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Research ArticleNeuropharmacology
Open Access

Use of a Noninvasive Brain-Penetrating Peptide-Drug Conjugate Strategy to Improve the Delivery of Opioid Pain Relief Medications to the Brain

Émilie Eiselt, Valérie Otis, Karine Belleville, Gaoqiang Yang, Alain Larocque, Anthony Régina, Michel Demeule, Philippe Sarret and Louis Gendron
Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 52-61; DOI: https://doi.org/10.1124/jpet.119.263566
Émilie Eiselt
Département de pharmacologie-physiologie, Institut de pharmacologie de Sherbrooke, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada (É.E., V.O., K.B., P.S., L.G.); Angiochem Inc., Montréal, Québec, Canada (G.Y., A.L., A.R., M.D.); and Quebec Pain Research Network, Sherbrooke, Québec, Canada (P.S., L.G.)
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Valérie Otis
Département de pharmacologie-physiologie, Institut de pharmacologie de Sherbrooke, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada (É.E., V.O., K.B., P.S., L.G.); Angiochem Inc., Montréal, Québec, Canada (G.Y., A.L., A.R., M.D.); and Quebec Pain Research Network, Sherbrooke, Québec, Canada (P.S., L.G.)
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Karine Belleville
Département de pharmacologie-physiologie, Institut de pharmacologie de Sherbrooke, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada (É.E., V.O., K.B., P.S., L.G.); Angiochem Inc., Montréal, Québec, Canada (G.Y., A.L., A.R., M.D.); and Quebec Pain Research Network, Sherbrooke, Québec, Canada (P.S., L.G.)
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Gaoqiang Yang
Département de pharmacologie-physiologie, Institut de pharmacologie de Sherbrooke, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada (É.E., V.O., K.B., P.S., L.G.); Angiochem Inc., Montréal, Québec, Canada (G.Y., A.L., A.R., M.D.); and Quebec Pain Research Network, Sherbrooke, Québec, Canada (P.S., L.G.)
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Alain Larocque
Département de pharmacologie-physiologie, Institut de pharmacologie de Sherbrooke, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada (É.E., V.O., K.B., P.S., L.G.); Angiochem Inc., Montréal, Québec, Canada (G.Y., A.L., A.R., M.D.); and Quebec Pain Research Network, Sherbrooke, Québec, Canada (P.S., L.G.)
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Anthony Régina
Département de pharmacologie-physiologie, Institut de pharmacologie de Sherbrooke, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada (É.E., V.O., K.B., P.S., L.G.); Angiochem Inc., Montréal, Québec, Canada (G.Y., A.L., A.R., M.D.); and Quebec Pain Research Network, Sherbrooke, Québec, Canada (P.S., L.G.)
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Michel Demeule
Département de pharmacologie-physiologie, Institut de pharmacologie de Sherbrooke, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada (É.E., V.O., K.B., P.S., L.G.); Angiochem Inc., Montréal, Québec, Canada (G.Y., A.L., A.R., M.D.); and Quebec Pain Research Network, Sherbrooke, Québec, Canada (P.S., L.G.)
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Philippe Sarret
Département de pharmacologie-physiologie, Institut de pharmacologie de Sherbrooke, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada (É.E., V.O., K.B., P.S., L.G.); Angiochem Inc., Montréal, Québec, Canada (G.Y., A.L., A.R., M.D.); and Quebec Pain Research Network, Sherbrooke, Québec, Canada (P.S., L.G.)
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  • For correspondence: Philippe.Sarret@USherbrooke.ca
Louis Gendron
Département de pharmacologie-physiologie, Institut de pharmacologie de Sherbrooke, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada (É.E., V.O., K.B., P.S., L.G.); Angiochem Inc., Montréal, Québec, Canada (G.Y., A.L., A.R., M.D.); and Quebec Pain Research Network, Sherbrooke, Québec, Canada (P.S., L.G.)
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  • For correspondence: Louis.Gendron@USherbrooke.ca
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Article Information

vol. 374 no. 1 52-61
DOI 
https://doi.org/10.1124/jpet.119.263566
PubMed 
32327529

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received November 3, 2019
  • Published online June 10, 2020.

Article Versions

  • Earlier version (April 23, 2020 - 08:59).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2020 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. Émilie Eiselt,
  2. Valérie Otis,
  3. Karine Belleville,
  4. Gaoqiang Yang,
  5. Alain Larocque,
  6. Anthony Régina,
  7. Michel Demeule,
  8. Philippe Sarret⇑, and
  9. Louis Gendron⇑
  1. Département de pharmacologie-physiologie, Institut de pharmacologie de Sherbrooke, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada (É.E., V.O., K.B., P.S., L.G.); Angiochem Inc., Montréal, Québec, Canada (G.Y., A.L., A.R., M.D.); and Quebec Pain Research Network, Sherbrooke, Québec, Canada (P.S., L.G.)
  1. Address correspondence to:
    Dr. Louis Gendron, Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Ave North, Sherbrooke, QC J1H 5N4, Canada. E-mail: Louis.Gendron{at}USherbrooke.ca; or
  2. Dr. Philippe Sarret, Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Ave North, Sherbrooke, QC J1H 5N4, Canada. E-mail: Philippe.Sarret{at}USherbrooke.ca
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Journal of Pharmacology and Experimental Therapeutics: 374 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 374, Issue 1
1 Jul 2020
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Research ArticleNeuropharmacology

An2-Morphine and An2-M6G Conjugates as Potent Analgesics

Émilie Eiselt, Valérie Otis, Karine Belleville, Gaoqiang Yang, Alain Larocque, Anthony Régina, Michel Demeule, Philippe Sarret and Louis Gendron
Journal of Pharmacology and Experimental Therapeutics July 1, 2020, 374 (1) 52-61; DOI: https://doi.org/10.1124/jpet.119.263566

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Research ArticleNeuropharmacology

An2-Morphine and An2-M6G Conjugates as Potent Analgesics

Émilie Eiselt, Valérie Otis, Karine Belleville, Gaoqiang Yang, Alain Larocque, Anthony Régina, Michel Demeule, Philippe Sarret and Louis Gendron
Journal of Pharmacology and Experimental Therapeutics July 1, 2020, 374 (1) 52-61; DOI: https://doi.org/10.1124/jpet.119.263566
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