Research ArticleMinireview
Open Access
Drug Discovery Strategies for SARS-CoV-2
Zeenat A. Shyr, Kirill Gorshkov, Catherine Z. Chen and Wei Zheng
Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 127-138; DOI: https://doi.org/10.1124/jpet.120.000123
Zeenat A. Shyr
National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland
Kirill Gorshkov
National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland
Catherine Z. Chen
National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland
Wei Zheng
National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland

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Research ArticleMinireview
SARS-CoV-2 Drug Discovery
Zeenat A. Shyr, Kirill Gorshkov, Catherine Z. Chen and Wei Zheng
Journal of Pharmacology and Experimental Therapeutics October 1, 2020, 375 (1) 127-138; DOI: https://doi.org/10.1124/jpet.120.000123
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- Article
- Abstract
- Introduction
- Overview of SARS-CoV-2 Genome and Protein Constituents
- Viral Entry Through the Binding of SARS-CoV-2 Spike Proteins to Angiotensin Converting Enzyme 2 Receptor
- SARS-CoV-2 Has Multiple Viral Entry Mechanisms
- Drug Development Strategies
- SARS-CoV-2 Viral Entry Inhibitors
- Viral Replication Inhibitors
- Host Cell and Viral Targets for Antiviral Drug Development
- Prophylactic Treatment of SARS-CoV-2 Infection
- Other Treatments in Clinical Trials for COVID-19
- Vaccines for SARS-CoV-2
- Perspectives and Conclusion
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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