Article Figures & Data
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Data Supplement
- Supplemental Data -
Supplementary Methods
- Supplemental Figure 1 -
Supplementary Figure 1 - LCAT activity in apoB-D plasma of FLD subjects. LCAT activity was measured on apoB-D plasma from controls (n=4, average baseline LCAT activity: 31.5 nmol/mL/h) and n=4 FLD patients (baseline LCAT activity=0 for all) after incubation with DS compound at the dose of 10 µg/mL. Data are expressed as absolute increase
- Supplemental Figure 2 -
Supplementary Figure 2 - Binding site identification. Dots represent mean positions of DS compound binding poses, colored by docking score values; the two binding sites with lowest (more favourable) energy values are highlighted by red boxes.
- Supplemental Figure 3 -
Supplementary Figure 3 - MD ligand::protein interactions. Residues that interact more than 30% of the simulated time are reported. Top panel: type of interactions, hydrogen bond (green), hydrophobic (purple), ionic (blue). Lower panel: existence matrix of interactions. Right: 2D interaction diagram.
- Supplemental Data -