Journal of Pharmacology and Experimental Therapeutics: 375 (3)

December 01, 2020; Volume 375,Issue 3

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Role of GILZ in the Kidney and the Cardiovascular System: Relevance to Cardiorenal Complications of COVID-19
Mahmood S. Mozaffari

Journal of Pharmacology and Experimental Therapeutics December 2020, 375 (3) 398-405; DOI: https://doi.org/10.1124/jpet.120.000243
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The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19
Ali Ehsan Sifat, Saeideh Nozohouri, Heidi Villalba, Bhuvaneshwar Vaidya and Thomas J. Abbruscato

Journal of Pharmacology and Experimental Therapeutics December 2020, 375 (3) 498-509; DOI: https://doi.org/10.1124/jpet.120.000170

Chemotherapy, Antibiotics, and Gene Therapy

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Time-to-Event Analysis of Paclitaxel-Associated Peripheral Neuropathy in Advanced Non–Small-Cell Lung Cancer Highlighting Key Influential Treatment/Patient Factors
Francis W. Ojara, Andrea Henrich, Nicolas Frances, Wilhelm Huisinga, Niklas Hartung, Markus Joerger and Charlotte Kloft

Journal of Pharmacology and Experimental Therapeutics December 2020, 375 (3) 430-438; DOI: https://doi.org/10.1124/jpet.120.000053

Drug Discovery and Translational Medicine

Open Access
Mechanism of Action of Veverimer: A Novel, Orally Administered, Nonabsorbed, Counterion-Free, Hydrochloric Acid Binder under Development for the Treatment of Metabolic Acidosis in Chronic Kidney Disease
Gerrit Klaerner, Jun Shao, Kalpesh Biyani, Matthew Kade, Paul Kierstead, Randi Gbur, Scott Tabakman, Son Nguyen and Jerry Buysse

Journal of Pharmacology and Experimental Therapeutics December 2020, 375 (3) 439-450; DOI: https://doi.org/10.1124/jpet.120.000190
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Activation of Naturally Occurring Lecithin:Cholesterol Acyltransferase Mutants by a Novel Activator Compound
Chiara Pavanello, Alice Ossoli, Marta Turri, Arianna Strazzella, Sara Simonelli, Tommaso Laurenzi, Keita Kono, Keisuke Yamada, Naoki Kiyosawa, Ivano Eberini and Laura Calabresi

Journal of Pharmacology and Experimental Therapeutics December 2020, 375 (3) 463-468; DOI: https://doi.org/10.1124/jpet.120.000159
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Monoclonal Antibodies Counteract Opioid-Induced Behavioral and Toxic Effects in Mice and Rats
Carly Baehr, April Huseby Kelcher, Aaron Khaimraj, Dana E. Reed, Sujata G. Pandit, David AuCoin, Saadyah Averick and Marco Pravetoni

Journal of Pharmacology and Experimental Therapeutics December 2020, 375 (3) 469-477; DOI: https://doi.org/10.1124/jpet.120.000124
Open Access
Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits
Weimei Sun, Xuqing Zhang, Maxwell D. Cummings, Kamal Albarazanji, Jiejun Wu, Mina Wang, Richard Alexander, Bin Zhu, YueMei Zhang, James Leonard, James Lanter and James Lenhard

Journal of Pharmacology and Experimental Therapeutics December 2020, 375 (3) 510-521; DOI: https://doi.org/10.1124/jpet.120.000219

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note
Tilman Pfeffer, Ettore Lignelli, Hajime Inoue, Ivana Mižíková, David E. Surate Solaligue, Heiko Steenbock, Despoina Myti, István Vadász, Susanne Herold, Werner Seeger, Jürgen Brinckmann and Rory E. Morty

Journal of Pharmacology and Experimental Therapeutics December 2020, 375 (3) 478-487; DOI: https://doi.org/10.1124/jpet.120.000138

Inflammation, Immunopharmacology, and Asthma

Open Access
An Evaluation of the Activity of Histidine-Rich Glycoprotein on Differentiated Neutrophil-Like Cells from Human Cell Lines
Yukinori Yoshii, Hidenori Wake, Yoshito Nishimura, Kiyoshi Teshigawara, Dengli Wang and Masahiro Nishibori

Journal of Pharmacology and Experimental Therapeutics December 2020, 375 (3) 406-413; DOI: https://doi.org/10.1124/jpet.120.000182
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The Phosphodiesterase Inhibitor Ensifentrine Reduces Production of Proinflammatory Mediators in Well Differentiated Bronchial Epithelial Cells by Inhibiting PDE4
Mark J. Turner, Nurlan Dauletbaev, Larry C. Lands and John W. Hanrahan

Journal of Pharmacology and Experimental Therapeutics December 2020, 375 (3) 414-429; DOI: https://doi.org/10.1124/jpet.120.000080
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Adalimumab Immunogenicity Is Negatively Correlated with Anti-Hinge Antibody Levels in Patients with Rheumatoid Arthritis
Keito Hoshitsuki, Sanjay Rathod, Manda J. Ramsey, Lei Zhu, Larry W. Moreland and Christian A. Fernandez

Journal of Pharmacology and Experimental Therapeutics December 2020, 375 (3) 488-497; DOI: https://doi.org/10.1124/jpet.120.000179

Metabolism, Transport, and Pharmacogenetics

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Interaction of Halogenated Tyrosine/Phenylalanine Derivatives with Organic Anion Transporter 1 in the Renal Handling of Tumor Imaging Probes
Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Minhui Xu, Suguru Okuda, Hiroki Okanishi, Yasuharu Kawamoto, Xin He, Shushi Nagamori and Yoshikatsu Kanai

Journal of Pharmacology and Experimental Therapeutics December 2020, 375 (3) 451-462; DOI: https://doi.org/10.1124/jpet.120.000235

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Table of Contents

Minireview

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenetics

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