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Research ArticleInflammation, Immunopharmacology, and Asthma

Topical Application of ASN008, a Permanently Charged Sodium Channel Blocker, Shows Robust Efficacy, a Rapid Onset, and Long Duration of Action in a Mouse Model of Pruritus

Roshni Ramachandran, Scott K. Thompson, Shelle Malkmus, Tsutomu Mieda, Jun-Hsiang Lin, Sandeep Gupta and Tony L. Yaksh
Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 521-528; DOI: https://doi.org/10.1124/jpet.120.265074
Roshni Ramachandran
Department of Anesthesiology, University of California, San Diego, California (R.R., S.M., T.M., T.L.Y.) and Asana BioSciences, Lawrenceville, New Jersey (S.K.T., J.-H.L., S.G.)
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Scott K. Thompson
Department of Anesthesiology, University of California, San Diego, California (R.R., S.M., T.M., T.L.Y.) and Asana BioSciences, Lawrenceville, New Jersey (S.K.T., J.-H.L., S.G.)
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Shelle Malkmus
Department of Anesthesiology, University of California, San Diego, California (R.R., S.M., T.M., T.L.Y.) and Asana BioSciences, Lawrenceville, New Jersey (S.K.T., J.-H.L., S.G.)
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Tsutomu Mieda
Department of Anesthesiology, University of California, San Diego, California (R.R., S.M., T.M., T.L.Y.) and Asana BioSciences, Lawrenceville, New Jersey (S.K.T., J.-H.L., S.G.)
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Jun-Hsiang Lin
Department of Anesthesiology, University of California, San Diego, California (R.R., S.M., T.M., T.L.Y.) and Asana BioSciences, Lawrenceville, New Jersey (S.K.T., J.-H.L., S.G.)
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Sandeep Gupta
Department of Anesthesiology, University of California, San Diego, California (R.R., S.M., T.M., T.L.Y.) and Asana BioSciences, Lawrenceville, New Jersey (S.K.T., J.-H.L., S.G.)
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Tony L. Yaksh
Department of Anesthesiology, University of California, San Diego, California (R.R., S.M., T.M., T.L.Y.) and Asana BioSciences, Lawrenceville, New Jersey (S.K.T., J.-H.L., S.G.)
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Article Information

vol. 374 no. 3 521-528
DOI 
https://doi.org/10.1124/jpet.120.265074
PubMed 
32616515

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received January 23, 2020
  • Accepted June 22, 2020
  • Published online August 26, 2020.

Article Versions

  • Earlier version (July 2, 2020 - 06:28).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Roshni Ramachandran,
  2. Scott K. Thompson,
  3. Shelle Malkmus,
  4. Tsutomu Mieda,
  5. Jun-Hsiang Lin,
  6. Sandeep Gupta, and
  7. Tony L. Yaksh
  1. Department of Anesthesiology, University of California, San Diego, California (R.R., S.M., T.M., T.L.Y.) and Asana BioSciences, Lawrenceville, New Jersey (S.K.T., J.-H.L., S.G.)
  1. Address correspondence to:
    Dr. Tony L. Yaksh, Department of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, Mail Code 0818, San Diego, La Jolla, CA 92093-0818. E-mail: tyaksh{at}ucsd.edu
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Journal of Pharmacology and Experimental Therapeutics: 374 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 374, Issue 3
1 Sep 2020
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Research ArticleInflammation, Immunopharmacology, and Asthma

Topical ASN008 and Chemically Induced Itch in a Mouse Model

Roshni Ramachandran, Scott K. Thompson, Shelle Malkmus, Tsutomu Mieda, Jun-Hsiang Lin, Sandeep Gupta and Tony L. Yaksh
Journal of Pharmacology and Experimental Therapeutics September 1, 2020, 374 (3) 521-528; DOI: https://doi.org/10.1124/jpet.120.265074

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Research ArticleInflammation, Immunopharmacology, and Asthma

Topical ASN008 and Chemically Induced Itch in a Mouse Model

Roshni Ramachandran, Scott K. Thompson, Shelle Malkmus, Tsutomu Mieda, Jun-Hsiang Lin, Sandeep Gupta and Tony L. Yaksh
Journal of Pharmacology and Experimental Therapeutics September 1, 2020, 374 (3) 521-528; DOI: https://doi.org/10.1124/jpet.120.265074
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