Journal of Pharmacology and Experimental Therapeutics: 374 (3)

September 01, 2020; Volume 374,Issue 3

Behavioral Pharmacology

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The Rewarding and Anxiolytic Properties of Ethanol within the Central Nucleus of the Amygdala: Mediated by Genetic Background and Nociceptin
Christopher P. Knight, Sheketha R. Hauser, R. Aaron Waeiss, Andrei I. Molosh, Philip L. Johnson, William A. Truitt, William J. McBride, Richard L. Bell, Anantha Shekhar and Zachary A. Rodd

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 366-375; DOI: https://doi.org/10.1124/jpet.119.262097
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Antiemetic Effects of Cannabinoid Agonists in Nonhuman Primates
Lisa M. Wooldridge, Lipin Ji, Yingpeng Liu, Spyros P. Nikas, Alexandros Makriyannis, Jack Bergman and Brian D. Kangas

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 462-468; DOI: https://doi.org/10.1124/jpet.120.265710

Cardiovascular

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Characterization of Stressed Transgenic Mice Overexpressing H₂-Histamine Receptors in the Heart
Ulrich Gergs, Uwe Kirchhefer, Fabian Bergmann, Bernhard Künstler, Natascha Mißlinger, Bastian Au, Mareen Mahnkopf, Hartmut Wache and Joachim Neumann

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 479-488; DOI: https://doi.org/10.1124/jpet.120.000063

Cellular and Molecular

Open Access
Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells
Francesca Forno, Yossi Maatuf, Shatha Boukeileh, Priya Dipta, Mohamed Mahameed, Odai Darawshi, Vitor Ferreira, Patricia Rada, Irma García-Martinez, Einav Gross, Avi Priel, Ángela M. Valverde and Boaz Tirosh

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 452-461; DOI: https://doi.org/10.1124/jpet.119.264481
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CD13 Induces Autophagy to Promote Hepatocellular Carcinoma Cell Chemoresistance Through the P38/Hsp27/CREB/ATG7 Pathway
Yan Zhao, Huina Wu, Xiaoyan Xing, Yuqian Ma, Shengping Ji, Xinyue Xu, Xin Zhao, Sensen Wang, Wenyan Jiang, Chunyan Fang, Lei Zhang, Fang Yan and Xuejian Wang

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 512-520; DOI: https://doi.org/10.1124/jpet.120.265637

Drug Discovery and Translational Medicine

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Dual-Modified Liposome for Targeted and Enhanced Gene Delivery into Mice Brain
Bruna dos Santos Rodrigues, Sushant Lakkadwala, Takahisa Kanekiyo and Jagdish Singh

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 354-365; DOI: https://doi.org/10.1124/jpet.119.264127
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Combining a Candidate Vaccine for Opioid Use Disorders with Extended-Release Naltrexone Increases Protection against Oxycodone-Induced Behavioral Effects and Toxicity
Michael D. Raleigh, Claudia Accetturo and Marco Pravetoni

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 392-403; DOI: https://doi.org/10.1124/jpet.120.000014
Open Access
(3S)‐3‐(2,3‐difluorophenyl)‐3‐methoxypyrrolidine (IRL752) —a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent
S. Hjorth, S. Waters, N. Waters, J. Tedroff, P. Svensson, A. Fagerberg, M. Edling, B. Svanberg, E. Ljung, J. Gunnergren, S.L. McLean, B. Grayson, N.F. Idris, J.C. Neill and C. Sonesson

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 404-419; DOI: https://doi.org/10.1124/jpet.120.000037
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Slow-, Tight-Binding Inhibition of CYP17A1 by Abiraterone Redefines Its Kinetic Selectivity and Dosing Regimen
Eleanor Jing Yi Cheong, Pramod C. Nair, Rebecca Wan Yi Neo, Ho Thanh Tu, Fu Lin, Edmund Chiong, Kesavan Esuvaranathan, Hao Fan, Russell Z. Szmulewitz, Cody J. Peer, William D. Figg, Christina Li Lin Chai, John O. Miners and Eric Chun Yong Chan

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 438-451; DOI: https://doi.org/10.1124/jpet.120.265868
Open Access
Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies
W.A. Ferreira, H. Chweih, C. Lanaro, C.B. Almeida, P.L. Brito, E.M.F. Gotardo, L. Torres, L.I. Miguel, C.F. Franco-Penteado, F.C. Leonardo, F. Garcia, S.T.O. Saad, P.S. Frenette, D. Brockschnieder, F.F. Costa, J.P. Stasch, P. Sandner and N. Conran

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 469-478; DOI: https://doi.org/10.1124/jpet.119.264606
Open Access
p38α Regulates Expression of DUX4 in a Model of Facioscapulohumeral Muscular Dystrophy
L. Alejandro Rojas, Erin Valentine, Anthony Accorsi, Joseph Maglio, Ning Shen, Alan Robertson, Steven Kazmirski, Peter Rahl, Rabi Tawil, Diego Cadavid, Lorin A. Thompson, Lucienne Ronco, Aaron N. Chang, Angela M. Cacace and Owen Wallace

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 489-498; DOI: https://doi.org/10.1124/jpet.119.264689
Open Access
Cell-Based No-Wash Fluorescence Assays for Compound Screens Using a Fluorescence Cytometry Plate Reader
Kirill Gorshkov, Manisha Pradhan, Miao Xu, Shu Yang, Emily M. Lee, Catherine Z. Chen, Min Shen and Wei Zheng

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 500-511; DOI: https://doi.org/10.1124/jpet.120.265207

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Therapeutic Effects of Anti-Inflammatory N-Acylhydrazones in the Resolution of Experimental Colitis
Natália Cordeiro, Rosana Helena Coimbra Nogueira Freitas, Carlos Alberto Manssour Fraga and Patricia Dias Fernandes

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 420-427; DOI: https://doi.org/10.1124/jpet.120.000074
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Renoprotective Effects of a Novel Receptor-Interacting Protein Kinase 2 Inhibitor, AS3334034, in Uninephrectomized Adriamycin-Induced Chronic Kidney Disease Rats
Yusuke Wada, Mitsuhiro Kondo, Kumi Sakairi, Akira Nagashima, Kenichi Tokita, Hiroaki Tominaga, Hiroshi Tomiyama and Tomohisa Ishikawa

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 428-437; DOI: https://doi.org/10.1124/jpet.120.265678

Inflammation, Immunopharmacology, and Asthma

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Topical Application of ASN008, a Permanently Charged Sodium Channel Blocker, Shows Robust Efficacy, a Rapid Onset, and Long Duration of Action in a Mouse Model of Pruritus
Roshni Ramachandran, Scott K. Thompson, Shelle Malkmus, Tsutomu Mieda, Jun-Hsiang Lin, Sandeep Gupta and Tony L. Yaksh

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 521-528; DOI: https://doi.org/10.1124/jpet.120.265074

Neuropharmacology

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Fentanyl but not Morphine Interacts with Nonopioid Recombinant Human Neurotransmitter Receptors and Transporters
Randy Torralva, Amy J. Eshleman, Tracy L. Swanson, Jennifer L. Schmachtenberg, William E. Schutzer, Shelley H. Bloom, Katherine M. Wolfrum, John F. Reed and Aaron Janowsky

Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 376-391; DOI: https://doi.org/10.1124/jpet.120.265561

Errata

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Correction to “Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222”
Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 499; DOI: https://doi.org/10.1124/jpet.119.261800err
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Correction to “Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells”
Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 529; DOI: https://doi.org/10.1124/jpet.119.264481err
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Correction to “A Mechanistic and Translational Pharmacokinetic-Pharmacodynamic Model of Abicipar Pegol and Vascular Endothelial Growth Factor Inhibition”
Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 530; DOI: https://doi.org/10.1124/jpet.120.000210
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Correction to “(3S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752) – a Novel Cortical-Preferring Catecholamine Transmission – and Cognition-Promoting Agent”
Journal of Pharmacology and Experimental Therapeutics September 2020, 374 (3) 531-532; DOI: https://doi.org/10.1124/jpet.120.000304

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Table of Contents

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Neuropharmacology

Errata

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