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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

September 01, 2020; Volume 374,Issue 3

Behavioral Pharmacology

  • The Rewarding and Anxiolytic Properties of Ethanol within the Central Nucleus of the Amygdala: Mediated by Genetic Background and Nociceptin
    You have access
    The Rewarding and Anxiolytic Properties of Ethanol within the Central Nucleus of the Amygdala: Mediated by Genetic Background and Nociceptin
    Christopher P. Knight, Sheketha R. Hauser, R. Aaron Waeiss, Andrei I. Molosh, Philip L. Johnson, William A. Truitt, William J. McBride, Richard L. Bell, Anantha Shekhar and Zachary A. Rodd
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 366-375; DOI: https://doi.org/10.1124/jpet.119.262097
  • You have access
    Antiemetic Effects of Cannabinoid Agonists in Nonhuman Primates
    Lisa M. Wooldridge, Lipin Ji, Yingpeng Liu, Spyros P. Nikas, Alexandros Makriyannis, Jack Bergman and Brian D. Kangas
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 462-468; DOI: https://doi.org/10.1124/jpet.120.265710

Cardiovascular

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    Characterization of Stressed Transgenic Mice Overexpressing H2-Histamine Receptors in the Heart
    Ulrich Gergs, Uwe Kirchhefer, Fabian Bergmann, Bernhard Künstler, Natascha Mißlinger, Bastian Au, Mareen Mahnkopf, Hartmut Wache and Joachim Neumann
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 479-488; DOI: https://doi.org/10.1124/jpet.120.000063

Cellular and Molecular

  • Open Access
    Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells
    Francesca Forno, Yossi Maatuf, Shatha Boukeileh, Priya Dipta, Mohamed Mahameed, Odai Darawshi, Vitor Ferreira, Patricia Rada, Irma García-Martinez, Einav Gross, Avi Priel, Ángela M. Valverde and Boaz Tirosh
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 452-461; DOI: https://doi.org/10.1124/jpet.119.264481
  • You have access
    CD13 Induces Autophagy to Promote Hepatocellular Carcinoma Cell Chemoresistance Through the P38/Hsp27/CREB/ATG7 Pathway
    Yan Zhao, Huina Wu, Xiaoyan Xing, Yuqian Ma, Shengping Ji, Xinyue Xu, Xin Zhao, Sensen Wang, Wenyan Jiang, Chunyan Fang, Lei Zhang, Fang Yan and Xuejian Wang
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 512-520; DOI: https://doi.org/10.1124/jpet.120.265637

Drug Discovery and Translational Medicine

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    Dual-Modified Liposome for Targeted and Enhanced Gene Delivery into Mice Brain
    Bruna dos Santos Rodrigues, Sushant Lakkadwala, Takahisa Kanekiyo and Jagdish Singh
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 354-365; DOI: https://doi.org/10.1124/jpet.119.264127
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    Combining a Candidate Vaccine for Opioid Use Disorders with Extended-Release Naltrexone Increases Protection against Oxycodone-Induced Behavioral Effects and Toxicity
    Michael D. Raleigh, Claudia Accetturo and Marco Pravetoni
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 392-403; DOI: https://doi.org/10.1124/jpet.120.000014
  • (3<em>S</em>)‐3‐(2,3‐difluorophenyl)‐3‐methoxypyrrolidine (IRL752) —a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent
    Open Access
    (3S)‐3‐(2,3‐difluorophenyl)‐3‐methoxypyrrolidine (IRL752) —a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent
    S. Hjorth, S. Waters, N. Waters, J. Tedroff, P. Svensson, A. Fagerberg, M. Edling, B. Svanberg, E. Ljung, J. Gunnergren, S.L. McLean, B. Grayson, N.F. Idris, J.C. Neill and C. Sonesson
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 404-419; DOI: https://doi.org/10.1124/jpet.120.000037
  • Slow-, Tight-Binding Inhibition of CYP17A1 by Abiraterone Redefines Its Kinetic Selectivity and Dosing Regimen
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    Slow-, Tight-Binding Inhibition of CYP17A1 by Abiraterone Redefines Its Kinetic Selectivity and Dosing Regimen
    Eleanor Jing Yi Cheong, Pramod C. Nair, Rebecca Wan Yi Neo, Ho Thanh Tu, Fu Lin, Edmund Chiong, Kesavan Esuvaranathan, Hao Fan, Russell Z. Szmulewitz, Cody J. Peer, William D. Figg, Christina Li Lin Chai, John O. Miners and Eric Chun Yong Chan
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 438-451; DOI: https://doi.org/10.1124/jpet.120.265868
  • Open Access
    Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies
    W.A. Ferreira, H. Chweih, C. Lanaro, C.B. Almeida, P.L. Brito, E.M.F. Gotardo, L. Torres, L.I. Miguel, C.F. Franco-Penteado, F.C. Leonardo, F. Garcia, S.T.O. Saad, P.S. Frenette, D. Brockschnieder, F.F. Costa, J.P. Stasch, P. Sandner and N. Conran
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 469-478; DOI: https://doi.org/10.1124/jpet.119.264606
  • p38<em>α</em> Regulates Expression of DUX4 in a Model of Facioscapulohumeral Muscular Dystrophy
    Open Access
    p38α Regulates Expression of DUX4 in a Model of Facioscapulohumeral Muscular Dystrophy
    L. Alejandro Rojas, Erin Valentine, Anthony Accorsi, Joseph Maglio, Ning Shen, Alan Robertson, Steven Kazmirski, Peter Rahl, Rabi Tawil, Diego Cadavid, Lorin A. Thompson, Lucienne Ronco, Aaron N. Chang, Angela M. Cacace and Owen Wallace
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 489-498; DOI: https://doi.org/10.1124/jpet.119.264689
  • Open Access
    Cell-Based No-Wash Fluorescence Assays for Compound Screens Using a Fluorescence Cytometry Plate Reader
    Kirill Gorshkov, Manisha Pradhan, Miao Xu, Shu Yang, Emily M. Lee, Catherine Z. Chen, Min Shen and Wei Zheng
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 500-511; DOI: https://doi.org/10.1124/jpet.120.265207

Gastrointestinal, Hepatic, Pulmonary, and Renal

  • Therapeutic Effects of Anti-Inflammatory <em>N</em>-Acylhydrazones in the Resolution of Experimental Colitis
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    Therapeutic Effects of Anti-Inflammatory N-Acylhydrazones in the Resolution of Experimental Colitis
    Natália Cordeiro, Rosana Helena Coimbra Nogueira Freitas, Carlos Alberto Manssour Fraga and Patricia Dias Fernandes
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 420-427; DOI: https://doi.org/10.1124/jpet.120.000074
  • You have access
    Renoprotective Effects of a Novel Receptor-Interacting Protein Kinase 2 Inhibitor, AS3334034, in Uninephrectomized Adriamycin-Induced Chronic Kidney Disease Rats
    Yusuke Wada, Mitsuhiro Kondo, Kumi Sakairi, Akira Nagashima, Kenichi Tokita, Hiroaki Tominaga, Hiroshi Tomiyama and Tomohisa Ishikawa
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 428-437; DOI: https://doi.org/10.1124/jpet.120.265678

Inflammation, Immunopharmacology, and Asthma

  • You have access
    Topical Application of ASN008, a Permanently Charged Sodium Channel Blocker, Shows Robust Efficacy, a Rapid Onset, and Long Duration of Action in a Mouse Model of Pruritus
    Roshni Ramachandran, Scott K. Thompson, Shelle Malkmus, Tsutomu Mieda, Jun-Hsiang Lin, Sandeep Gupta and Tony L. Yaksh
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 521-528; DOI: https://doi.org/10.1124/jpet.120.265074

Neuropharmacology

  • You have access
    Fentanyl but not Morphine Interacts with Nonopioid Recombinant Human Neurotransmitter Receptors and Transporters
    Randy Torralva, Amy J. Eshleman, Tracy L. Swanson, Jennifer L. Schmachtenberg, William E. Schutzer, Shelley H. Bloom, Katherine M. Wolfrum, John F. Reed and Aaron Janowsky
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 376-391; DOI: https://doi.org/10.1124/jpet.120.265561

Errata

  • You have access
    Correction to “Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222”
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 499; DOI: https://doi.org/10.1124/jpet.119.261800err
  • You have access
    Correction to “Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells”
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 529; DOI: https://doi.org/10.1124/jpet.119.264481err
  • You have access
    Correction to “A Mechanistic and Translational Pharmacokinetic-Pharmacodynamic Model of Abicipar Pegol and Vascular Endothelial Growth Factor Inhibition”
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 530; DOI: https://doi.org/10.1124/jpet.120.000210
  • You have access
    Correction to “(3S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752) – a Novel Cortical-Preferring Catecholamine Transmission – and Cognition-Promoting Agent”
    Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 531-532; DOI: https://doi.org/10.1124/jpet.120.000304
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 374 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 374, Issue 3
1 Sep 2020
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
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  • Behavioral Pharmacology
  • Cardiovascular
  • Cellular and Molecular
  • Drug Discovery and Translational Medicine
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Neuropharmacology
  • Errata
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  • Potential Clinical Uses of CBG
  • Ocular Drug Delivery: Past, Present, and Future
  • Nose-to-Brain Delivery
  • Antipsychotic-VMAT2 Inhibitor Synergy: Schizophrenia Models
  • SEP-363856, a Novel, Non-D2 Psychotropic Agent
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