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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

October 01, 2020; Volume 375,Issue 1

Special Section on Sexual Dimorphism in Neuroimmune Cells

  • You have access
    Sexual Dimorphism of Neuroimmune Cells and Its Impact on the Central Nervous System: a Special Issue
    Luisa Torres and Stella E. Tsirka
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 152-153; DOI: https://doi.org/10.1124/jpet.120.000261
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    Microglia and Other Myeloid Cells in Central Nervous System Health and Disease
    Adithya Gopinath, Anthony Collins, Habibeh Khoshbouei and Wolfgang J. Streit
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 154-160; DOI: https://doi.org/10.1124/jpet.120.265058
  • You have access
    Sex Differences in the Inflammatory Consequences of Stress: Implications for Pharmacotherapy
    Gustavo A. Martinez-Muniz and Susan K. Wood
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 161-174; DOI: https://doi.org/10.1124/jpet.120.266205
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    Neuroimmune Mechanisms and Sex/Gender-Dependent Effects in the Pathophysiology of Mental Disorders
    Alexandros G. Kokkosis and Stella E. Tsirka
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 175-192; DOI: https://doi.org/10.1124/jpet.120.266163
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    Effects of the α-2 Adrenergic Receptor Agonists Lofexidine and Guanfacine on Food-Cocaine Choice in Socially Housed Cynomolgus Monkeys
    Paul W. Czoty and Michael A. Nader
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 193-201; DOI: https://doi.org/10.1124/jpet.120.266007
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    Sex-Dependent Mechanisms of Chronic Pain: A Focus on Microglia and P2X4R
    Katherine Halievski, Shahrzad Ghazisaeidi and Michael W. Salter
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 202-209; DOI: https://doi.org/10.1124/jpet.120.265017
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    Sex- and Region-Specific Differences in the Transcriptomes of Rat Microglia from the Brainstem and Cervical Spinal Cord
    Andrea C. Ewald, Elizabeth A. Kiernan, Avtar S. Roopra, Abigail B. Radcliff, Rebecca R. Timko, Tracy L. Baker and Jyoti J. Watters
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 210-222; DOI: https://doi.org/10.1124/jpet.120.266171
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    Shaping Microglial Phenotypes Through Estrogen Receptors: Relevance to Sex-Specific Neuroinflammatory Responses to Brain Injury and Disease
    Maricedes Acosta-Martínez
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 223-236; DOI: https://doi.org/10.1124/jpet.119.264598

Minireview

  • Open Access
    Drug Discovery Strategies for SARS-CoV-2
    Zeenat A. Shyr, Kirill Gorshkov, Catherine Z. Chen and Wei Zheng
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 127-138; DOI: https://doi.org/10.1124/jpet.120.000123

Behavioral Pharmacology

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    Mirtazapine, an α2 Antagonist-Type Antidepressant, Reverses Pain and Lack of Morphine Analgesia in Fibromyalgia-Like Mouse Models
    Hiroyuki Neyama, Naoki Dozono, Hitoshi Uchida and Hiroshi Ueda
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 1-9; DOI: https://doi.org/10.1124/jpet.120.265942
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    Sialorphin Potentiates Effects of [Met5]Enkephalin without Toxicity by Action other than Peptidase Inhibition
    Takugi Kan, Masanobu Yoshikawa, Mariko Watanabe, Masaaki Miura, Kenji Ito, Mitsumasa Matsuda, Kayoko Iwao, Hiroyuki Kobayashi, Takeshi Suzuki and Toshiyasu Suzuki
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 104-114; DOI: https://doi.org/10.1124/jpet.120.266080

Cardiovascular

  • Open Access
    Microsomal Prostaglandin E2 Synthase-1 Deletion Attenuates Isoproterenol-Induced Myocardial Fibrosis in Mice
    Shuang Ji, Rui Guo, Jing Wang, Lei Qian, Min Liu, Hu Xu, Jiayang Zhang, Youfei Guan, Guangrui Yang and Lihong Chen
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 40-48; DOI: https://doi.org/10.1124/jpet.120.000023

Cellular and Molecular

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    New Proline, Alanine, Serine Repeat Sequence for Pharmacokinetic Enhancement of Anti-VEGF Single-Domain Antibody
    Farnaz Khodabakhsh, Morteza Salimian, Ardavan Mehdizadeh, Mohammad Sadeq Khosravy, Alireza Vafabakhsh, Elmira Karami and Reza Ahangari Cohan
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 69-75; DOI: https://doi.org/10.1124/jpet.120.000012

Drug Discovery and Translational Medicine

  • Semi-Mechanistic Pharmacokinetic Modeling of Lipid Core Nanocapsules: Understanding Quetiapine Plasma and Brain Disposition in a Neurodevelopmental Animal Model of Schizophrenia
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    Semi-Mechanistic Pharmacokinetic Modeling of Lipid Core Nanocapsules: Understanding Quetiapine Plasma and Brain Disposition in a Neurodevelopmental Animal Model of Schizophrenia
    Fernando Carreño, Victória Eteges Helfer, Keli Jaqueline Staudt, Laura Bem Olivo, Karina Paese, Fabíola Schons Meyer, Ana Paula Herrmann, Sílvia Stanisçuaski Guterres, Stela Mari Kuze Rates, Iñaki Trocóniz and Teresa Dalla Costa
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 49-58; DOI: https://doi.org/10.1124/jpet.120.000109
  • Open Access
    Delayed Adjunctive Treatment of Organophosphate-Induced Status Epilepticus in Rats with Phenobarbital, Memantine, or Dexmedetomidine
    Jay Spampanato, Steven L. Bealer, Melissa Smolik and F. Edward Dudek
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 59-68; DOI: https://doi.org/10.1124/jpet.120.000175

Endocrine and Diabetes

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    Dextromethorphan and Dextrorphan Influence Insulin Secretion by Interacting with KATP and L-type Ca2+ Channels in Pancreatic β-Cells
    Anne Gresch and Martina Düfer
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 10-20; DOI: https://doi.org/10.1124/jpet.120.265835

Gastrointestinal, Hepatic, Pulmonary, and Renal

  • Open Access
    The GPR40 Full Agonist SCO-267 Improves Liver Parameters in a Mouse Model of Nonalcoholic Fatty Liver Disease without Affecting Glucose or Body Weight
    Mitsugi Ookawara, Keisuke Matsuda, Masanori Watanabe and Yusuke Moritoh
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 21-27; DOI: https://doi.org/10.1124/jpet.120.000046
  • Open Access
    Gender-Related Differences of Tachykinin NK2 Receptor Expression and Activity in Human Colonic Smooth Muscle
    Stelina Drimousis, Irit Markus, Tim V. Murphy, D. Shevy Perera, Kim-Chi Phan-Thien, Li Zhang and Lu Liu
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 28-39; DOI: https://doi.org/10.1124/jpet.120.265967
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    Renal Effects of Dapagliflozin in People with and without Diabetes with Moderate or Severe Renal Dysfunction: Prospective Modeling of an Ongoing Clinical Trial
    K. Melissa Hallow, David W. Boulton, Robert C. Penland, Gabriel Helmlinger, Emily H. Nieves, Daniël H. van Raalte, Hiddo L. Heerspink and Peter J. Greasley
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 76-91; DOI: https://doi.org/10.1124/jpet.120.000040
  • Open Access
    Potent Therapy and Transcriptional Profile of Combined Erythropoietin-Derived Peptide Cyclic Helix B Surface Peptide and Caspase-3 siRNA against Kidney Ischemia/Reperfusion Injury in Mice
    Yuanyuan Wu, Weiwei Chen, Yufang Zhang, Aifen Liu, Cheng Yang, Hui Wang, Tongyu Zhu, Yaping Fan and Bin Yang
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 92-103; DOI: https://doi.org/10.1124/jpet.120.000092

Metabolism, Transport, and Pharmacogenetics

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    Absence of OATP1B (Organic Anion–Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression
    Yueping Zhang, Cliff Chen, Shen-Jue Chen, Xue-Qing Chen, David J. Shuster, Pawel D. Puszczalo, R. Marcus Fancher, Zheng Yang, Michael Sinz and Hong Shen
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 139-151; DOI: https://doi.org/10.1124/jpet.120.000139

Toxicology

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    Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supralethal Dose of Soman in Cynomolgus Monkeys Posttreated with Conventional Antidotes
    Malcolm Lane, D’Arice Carter, Joseph D. Pescrille, Yasco Aracava, William P. Fawcett, G. William Basinger, Edna F.R. Pereira and Edson X. Albuquerque
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 115-126; DOI: https://doi.org/10.1124/jpet.120.265843

Errata

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    Correction to “The GPR40 Full Agonist SCO-267 Improves Liver Parameters in a Mouse Model of Nonalcoholic Fatty Liver Disease without Affecting Glucose or Body Weight”
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 237; DOI: https://doi.org/10.1124/jpet.120.000046err
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    Correction to “Translational Pharmacokinetic-Pharmacodynamic Modeling for an Orally Available Novel Inhibitor of Epigenetic Regulator Enhancer of Zeste Homolog 2”
    Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 238; DOI: https://doi.org/10.1124/jpet.119.263491err
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 375 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 375, Issue 1
1 Oct 2020
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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Jump to

  • Special Section on Sexual Dimorphism in Neuroimmune Cells
  • Minireview
  • Behavioral Pharmacology
  • Cardiovascular
  • Cellular and Molecular
  • Drug Discovery and Translational Medicine
  • Endocrine and Diabetes
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Metabolism, Transport, and Pharmacogenetics
  • Toxicology
  • Errata
  • Most Cited
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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