Journal of Pharmacology and Experimental Therapeutics: 375 (1)

October 01, 2020; Volume 375,Issue 1

Special Section on Sexual Dimorphism in Neuroimmune Cells

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Sexual Dimorphism of Neuroimmune Cells and Its Impact on the Central Nervous System: a Special Issue
Luisa Torres and Stella E. Tsirka

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 152-153; DOI: https://doi.org/10.1124/jpet.120.000261
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Microglia and Other Myeloid Cells in Central Nervous System Health and Disease
Adithya Gopinath, Anthony Collins, Habibeh Khoshbouei and Wolfgang J. Streit

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 154-160; DOI: https://doi.org/10.1124/jpet.120.265058
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Sex Differences in the Inflammatory Consequences of Stress: Implications for Pharmacotherapy
Gustavo A. Martinez-Muniz and Susan K. Wood

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 161-174; DOI: https://doi.org/10.1124/jpet.120.266205
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Neuroimmune Mechanisms and Sex/Gender-Dependent Effects in the Pathophysiology of Mental Disorders
Alexandros G. Kokkosis and Stella E. Tsirka

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 175-192; DOI: https://doi.org/10.1124/jpet.120.266163
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Effects of the α-2 Adrenergic Receptor Agonists Lofexidine and Guanfacine on Food-Cocaine Choice in Socially Housed Cynomolgus Monkeys
Paul W. Czoty and Michael A. Nader

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 193-201; DOI: https://doi.org/10.1124/jpet.120.266007
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Sex-Dependent Mechanisms of Chronic Pain: A Focus on Microglia and P2X4R
Katherine Halievski, Shahrzad Ghazisaeidi and Michael W. Salter

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 202-209; DOI: https://doi.org/10.1124/jpet.120.265017
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Sex- and Region-Specific Differences in the Transcriptomes of Rat Microglia from the Brainstem and Cervical Spinal Cord
Andrea C. Ewald, Elizabeth A. Kiernan, Avtar S. Roopra, Abigail B. Radcliff, Rebecca R. Timko, Tracy L. Baker and Jyoti J. Watters

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 210-222; DOI: https://doi.org/10.1124/jpet.120.266171
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Shaping Microglial Phenotypes Through Estrogen Receptors: Relevance to Sex-Specific Neuroinflammatory Responses to Brain Injury and Disease
Maricedes Acosta-Martínez

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 223-236; DOI: https://doi.org/10.1124/jpet.119.264598

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Open Access
Drug Discovery Strategies for SARS-CoV-2
Zeenat A. Shyr, Kirill Gorshkov, Catherine Z. Chen and Wei Zheng

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 127-138; DOI: https://doi.org/10.1124/jpet.120.000123

Behavioral Pharmacology

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Mirtazapine, an α2 Antagonist-Type Antidepressant, Reverses Pain and Lack of Morphine Analgesia in Fibromyalgia-Like Mouse Models
Hiroyuki Neyama, Naoki Dozono, Hitoshi Uchida and Hiroshi Ueda

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 1-9; DOI: https://doi.org/10.1124/jpet.120.265942
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Sialorphin Potentiates Effects of [Met⁵]Enkephalin without Toxicity by Action other than Peptidase Inhibition
Takugi Kan, Masanobu Yoshikawa, Mariko Watanabe, Masaaki Miura, Kenji Ito, Mitsumasa Matsuda, Kayoko Iwao, Hiroyuki Kobayashi, Takeshi Suzuki and Toshiyasu Suzuki

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 104-114; DOI: https://doi.org/10.1124/jpet.120.266080

Cardiovascular

Open Access
Microsomal Prostaglandin E₂ Synthase-1 Deletion Attenuates Isoproterenol-Induced Myocardial Fibrosis in Mice
Shuang Ji, Rui Guo, Jing Wang, Lei Qian, Min Liu, Hu Xu, Jiayang Zhang, Youfei Guan, Guangrui Yang and Lihong Chen

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 40-48; DOI: https://doi.org/10.1124/jpet.120.000023

Cellular and Molecular

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New Proline, Alanine, Serine Repeat Sequence for Pharmacokinetic Enhancement of Anti-VEGF Single-Domain Antibody
Farnaz Khodabakhsh, Morteza Salimian, Ardavan Mehdizadeh, Mohammad Sadeq Khosravy, Alireza Vafabakhsh, Elmira Karami and Reza Ahangari Cohan

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 69-75; DOI: https://doi.org/10.1124/jpet.120.000012

Drug Discovery and Translational Medicine

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Semi-Mechanistic Pharmacokinetic Modeling of Lipid Core Nanocapsules: Understanding Quetiapine Plasma and Brain Disposition in a Neurodevelopmental Animal Model of Schizophrenia
Fernando Carreño, Victória Eteges Helfer, Keli Jaqueline Staudt, Laura Bem Olivo, Karina Paese, Fabíola Schons Meyer, Ana Paula Herrmann, Sílvia Stanisçuaski Guterres, Stela Mari Kuze Rates, Iñaki Trocóniz and Teresa Dalla Costa

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 49-58; DOI: https://doi.org/10.1124/jpet.120.000109
Open Access
Delayed Adjunctive Treatment of Organophosphate-Induced Status Epilepticus in Rats with Phenobarbital, Memantine, or Dexmedetomidine
Jay Spampanato, Steven L. Bealer, Melissa Smolik and F. Edward Dudek

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 59-68; DOI: https://doi.org/10.1124/jpet.120.000175

Endocrine and Diabetes

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Dextromethorphan and Dextrorphan Influence Insulin Secretion by Interacting with K_ATP and L-type Ca²⁺ Channels in Pancreatic β-Cells
Anne Gresch and Martina Düfer

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 10-20; DOI: https://doi.org/10.1124/jpet.120.265835

Gastrointestinal, Hepatic, Pulmonary, and Renal

Open Access
The GPR40 Full Agonist SCO-267 Improves Liver Parameters in a Mouse Model of Nonalcoholic Fatty Liver Disease without Affecting Glucose or Body Weight
Mitsugi Ookawara, Keisuke Matsuda, Masanori Watanabe and Yusuke Moritoh

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 21-27; DOI: https://doi.org/10.1124/jpet.120.000046
Open Access
Gender-Related Differences of Tachykinin NK₂ Receptor Expression and Activity in Human Colonic Smooth Muscle
Stelina Drimousis, Irit Markus, Tim V. Murphy, D. Shevy Perera, Kim-Chi Phan-Thien, Li Zhang and Lu Liu

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 28-39; DOI: https://doi.org/10.1124/jpet.120.265967
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Renal Effects of Dapagliflozin in People with and without Diabetes with Moderate or Severe Renal Dysfunction: Prospective Modeling of an Ongoing Clinical Trial
K. Melissa Hallow, David W. Boulton, Robert C. Penland, Gabriel Helmlinger, Emily H. Nieves, Daniël H. van Raalte, Hiddo L. Heerspink and Peter J. Greasley

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 76-91; DOI: https://doi.org/10.1124/jpet.120.000040
Open Access
Potent Therapy and Transcriptional Profile of Combined Erythropoietin-Derived Peptide Cyclic Helix B Surface Peptide and Caspase-3 siRNA against Kidney Ischemia/Reperfusion Injury in Mice
Yuanyuan Wu, Weiwei Chen, Yufang Zhang, Aifen Liu, Cheng Yang, Hui Wang, Tongyu Zhu, Yaping Fan and Bin Yang

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 92-103; DOI: https://doi.org/10.1124/jpet.120.000092

Metabolism, Transport, and Pharmacogenetics

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Absence of OATP1B (Organic Anion–Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression
Yueping Zhang, Cliff Chen, Shen-Jue Chen, Xue-Qing Chen, David J. Shuster, Pawel D. Puszczalo, R. Marcus Fancher, Zheng Yang, Michael Sinz and Hong Shen

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 139-151; DOI: https://doi.org/10.1124/jpet.120.000139

Toxicology

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Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supralethal Dose of Soman in Cynomolgus Monkeys Posttreated with Conventional Antidotes
Malcolm Lane, D’Arice Carter, Joseph D. Pescrille, Yasco Aracava, William P. Fawcett, G. William Basinger, Edna F.R. Pereira and Edson X. Albuquerque

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 115-126; DOI: https://doi.org/10.1124/jpet.120.265843

Errata

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Correction to “The GPR40 Full Agonist SCO-267 Improves Liver Parameters in a Mouse Model of Nonalcoholic Fatty Liver Disease without Affecting Glucose or Body Weight”
Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 237; DOI: https://doi.org/10.1124/jpet.120.000046err
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Correction to “Translational Pharmacokinetic-Pharmacodynamic Modeling for an Orally Available Novel Inhibitor of Epigenetic Regulator Enhancer of Zeste Homolog 2”
Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 238; DOI: https://doi.org/10.1124/jpet.119.263491err

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Table of Contents

Special Section on Sexual Dimorphism in Neuroimmune Cells

Minireview

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Metabolism, Transport, and Pharmacogenetics

Toxicology

Errata

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