Journal of Pharmacology and Experimental Therapeutics: 373 (3)

June 01, 2020; Volume 373,Issue 3

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Cytokines and Growth Factors as Predictors of Response to Medical Treatment in Diabetic Macular Edema
Sónia Torres-Costa, Maria Carolina Alves Valente, Fernando Falcão-Reis and Manuel Falcão

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 445-452; DOI: https://doi.org/10.1124/jpet.119.262956

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Antinociceptive and Immune Effects of Delta-9-Tetrahydrocannabinol or Cannabidiol in Male Versus Female Rats with Persistent Inflammatory Pain
Stevie C. Britch, Alan G. Goodman, Jenny L. Wiley, Abby M. Pondelick and Rebecca M. Craft

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 416-428; DOI: https://doi.org/10.1124/jpet.119.263319

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Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase IIβ Interaction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity
Petra Kollárová-Brázdová, Anna Jirkovská, Galina Karabanovich, Zuzana Pokorná, Hana Bavlovič Piskáčková, Eduard Jirkovský, Jan Kubeš, Olga Lenčová-Popelová, Yvona Mazurová, Michaela Adamcová, Veronika Skalická, Petra Štěrbová-Kovaříková, Jaroslav Roh, Tomáš Šimůnek and Martin Štěrba

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 402-415; DOI: https://doi.org/10.1124/jpet.119.264580
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Adrenoceptor Responses in Human Embryonic Stem Cell–Derived Cardiomyocytes: a Special Focus on Electrophysiological Property
Weiwei Jiang, Xingjian Hu, Fei Li, Geng Li and Yin Wang

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 429-437; DOI: https://doi.org/10.1124/jpet.120.265686
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eNOS-Nitric Oxide System Contributes to a Novel Antiatherogenic Effect of Leonurine via Inflammation Inhibition and Plaque Stabilization
Ke Ning, Ming-Jie Wang, Ge Lin, Yi-Lin Zhang, Meng-Yao Li, Bao-Feng Yang, Ying Chen, Yong Huang, Zhi-Ming Li, Yi-Jun Huang, Lei Zhu, Kun Liang, Bo Yu, Yi-Zhun Zhu and Yi-Chun Zhu

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 463-475; DOI: https://doi.org/10.1124/jpet.119.264887

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Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine
Rían W. Manville and Geoffrey W. Abbott

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 391-401; DOI: https://doi.org/10.1124/jpet.119.264507

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Pharmacokinetic-Pharmacodynamic-Efficacy Modeling of ONO-7579, a Novel Pan–Tropomyosin Receptor Kinase Inhibitor, in a Murine Xenograft Tumor Model
Hiroyuki Iida, Ryu Fujikawa, Ryohei Kozaki, Ryuichi Harada, Yuya Hosokawa, Ken-ichi Ogawara and Tomoya Ohno

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 361-369; DOI: https://doi.org/10.1124/jpet.119.264499
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Distribution and Function of Prostaglandin E₂ Receptors in Mouse Uterus: Translational Value for Human Reproduction
Deborah P. Fischer, Anna L. Griffiths, Sylvia Lui, Uzmah J. Sabar, Diane Farrar, Peter J. O’Donovan, David F. Woodward and Kay M. Marshall

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 381-390; DOI: https://doi.org/10.1124/jpet.119.263509

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Site-Specific and Temporal Effects of Apraglutide, a Novel Long-Acting Glucagon-Like Peptide-2 Receptor Agonist, on Intestinal Growth in Mice
S.E. Martchenko, M.E. Sweeney, V. Dimitriadou, J.A. Murray and P.L. Brubaker

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 347-352; DOI: https://doi.org/10.1124/jpet.119.263947
Open Access
Pharmacological Profile of Naldemedine, a Peripherally Acting μ-Opioid Receptor Antagonist: Comparison with Naloxone and Naloxegol
Toshiyuki Kanemasa, Katsumi Koike, Kenji Takase, Tohko Arai, Atsushi Nakamura, Yasuhide Morioka and Minoru Hasegawa

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 438-444; DOI: https://doi.org/10.1124/jpet.119.264515

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Treatment of Allergic Asthma with Fenretinide Formulation (LAU-7b) Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 (Ormdl3) Expression and Normalizes Ceramide Imbalance
Mina Youssef, Juan B. De Sanctis, Juhi Shah, Daciana Catalina Dumut, Marian Hajduch, Anna K. Naumova and Danuta Radzioch

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 476-487; DOI: https://doi.org/10.1124/jpet.119.263715

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Mechanistic PBPK Modeling of Urine pH Effect on Renal and Systemic Disposition of Methamphetamine and Amphetamine
Weize Huang, Lindsay C. Czuba and Nina Isoherranen

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 488-501; DOI: https://doi.org/10.1124/jpet.120.264994

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Development of an In Vivo Method to Estimate Effective Drug Doses and Quantify Fatty Acid Amide Hydrolase in Rodent Brain using Positron Emission Tomography Tracer [¹¹C]DFMC
Tomoteru Yamasaki, Tomoyuki Ohya, Wakana Mori, Yiding Zhang, Hidekatsu Wakizaka, Nobuki Nengaki, Masayuki Fujinaga, Tatsuya Kikuchi and Ming-Rong Zhang

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 353-360; DOI: https://doi.org/10.1124/jpet.119.263772
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Duloxetine Attenuates Paclitaxel-Induced Peripheral Nerve Injury by Inhibiting p53-Related Pathways
Yuting Lu, Peng Zhang, Qiuyan Zhang, Chao Yang, Yangyan Qian, Jinshuai Suo, Xinxia Tao and Jing Zhu

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 453-462; DOI: https://doi.org/10.1124/jpet.120.265082

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Chronic Ethanol Feeding in Mice Decreases Expression of Genes for Major Structural Bone Proteins in a Nox4-Independent Manner
Kim B. Pedersen, Michelle L. Osborn, Alex C. Robertson, Ashlee E. Williams, James Watt, Alexandra Denys, Katrin Schröder and Martin J. Ronis

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 337-346; DOI: https://doi.org/10.1124/jpet.119.264374
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Phosphorylation Modulates the Coregulatory Protein Exchange of the Nuclear Receptor Pregnane X Receptor
Wenqi Cui, Xunan Shen, Emre Agbas, Brandon Tompkins, Hadley Cameron-Carter and Jeff L. Staudinger

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 370-380; DOI: https://doi.org/10.1124/jpet.119.264762