevolod Telezhkin, Daniela Traini, Larissa Gomes dos Reis, Emma J. Kidd, William R. Ford, Kenneth J. Broadley, Benson M. Kariuki, Christopher J. Corrigan, Jeremy P.T. Ward, Paul J. Kemp and Daniela Riccardi
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 51-63; DOI: https://doi.org/10.1124/jpet.120.000281
  • Open Access
    Mechanistic Analysis of an Extracellular Signal–Regulated Kinase 2–Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress
    Ramon Martinez, Weiliang Huang, Ramin Samadani, Bryan Mackowiak, Garrick Centola, Lijia Chen, Ivie L. Conlon, Kellie Hom, Maureen A. Kane, Steven Fletcher and Paul Shapiro
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 84-97; DOI: https://doi.org/10.1124/jpet.120.000266
  • You have access
    Inhibiting Sialidase-Induced TGF-β1 Activation Attenuates Pulmonary Fibrosis in Mice
    Tejas R. Karhadkar, Thomas D. Meek and Richard H. Gomer
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 106-117; DOI: https://doi.org/10.1124/jpet.120.000258

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Mechanism of Diuresis and Natriuresis by Cannabinoids: Evidence for Inhibition of Na+-K+-ATPase in Mouse Kidney Thick Ascending Limb Tubules
    Joseph K. Ritter, Ashfaq Ahmad, Shobha Mummalaneni, Zdravka Daneva, Sara K. Dempsey, Ningjun Li, Pin-Lan Li and Vijay Lyall
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 1-11; DOI: https://doi.org/10.1124/jpet.120.000163
  • You have access
    Therapeutic Effect of Neuraminidase-1–Selective Inhibition in Mouse Models of Bleomycin-Induced Pulmonary Inflammation and Fibrosis
    Irina G. Luzina, Erik P. Lillehoj, Virginia Lockatell, Sang W. Hyun, Katerina N. Lugkey, Akihiro Imamura, Hideharu Ishida, Christopher W. Cairo, Sergei P. Atamas and Simeon E. Goldblum
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 136-146; DOI: https://doi.org/10.1124/jpet.120.000223

Metabolism, Transport, and Pharmacogenetics

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    Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III
    Sagnik Chatterjee, Sambuddho Mukherjee, L.V.J. Sankara Sivaprasad, Tanvi Naik, Shashyendra Singh Gautam, Bokka Venkata Murali, Avinash Annasao Hadambar, Gowtham Raj Gunti, Vijaykumar Kuchibhotla, Avisek Deyati, Sushma Basavanthappa, Manjunath Ramarao, T. Thanga Mariappan, Bradley A. Zinker, Yueping Zhang, Michael Sinz and Hong Shen
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 29-39; DOI: https://doi.org/10.1124/jpet.120.000291
  • You have access
    Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations
    Rakshit S. Tanna, Dan-Dan Tian, Nadja B. Cech, Nicholas H. Oberlies, Allan E. Rettie, Kenneth E. Thummel and Mary F. Paine
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 64-73; DOI: https://doi.org/10.1124/jpet.120.000270

Toxicology

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    A Preclinical Safety Study of Thyroid Hormone Instilled into the Lungs of Healthy Rats—an Investigational Therapy for ARDS
    Craig M. Flory, Beverly J. Norris, Nicole A. Larson, Lia G. Coicou, Brenda L. Koniar, Margaret A. Mysz, Timothy P. Rich, David H. Ingbar and Robert J. Schumacher
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 74-83; DOI: https://doi.org/10.1124/jpet.120.000060

Erratum

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    Correction to “Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor”
    Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 147; DOI: https://doi.org/10.1124/jpet.119.261065err
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Journal of Pharmacology and Experimental Therapeutics: 376 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 376, Issue 1
1 Jan 2021
  • Table of Contents
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