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Research ArticleMinireview
Open Access

Drug Discovery Strategies for SARS-CoV-2

Zeenat A. Shyr, Kirill Gorshkov, Catherine Z. Chen and Wei Zheng
Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 127-138; DOI: https://doi.org/10.1124/jpet.120.000123
Zeenat A. Shyr
National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland
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Kirill Gorshkov
National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland
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Catherine Z. Chen
National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland
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Wei Zheng
National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland
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Article Information

vol. 375 no. 1 127-138
DOI 
https://doi.org/10.1124/jpet.120.000123
PubMed 
32723801

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received May 21, 2020
  • Accepted July 10, 2020
  • Published online September 19, 2020.

Article Versions

  • Earlier version (July 28, 2020 - 16:31).
  • You are viewing the most recent version of this article.
Copyright & Usage 
U.S. Government work not protected by U.S. copyright

Author Information

  1. Zeenat A. Shyr,
  2. Kirill Gorshkov,
  3. Catherine Z. Chen, and
  4. Wei Zheng
  1. National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland
  1. Address correspondence to:
    Dr. Wei Zheng, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, MSC: 3375, Bethesda, MD. E-mail: wzheng{at}mail.nih.gov
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Journal of Pharmacology and Experimental Therapeutics: 375 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 375, Issue 1
1 Oct 2020
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Research ArticleMinireview

SARS-CoV-2 Drug Discovery

Zeenat A. Shyr, Kirill Gorshkov, Catherine Z. Chen and Wei Zheng
Journal of Pharmacology and Experimental Therapeutics October 1, 2020, 375 (1) 127-138; DOI: https://doi.org/10.1124/jpet.120.000123

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Research ArticleMinireview

SARS-CoV-2 Drug Discovery

Zeenat A. Shyr, Kirill Gorshkov, Catherine Z. Chen and Wei Zheng
Journal of Pharmacology and Experimental Therapeutics October 1, 2020, 375 (1) 127-138; DOI: https://doi.org/10.1124/jpet.120.000123
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  • Article
    • Abstract
    • Introduction
    • Overview of SARS-CoV-2 Genome and Protein Constituents
    • Viral Entry Through the Binding of SARS-CoV-2 Spike Proteins to Angiotensin Converting Enzyme 2 Receptor
    • SARS-CoV-2 Has Multiple Viral Entry Mechanisms
    • Drug Development Strategies
    • SARS-CoV-2 Viral Entry Inhibitors
    • Viral Replication Inhibitors
    • Host Cell and Viral Targets for Antiviral Drug Development
    • Prophylactic Treatment of SARS-CoV-2 Infection
    • Other Treatments in Clinical Trials for COVID-19
    • Vaccines for SARS-CoV-2
    • Perspectives and Conclusion
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
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  • eLetters
  • PDF

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