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Research ArticleToxicology

Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supralethal Dose of Soman in Cynomolgus Monkeys Posttreated with Conventional Antidotes

Malcolm Lane, D’Arice Carter, Joseph D. Pescrille, Yasco Aracava, William P. Fawcett, G. William Basinger, Edna F.R. Pereira and Edson X. Albuquerque
Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 115-126; DOI: https://doi.org/10.1124/jpet.120.265843
Malcolm Lane
Division of Translational Toxicology, Department of Epidemiology and Public Health (M.L., D.C., J.D.P., Y.A., W.P.F., E.F.R.P., E.X.A.) and Department of Pharmacology (E.F.R.P., E.X.A.), University of Maryland School of Medicine, Baltimore, Maryland; and Countervail Corp., Charlotte, North Carolina (G.W.B.)
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D’Arice Carter
Division of Translational Toxicology, Department of Epidemiology and Public Health (M.L., D.C., J.D.P., Y.A., W.P.F., E.F.R.P., E.X.A.) and Department of Pharmacology (E.F.R.P., E.X.A.), University of Maryland School of Medicine, Baltimore, Maryland; and Countervail Corp., Charlotte, North Carolina (G.W.B.)
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Joseph D. Pescrille
Division of Translational Toxicology, Department of Epidemiology and Public Health (M.L., D.C., J.D.P., Y.A., W.P.F., E.F.R.P., E.X.A.) and Department of Pharmacology (E.F.R.P., E.X.A.), University of Maryland School of Medicine, Baltimore, Maryland; and Countervail Corp., Charlotte, North Carolina (G.W.B.)
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Yasco Aracava
Division of Translational Toxicology, Department of Epidemiology and Public Health (M.L., D.C., J.D.P., Y.A., W.P.F., E.F.R.P., E.X.A.) and Department of Pharmacology (E.F.R.P., E.X.A.), University of Maryland School of Medicine, Baltimore, Maryland; and Countervail Corp., Charlotte, North Carolina (G.W.B.)
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William P. Fawcett
Division of Translational Toxicology, Department of Epidemiology and Public Health (M.L., D.C., J.D.P., Y.A., W.P.F., E.F.R.P., E.X.A.) and Department of Pharmacology (E.F.R.P., E.X.A.), University of Maryland School of Medicine, Baltimore, Maryland; and Countervail Corp., Charlotte, North Carolina (G.W.B.)
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G. William Basinger
Division of Translational Toxicology, Department of Epidemiology and Public Health (M.L., D.C., J.D.P., Y.A., W.P.F., E.F.R.P., E.X.A.) and Department of Pharmacology (E.F.R.P., E.X.A.), University of Maryland School of Medicine, Baltimore, Maryland; and Countervail Corp., Charlotte, North Carolina (G.W.B.)
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Edna F.R. Pereira
Division of Translational Toxicology, Department of Epidemiology and Public Health (M.L., D.C., J.D.P., Y.A., W.P.F., E.F.R.P., E.X.A.) and Department of Pharmacology (E.F.R.P., E.X.A.), University of Maryland School of Medicine, Baltimore, Maryland; and Countervail Corp., Charlotte, North Carolina (G.W.B.)
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Edson X. Albuquerque
Division of Translational Toxicology, Department of Epidemiology and Public Health (M.L., D.C., J.D.P., Y.A., W.P.F., E.F.R.P., E.X.A.) and Department of Pharmacology (E.F.R.P., E.X.A.), University of Maryland School of Medicine, Baltimore, Maryland; and Countervail Corp., Charlotte, North Carolina (G.W.B.)
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Article Information

vol. 375 no. 1 115-126
DOI 
https://doi.org/10.1124/jpet.120.265843
PubMed 
32759369

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 24, 2020
  • Accepted July 28, 2020
  • Published online September 16, 2020.

Article Versions

  • Earlier version (August 5, 2020 - 09:19).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Malcolm Lane,
  2. D’Arice Carter,
  3. Joseph D. Pescrille,
  4. Yasco Aracava,
  5. William P. Fawcett,
  6. G. William Basinger,
  7. Edna F.R. Pereira1, and
  8. Edson X. Albuquerque1
  1. Division of Translational Toxicology, Department of Epidemiology and Public Health (M.L., D.C., J.D.P., Y.A., W.P.F., E.F.R.P., E.X.A.) and Department of Pharmacology (E.F.R.P., E.X.A.), University of Maryland School of Medicine, Baltimore, Maryland; and Countervail Corp., Charlotte, North Carolina (G.W.B.)
  1. Address correspondence to:
    Dr. Edna F.R. Pereira, 10 S. Pine St. MSTF Suite 900, Baltimore, MD 21201. E-mail: epereira{at}som.umaryland.edu
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Journal of Pharmacology and Experimental Therapeutics: 375 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 375, Issue 1
1 Oct 2020
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Research ArticleToxicology

Galantamine Prevents Soman Poisoning in Cynomolgus Monkeys

Malcolm Lane, D’Arice Carter, Joseph D. Pescrille, Yasco Aracava, William P. Fawcett, G. William Basinger, Edna F.R. Pereira and Edson X. Albuquerque
Journal of Pharmacology and Experimental Therapeutics October 1, 2020, 375 (1) 115-126; DOI: https://doi.org/10.1124/jpet.120.265843

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Research ArticleToxicology

Galantamine Prevents Soman Poisoning in Cynomolgus Monkeys

Malcolm Lane, D’Arice Carter, Joseph D. Pescrille, Yasco Aracava, William P. Fawcett, G. William Basinger, Edna F.R. Pereira and Edson X. Albuquerque
Journal of Pharmacology and Experimental Therapeutics October 1, 2020, 375 (1) 115-126; DOI: https://doi.org/10.1124/jpet.120.265843
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