Review ArticleMinireview
Strategies for Developing κ Opioid Receptor Agonists for the Treatment of Pain with Fewer Side Effects
Kelly F. Paton, Diana V. Atigari, Sophia Kaska, Thomas Prisinzano and Bronwyn M. Kivell
Journal of Pharmacology and Experimental Therapeutics November 2020, 375 (2) 332-348; DOI: https://doi.org/10.1124/jpet.120.000134
Kelly F. Paton
School of Biological Sciences, Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand (K.P., D.V.A., B.M.K.) and Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky (S.K., T.P.)
Diana V. Atigari
School of Biological Sciences, Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand (K.P., D.V.A., B.M.K.) and Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky (S.K., T.P.)
Sophia Kaska
School of Biological Sciences, Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand (K.P., D.V.A., B.M.K.) and Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky (S.K., T.P.)
Thomas Prisinzano
School of Biological Sciences, Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand (K.P., D.V.A., B.M.K.) and Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky (S.K., T.P.)
Bronwyn M. Kivell
School of Biological Sciences, Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand (K.P., D.V.A., B.M.K.) and Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky (S.K., T.P.)
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In this issue
Review ArticleMinireview
Strategies for Developing Safer κ Opioid Receptor Agonists
Kelly F. Paton, Diana V. Atigari, Sophia Kaska, Thomas Prisinzano and Bronwyn M. Kivell
Journal of Pharmacology and Experimental Therapeutics November 1, 2020, 375 (2) 332-348; DOI: https://doi.org/10.1124/jpet.120.000134
Review ArticleMinireview
Strategies for Developing Safer κ Opioid Receptor Agonists
Kelly F. Paton, Diana V. Atigari, Sophia Kaska, Thomas Prisinzano and Bronwyn M. Kivell
Journal of Pharmacology and Experimental Therapeutics November 1, 2020, 375 (2) 332-348; DOI: https://doi.org/10.1124/jpet.120.000134
Jump to section
- Article
- Abstract
- Introduction
- κ Opioid Receptor Signaling and the Role in Pain
- Traditional Arylacetamide κ Opioid Receptor Agonists
- Strategies to Develop κ Opioid Receptor Agonists with Reduced Side Effects
- G-Protein–Biased κ Opioid Receptor Agonists
- Peripherally Restricted κ Opioid Receptor Agonists
- Mixed κ Opioid Receptor Agonists
- Conclusions
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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