Abstract
Mononuclear macrophages derived from the bone marrow (myeloid cells) are key cellular components of the innate immune system in different organs. In this minireview, we are focused on both brain and blood macrophages, known as microglia and monocytes, respectively. We provide a succinct summary of the cells’ functions under both normal and pathologic conditions, with particular reference to common neurodegenerative disorders, such as Alzheimer and Parkinson disease.
SIGNIFICANCE STATEMENT In this minireview, we aim to summarize available literature on microglial and myeloid involvement in CNS disease, directing the reader toward relevant and translatable interpretations of myeloid cell function in CNS health and neurodegeneration.
Footnotes
- Received January 7, 2020.
- Accepted March 27, 2020.
We acknowledge funding from University of Florida Research Developmental Fund (Moonshot), from the Fixel Institute for Neurologic Diseases, and from National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke Grants 2R01-NS071122-07A1 to H.K.; shared instrumentation Grant S10OD020026 and Grant 8AZ19 awarded to W.J.S. from the Florida Department of Health; and multi-PI 5R21NS103108-02 awarded to H.K. and W.J.S. We also acknowledge funding from the National Center for Advancing Translational Sciences of the NIH under University of Florida Clinical and Translational Science Awards TL1TR001428 and UL1TR001427. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
- Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics
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In this issue
Microglia and Other Myeloid Cells in CNS Health and Disease
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- Peripheral Myeloid Cell Subtypes
- Neuroimmune Cells in the Healthy Brain
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- Alzheimer Disease
- Parkinson Disease
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