Journal of Pharmacology and Experimental Therapeutics: 374 (1)

July 01, 2020; Volume 374,Issue 1

Minireview

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Analgesia with Gabapentin and Pregabalin May Involve N-Methyl-d-Aspartate Receptors, Neurexins, and Thrombospondins
Charles P. Taylor and Eric W. Harris

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 161-174; DOI: https://doi.org/10.1124/jpet.120.266056

Behavioral Pharmacology

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Evaluation of the Reinforcing Strength of Phendimetrazine Using a Progressive-Ratio Schedule of Reinforcement in Rhesus Monkeys
Molly Minkiewicz, Paul W. Czoty, Bruce E. Blough and Michael A. Nader

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 1-5; DOI: https://doi.org/10.1124/jpet.120.264952
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The Effects of Eating a High Fat Diet on Sensitivity of Male and Female Rats to Methamphetamine and Dopamine D₁ Receptor Agonist SKF 82958
Jeremiah Ramos, Ethan J. Hardin, Alice H. Grant, Grace Flores-Robles, Adrian T. Gonzalez, Bryan Cruz, Arantxa K. Martinez, Nina M. Beltran and Katherine M. Serafine

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 6-15; DOI: https://doi.org/10.1124/jpet.119.263293
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Extending the Specificity of DRL 72-s Behavior for Screening Antidepressant-Like Effects of Glutamatergic Clinically Validated Anxiolytic or Antidepressant Drugs in Rats
Gerard J. Marek and Allyson A. Salek

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 200-210; DOI: https://doi.org/10.1124/jpet.119.264069

Cellular and Molecular

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7α,25-Dihydroxycholesterol Suppresses Hepatocellular Steatosis through GPR183/EBI2 in Mouse and Human Hepatocytes
Jin Huang, Seung-Jin Lee, Saeromi Kang, Man Ho Choi and Dong-Soon Im

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 142-150; DOI: https://doi.org/10.1124/jpet.120.264960

Chemotherapy, Antibiotics, and Gene Therapy

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Inhibition of Mitogen-Activated Protein Kinase Kinase Alone and in Combination with Anaplastic Lymphoma Kinase (ALK) Inhibition Suppresses Tumor Growth in a Mouse Model of ALK-Positive Lung Cancer
N. Shrestha, A.R. Bland, R.L. Bower, R.J. Rosengren and J.C. Ashton

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 134-140; DOI: https://doi.org/10.1124/jpet.120.266049

Drug Discovery and Translational Medicine

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The Development and Characterization of an scFv-Fc Fusion–Based Gene Therapy to Reduce the Psychostimulant Effects of Methamphetamine Abuse
Charles E. Hay, Laura E. Ewing, Michael D. Hambuchen, Shannon M. Zintner, Juliana C. Small, Chris T. Bolden, William E. Fantegrossi, Paris Margaritis, S. Michael Owens and Eric C. Peterson

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 16-23; DOI: https://doi.org/10.1124/jpet.119.261180
Open Access
Potential Therapeutic Value of Urotensin II Receptor Antagonist in Chronic Kidney Disease and Associated Comorbidities
Marie-Laure Ozoux, Véronique Briand, Michel Pelat, Fabrice Barbe, Paul Schaeffer, Philippe Beauverger, Bruno Poirier, Jean-Michel Guillon, Frédéric Petit, Jean-Michel Altenburger, Jean-Pierre Bidouard and Philip Janiak

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 24-37; DOI: https://doi.org/10.1124/jpet.120.265496
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Topical Delivery of Muscarinic Receptor Antagonists Prevents and Reverses Peripheral Neuropathy in Female Diabetic Mice
Corinne G. Jolivalt, Katie E. Frizzi, May Madi Han, Andre J. Mota, Lucie S. Guernsey, Lakshmi P. Kotra, Paul Fernyhough and Nigel A. Calcutt

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 44-51; DOI: https://doi.org/10.1124/jpet.120.265447
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The Calcitonin Receptor Plays a Major Role in Glucose Regulation as a Function of Dual Amylin and Calcitonin Receptor Agonist Therapy
Anna Thorsø Larsen, Nina Sonne, Kim Vietz Andreassen, Morten Asser Karsdal and Kim Henriksen

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 74-83; DOI: https://doi.org/10.1124/jpet.119.263392
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TAS-303 Ameliorates Carbachol-Induced Detrusor Overactivity in Rats, Revealing Its Therapeutic Potential for Overactive Bladder
Hiroya Mizutani, Fukumitsu Sakakibara and Eiji Sasaki

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 84-92; DOI: https://doi.org/10.1124/jpet.119.264572
Open Access
Pharmacologic Characterization of ALD403, a Potent Neutralizing Humanized Monoclonal Antibody Against the Calcitonin Gene-Related Peptide
Leon F. Garcia-Martinez, Carol J. Raport, Ethan W. Ojala, Benjamin Dutzar, Katie Anderson, Erica Stewart, Brian Kovacevich, Brian Baker, Jens Billgren, Michelle Scalley-Kim, Charlie Karasek, Dan Allison and John A. Latham

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 93-103; DOI: https://doi.org/10.1124/jpet.119.264671
Open Access
Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease
Susanna Waters, Clas Sonesson, Peder Svensson, Joakim Tedroff, Manolo Carta, Elisabeth Ljung, Jenny Gunnergren, Malin Edling, Boel Svanberg, Anne Fagerberg, Johan Kullingsjö, Stephan Hjorth and Nicholas Waters

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 113-125; DOI: https://doi.org/10.1124/jpet.119.264226
Open Access
Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy
Niu Shin, Matthew Stubbs, Holly Koblish, Eddy W. Yue, Maxim Soloviev, Brent Douty, Kathy He Wang, Qian Wang, Mingming Gao, Patricia Feldman, Gengjie Yang, Leslie Hall, Michael Hansbury, Sybil O’Connor, Lynn Leffet, Robert Collins, Kamna Katiyar, Xin He, Paul Waeltz, Paul Collier, Jin Lu, Yun-Long Li, Yanlong Li, Phillip C.C. Liu, Timothy Burn, Maryanne Covington, Sharon Diamond, Dana Shuey, Alan Roberts, Swamy Yeleswaram, Greg Hollis, Brian Metcalf, Wenqing Yao, Reid Huber, Andrew Combs, Robert Newton and Peggy Scherle

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 211-222; DOI: https://doi.org/10.1124/jpet.120.265538

Inflammation, Immunopharmacology, and Asthma

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Pharmacological Screening Identifies SHK242 and SHK277 as Novel Arginase Inhibitors with Efficacy against Allergen-Induced Airway Narrowing In Vitro and In Vivo
M.P.M. van den Berg, S.H. Kurhade, H. Maarsingh, S. Erceg, I.R. Hulsbeek, P.H. Boekema, L.E.M. Kistemaker, M. van Faassen, I.P. Kema, P.H. Elsinga, A. Dömling, H. Meurs and R. Gosens

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 62-73; DOI: https://doi.org/10.1124/jpet.119.264341
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Fluvastatin Induces Apoptosis in Primary and Transformed Mast Cells
Patrick A. Paez, Motunrayo Kolawole, Marcela T. Taruselli, Siddarth Ajith, Jordan M. Dailey, Sydney A. Kee, Tamara T. Haque, Brian O. Barnstein, Jamie Josephine Avila McLeod, Heather L. Caslin, Kasalina N. Kiwanuka, Yoshihiro Fukuoka, Quang T. Le, Lawrence B. Schwartz, David B. Straus, David A. Gewirtz, Rebecca K. Martin and John J. Ryan

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 104-112; DOI: https://doi.org/10.1124/jpet.119.264234

Metabolism, Transport, and Pharmacogenomics

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ABCG2 Deficiency Does Not Alter Dolutegravir Metabolism and Pharmacokinetics
Junjie Zhu, Xin Tian, Amina I. Shehu, Deborah K. McMahon and Xiaochao Ma

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 38-43; DOI: https://doi.org/10.1124/jpet.119.264424
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Ezetimibe Markedly Reduces Hepatic Triglycerides and Cholesterol in Rats Fed on Fish Oil by Increasing the Expression of Cholesterol Efflux Transporters
Yuji Tanaka, Takanori Ikeda, Hiroshi Ogawa and Toshinori Kamisako

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 175-183; DOI: https://doi.org/10.1124/jpet.120.265660
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Evolution of the Systems Pharmacokinetics-Pharmacodynamics Model for Antibody-Drug Conjugates to Characterize Tumor Heterogeneity and In Vivo Bystander Effect
Aman P. Singh, Gail M. Seigel, Leiming Guo, Ashwni Verma, Gloria Gao-Li Wong, Hsuan-Ping Cheng and Dhaval K. Shah

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 184-199; DOI: https://doi.org/10.1124/jpet.119.262287
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Simultaneous Target-Mediated Drug Disposition Model for Two Small-Molecule Compounds Competing for Their Pharmacological Target: Soluble Epoxide Hydrolase
Nan Wu, Bruce D. Hammock, Kin Sing Stephen Lee and Guohua An

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 223-232; DOI: https://doi.org/10.1124/jpet.120.265330

Neuropharmacology

Open Access
Use of a Noninvasive Brain-Penetrating Peptide-Drug Conjugate Strategy to Improve the Delivery of Opioid Pain Relief Medications to the Brain
Émilie Eiselt, Valérie Otis, Karine Belleville, Gaoqiang Yang, Alain Larocque, Anthony Régina, Michel Demeule, Philippe Sarret and Louis Gendron

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 52-61; DOI: https://doi.org/10.1124/jpet.119.263566
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Effects of a Novel Psychomotor Stabilizer, IRL790, on Biochemical Measures of Synaptic Markers and Neurotransmission
Kristina Becanovic, Maria Vittoria de Donno, Vasco C. Sousa, Joakim Tedroff and Per Svenningsson

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 126-133; DOI: https://doi.org/10.1124/jpet.119.264754
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Comparative Pharmacokinetics of Δ⁹-Tetrahydrocannabinol in Adolescent and Adult Male Mice
Alexa Torrens, Valentina Vozella, Hannah Huff, Brandon McNeil, Faizy Ahmed, Andrea Ghidini, Stephen V. Mahler, Marilyn A. Huestis, Aditi Das and Daniele Piomelli

Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 151-160; DOI: https://doi.org/10.1124/jpet.120.265892

Erratum

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Correction to “Menaquinone-4 Accelerates Calcification of Human Aortic Valve Interstitial Cells in High-Phosphate Medium through PXR”
Journal of Pharmacology and Experimental Therapeutics July 2020, 374 (1) 141; DOI: https://doi.org/10.1124/jpet.119.263160err

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Table of Contents

Minireview

Behavioral Pharmacology

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

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