Journal of Pharmacology and Experimental Therapeutics: 373 (2)

May 01, 2020; Volume 373,Issue 2

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Open Access
Glycoconjugation as a Promising Treatment Strategy for Psoriasis
Sebastian Makuch, Marta Woźniak, Monika Krawczyk, Gabriela Pastuch-Gawołek, Wiesław Szeja and Siddarth Agrawal

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 204-212; DOI: https://doi.org/10.1124/jpet.119.263657

Behavioral Pharmacology

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Dose Frequency Optimization of the Dual Amylin and Calcitonin Receptor Agonist KBP-088: Long-Lasting Improvement in Food Preference and Body Weight Loss
Anna Thorsø Larsen, Nina Sonne, Kim V. Andreassen, Morten A. Karsdal and Kim Henriksen

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 269-278; DOI: https://doi.org/10.1124/jpet.119.263400

Cardiovascular

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COMT-Catalyzed Palmitic Acid Methyl Ester Biosynthesis in Perivascular Adipose Tissue and its Potential Role Against Hypertension
Chin-Hung Liu, Hao-Jen Hsu, Tzu-Ling Tseng, Tsung-Jen Lin, Wei-Hsiang Weng, Mei-Fang Chen and Tony Jer-Fu Lee

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 175-183; DOI: https://doi.org/10.1124/jpet.119.263517

Cellular and Molecular

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NO-Releasing Nanoparticles Ameliorate Detrusor Overactivity in Transgenic Sickle Cell Mice via Restored NO/ROCK Signaling
Serkan Karakus, Biljana Musicki, Mahantesh S. Navati, Joel M. Friedman, Kelvin P. Davies and Arthur L. Burnett

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 214-219; DOI: https://doi.org/10.1124/jpet.119.264697
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Distinct Regulation of σ₁ Receptor Multimerization by Its Agonists and Antagonists in Transfected Cells and Rat Liver Membranes
Weimin Conrad Hong

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 290-301; DOI: https://doi.org/10.1124/jpet.119.262790

Drug Discovery and Translational Medicine

Open Access
A Mechanistic and Translational Pharmacokinetic-Pharmacodynamic Model of Abicipar Pegol and Vascular Endothelial Growth Factor Inhibition
Kenneth T. Luu, Jennifer R. Seal and Mayssa Attar

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 184-192; DOI: https://doi.org/10.1124/jpet.119.263178
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Pharmacological Characterization of Apraglutide, a Novel Long-Acting Peptidic Glucagon-Like Peptide-2 Agonist, for the Treatment of Short Bowel Syndrome
Diane M. Hargrove, Sudarkodi Alagarsamy, Glenn Croston, Régent Laporte, Steve Qi, Karthik Srinivasan, Javier Sueiras-Diaz, Kazimierz Wiśniewski, Jennifer Hartwig, Mark Lu, Alexander P. Posch, Halina Wiśniewska, Claudio D. Schteingart, Pierre J.-M. Rivière and Violetta Dimitriadou

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 193-203; DOI: https://doi.org/10.1124/jpet.119.262238
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Translational Pharmacokinetic-Pharmacodynamic Modeling for an Orally Available Novel Inhibitor of Epigenetic Regulator Enhancer of Zeste Homolog 2
Shinji Yamazaki, Hovhannes J. Gukasyan, Hui Wang, Sean Uryu and Shikhar Sharma

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 220-229; DOI: https://doi.org/10.1124/jpet.119.263491
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The Endocannabinoid System Alleviates Pain in a Murine Model of Cancer-Induced Bone Pain
A.L. Thompson, S.A. Grenald, H.A. Ciccone, N. BassiriRad, M.J. Niphakis, B.F. Cravatt, T.M. Largent-Milnes and T.W. Vanderah

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 230-238; DOI: https://doi.org/10.1124/jpet.119.262337
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Inner Ear Arginine Vasopressin-Vasopressin Receptor 2-Aquaporin 2 Signaling Pathway Is Involved in the Induction of Motion Sickness
Li-Hua Xu, Yao Yang, Hong-Xia Liu, Shui-Feng Xiao, Wen-Xia Qiu, Jin-Xing Wang, Chen-Chen Zhao, Yuan-Hong Gui, Gui-Zhu Liu, Bin Peng, Xia Li, Guo-Hua Wang, Xin Zhou and Zheng-Lin Jiang

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 248-260; DOI: https://doi.org/10.1124/jpet.119.264390

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Mouse Colonic Epithelial Cells Functionally Express the Histamine H₄ Receptor
Bastian Schirmer, Luisa Lindemann, Kaya Saskia Bittkau, Rukijat Isaev, Daniela Bösche, Malte Juchem, Roland Seifert and Detlef Neumann

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 167-174; DOI: https://doi.org/10.1124/jpet.119.264408
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KPR-5714, a Novel Transient Receptor Potential Melastatin 8 Antagonist, Improves Overactive Bladder via Inhibition of Bladder Afferent Hyperactivity in Rats
Osamu Nakanishi, Yoshikazu Fujimori, Naoki Aizawa, Takemitsu Hayashi, Akane Matsuzawa, Jun-ichi Kobayashi, Hideaki Hirasawa, Yosuke Mutai, Fumiya Tanada and Yasuhiko Igawa

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 239-247; DOI: https://doi.org/10.1124/jpet.119.263616
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Cordycepin Inhibits Cancer Cell Proliferation and Angiogenesis through a DEK Interaction via ERK Signaling in Cholangiocarcinoma
Tesi Liu, Guang Zhu, Wendi Yan, You Lv, Xue Wang, Guang Jin, Minghua Cui, Zhenhua Lin and Xiangshan Ren

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 279-289; DOI: https://doi.org/10.1124/jpet.119.263202

Inflammation, Immunopharmacology, and Asthma

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Cinnamaldehyde Inhibits Inflammation of Human Synoviocyte Cells Through Regulation of Jak/Stat Pathway and Ameliorates Collagen-Induced Arthritis in Rats
Wen-Xiang Cheng, Shan Zhong, Xiang-Bo Meng, Nian-Ye Zheng, Peng Zhang, Yun Wang, Ling Qin and Xin-Luan Wang

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 302-310; DOI: https://doi.org/10.1124/jpet.119.262907

Metabolism, Transport, and Pharmacogenomics

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Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk
Katsuaki Ito, Noora Sjöstedt, Melina M. Malinen, Cen Guo and Kim L.R. Brouwer

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 261-268; DOI: https://doi.org/10.1124/jpet.119.263459

Neuropharmacology

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Pharmacological Characterization of the Novel and Selective α7 Nicotinic Acetylcholine Receptor–Positive Allosteric Modulator BNC375
Xiaohai Wang, Christopher Daley, Vanita Gakhar, Henry S. Lange, Joshua D. Vardigan, Michelle Pearson, Xiaoping Zhou, Lee Warren, Corin O. Miller, Michelle Belden, Andrew J. Harvey, Anton A. Grishin, Carolyn J. Coles, Susan M. O’Connor, Fiona Thomson, Joseph L. Duffy, Ian M. Bell and Jason M. Uslaner

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 311-324; DOI: https://doi.org/10.1124/jpet.119.263483
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Pre-eclamptic Fetal Programming Alters Neuroinflammatory and Cardiovascular Consequences of Endotoxemia in Sex-Specific Manners
Salwa A. Abuiessa, Abdalla M. Wedn, Sahar M. El-Gowilly, Mai M. Helmy and Mahmoud M. El-Mas

Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 325-336; DOI: https://doi.org/10.1124/jpet.119.264192

Erratum

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Correction to “Probing the Assembly of HDL Mimetic, Drug Carrying Nanoparticles Using Intrinsic Fluorescence”
Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 213; DOI: https://doi.org/10.1124/jpet.119.262899err

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Table of Contents

Minireviews

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Erratum

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