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Research ArticleDrug Discovery and Translational Medicine
Open Access

Utilizing Designed Receptors Exclusively Activated by Designer Drug Chemogenetic Tools to Identify Beneficial G Protein–Coupled Receptor Signaling for Fibrosis

Ji Zhang, Eyal Vardy, Eric S. Muise, Tzu-Ming Wang, Richard Visconti, Ashita Vadlamudi, Shirly Pinto and Andrea M. Peier
Journal of Pharmacology and Experimental Therapeutics November 2020, 375 (2) 357-366; DOI: https://doi.org/10.1124/jpet.120.000103
Ji Zhang
Departments of Cardiometabolic Diseases (J.Z., S.P.), Screening and Compound Profiling (E.V., R.V., A.V., A.M.P.), GpGx (E.S.M.), and Translational Biomarkers (T.-M.W.), MRL, Merck & Co., Inc., Kenilworth, New Jersey; and Kallyope Inc., New York, New York (E.V., S.P.)
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Eyal Vardy
Departments of Cardiometabolic Diseases (J.Z., S.P.), Screening and Compound Profiling (E.V., R.V., A.V., A.M.P.), GpGx (E.S.M.), and Translational Biomarkers (T.-M.W.), MRL, Merck & Co., Inc., Kenilworth, New Jersey; and Kallyope Inc., New York, New York (E.V., S.P.)
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Eric S. Muise
Departments of Cardiometabolic Diseases (J.Z., S.P.), Screening and Compound Profiling (E.V., R.V., A.V., A.M.P.), GpGx (E.S.M.), and Translational Biomarkers (T.-M.W.), MRL, Merck & Co., Inc., Kenilworth, New Jersey; and Kallyope Inc., New York, New York (E.V., S.P.)
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Tzu-Ming Wang
Departments of Cardiometabolic Diseases (J.Z., S.P.), Screening and Compound Profiling (E.V., R.V., A.V., A.M.P.), GpGx (E.S.M.), and Translational Biomarkers (T.-M.W.), MRL, Merck & Co., Inc., Kenilworth, New Jersey; and Kallyope Inc., New York, New York (E.V., S.P.)
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Richard Visconti
Departments of Cardiometabolic Diseases (J.Z., S.P.), Screening and Compound Profiling (E.V., R.V., A.V., A.M.P.), GpGx (E.S.M.), and Translational Biomarkers (T.-M.W.), MRL, Merck & Co., Inc., Kenilworth, New Jersey; and Kallyope Inc., New York, New York (E.V., S.P.)
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Ashita Vadlamudi
Departments of Cardiometabolic Diseases (J.Z., S.P.), Screening and Compound Profiling (E.V., R.V., A.V., A.M.P.), GpGx (E.S.M.), and Translational Biomarkers (T.-M.W.), MRL, Merck & Co., Inc., Kenilworth, New Jersey; and Kallyope Inc., New York, New York (E.V., S.P.)
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Shirly Pinto
Departments of Cardiometabolic Diseases (J.Z., S.P.), Screening and Compound Profiling (E.V., R.V., A.V., A.M.P.), GpGx (E.S.M.), and Translational Biomarkers (T.-M.W.), MRL, Merck & Co., Inc., Kenilworth, New Jersey; and Kallyope Inc., New York, New York (E.V., S.P.)
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Andrea M. Peier
Departments of Cardiometabolic Diseases (J.Z., S.P.), Screening and Compound Profiling (E.V., R.V., A.V., A.M.P.), GpGx (E.S.M.), and Translational Biomarkers (T.-M.W.), MRL, Merck & Co., Inc., Kenilworth, New Jersey; and Kallyope Inc., New York, New York (E.V., S.P.)
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Article Information

vol. 375 no. 2 357-366
DOI 
https://doi.org/10.1124/jpet.120.000103
PubMed 
32848074

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received May 12, 2020
  • Accepted August 4, 2020
  • Published online October 28, 2020.

Article Versions

  • Earlier version (August 26, 2020 - 14:13).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2020 by The Author(s) This is an open access article distributed under the CC BY Attribution 4.0 International license.

Author Information

  1. Ji Zhang1,
  2. Eyal Vardy1,
  3. Eric S. Muise,
  4. Tzu-Ming Wang,
  5. Richard Visconti,
  6. Ashita Vadlamudi,
  7. Shirly Pinto, and
  8. Andrea M. Peier
  1. Departments of Cardiometabolic Diseases (J.Z., S.P.), Screening and Compound Profiling (E.V., R.V., A.V., A.M.P.), GpGx (E.S.M.), and Translational Biomarkers (T.-M.W.), MRL, Merck & Co., Inc., Kenilworth, New Jersey; and Kallyope Inc., New York, New York (E.V., S.P.)
  1. Address correspondence to:
    Andrea M. Peier, Departments of Screening and Compound Profiling, MRL, Merck & Co., Inc., 2000 Galloping Hill Rd., Kenilworth, NJ 07033. E-mail: andrea_peier{at}merck.com; or
  2. Ji Zhang, Departments of Cardiometabolic Diseases, MRL, Merck & Co., Inc., 2000 Galloping Hill Rd., Kenilworth, NJ 07033. E-mail: jzhang30{at}gmail.com
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Journal of Pharmacology and Experimental Therapeutics: 375 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 375, Issue 2
1 Nov 2020
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Research ArticleDrug Discovery and Translational Medicine

GPCR Signaling in Fibrosis

Ji Zhang, Eyal Vardy, Eric S. Muise, Tzu-Ming Wang, Richard Visconti, Ashita Vadlamudi, Shirly Pinto and Andrea M. Peier
Journal of Pharmacology and Experimental Therapeutics November 1, 2020, 375 (2) 357-366; DOI: https://doi.org/10.1124/jpet.120.000103

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Research ArticleDrug Discovery and Translational Medicine

GPCR Signaling in Fibrosis

Ji Zhang, Eyal Vardy, Eric S. Muise, Tzu-Ming Wang, Richard Visconti, Ashita Vadlamudi, Shirly Pinto and Andrea M. Peier
Journal of Pharmacology and Experimental Therapeutics November 1, 2020, 375 (2) 357-366; DOI: https://doi.org/10.1124/jpet.120.000103
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