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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

May 01, 2020; Volume 373,Issue 2

Minireviews

  • Open Access
    Glycoconjugation as a Promising Treatment Strategy for Psoriasis
    Sebastian Makuch, Marta Woźniak, Monika Krawczyk, Gabriela Pastuch-Gawołek, Wiesław Szeja and Siddarth Agrawal
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 204-212; DOI: https://doi.org/10.1124/jpet.119.263657

Behavioral Pharmacology

  • You have access
    Dose Frequency Optimization of the Dual Amylin and Calcitonin Receptor Agonist KBP-088: Long-Lasting Improvement in Food Preference and Body Weight Loss
    Anna Thorsø Larsen, Nina Sonne, Kim V. Andreassen, Morten A. Karsdal and Kim Henriksen
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 269-278; DOI: https://doi.org/10.1124/jpet.119.263400

Cardiovascular

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    COMT-Catalyzed Palmitic Acid Methyl Ester Biosynthesis in Perivascular Adipose Tissue and its Potential Role Against Hypertension
    Chin-Hung Liu, Hao-Jen Hsu, Tzu-Ling Tseng, Tsung-Jen Lin, Wei-Hsiang Weng, Mei-Fang Chen and Tony Jer-Fu Lee
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 175-183; DOI: https://doi.org/10.1124/jpet.119.263517

Cellular and Molecular

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    NO-Releasing Nanoparticles Ameliorate Detrusor Overactivity in Transgenic Sickle Cell Mice via Restored NO/ROCK Signaling
    Serkan Karakus, Biljana Musicki, Mahantesh S. Navati, Joel M. Friedman, Kelvin P. Davies and Arthur L. Burnett
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 214-219; DOI: https://doi.org/10.1124/jpet.119.264697
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    Distinct Regulation of σ1 Receptor Multimerization by Its Agonists and Antagonists in Transfected Cells and Rat Liver Membranes
    Weimin Conrad Hong
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 290-301; DOI: https://doi.org/10.1124/jpet.119.262790

Drug Discovery and Translational Medicine

  • Open Access
    A Mechanistic and Translational Pharmacokinetic-Pharmacodynamic Model of Abicipar Pegol and Vascular Endothelial Growth Factor Inhibition
    Kenneth T. Luu, Jennifer R. Seal and Mayssa Attar
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 184-192; DOI: https://doi.org/10.1124/jpet.119.263178
  • Pharmacological Characterization of Apraglutide, a Novel Long-Acting Peptidic Glucagon-Like Peptide-2 Agonist, for the Treatment of Short Bowel Syndrome
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    Pharmacological Characterization of Apraglutide, a Novel Long-Acting Peptidic Glucagon-Like Peptide-2 Agonist, for the Treatment of Short Bowel Syndrome
    Diane M. Hargrove, Sudarkodi Alagarsamy, Glenn Croston, Régent Laporte, Steve Qi, Karthik Srinivasan, Javier Sueiras-Diaz, Kazimierz Wiśniewski, Jennifer Hartwig, Mark Lu, Alexander P. Posch, Halina Wiśniewska, Claudio D. Schteingart, Pierre J.-M. Rivière and Violetta Dimitriadou
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 193-203; DOI: https://doi.org/10.1124/jpet.119.262238
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    Translational Pharmacokinetic-Pharmacodynamic Modeling for an Orally Available Novel Inhibitor of Epigenetic Regulator Enhancer of Zeste Homolog 2
    Shinji Yamazaki, Hovhannes J. Gukasyan, Hui Wang, Sean Uryu and Shikhar Sharma
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 220-229; DOI: https://doi.org/10.1124/jpet.119.263491
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    The Endocannabinoid System Alleviates Pain in a Murine Model of Cancer-Induced Bone Pain
    A.L. Thompson, S.A. Grenald, H.A. Ciccone, N. BassiriRad, M.J. Niphakis, B.F. Cravatt, T.M. Largent-Milnes and T.W. Vanderah
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 230-238; DOI: https://doi.org/10.1124/jpet.119.262337
  • You have access
    Inner Ear Arginine Vasopressin-Vasopressin Receptor 2-Aquaporin 2 Signaling Pathway Is Involved in the Induction of Motion Sickness
    Li-Hua Xu, Yao Yang, Hong-Xia Liu, Shui-Feng Xiao, Wen-Xia Qiu, Jin-Xing Wang, Chen-Chen Zhao, Yuan-Hong Gui, Gui-Zhu Liu, Bin Peng, Xia Li, Guo-Hua Wang, Xin Zhou and Zheng-Lin Jiang
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 248-260; DOI: https://doi.org/10.1124/jpet.119.264390

Gastrointestinal, Hepatic, Pulmonary, and Renal

  • You have access
    Mouse Colonic Epithelial Cells Functionally Express the Histamine H4 Receptor
    Bastian Schirmer, Luisa Lindemann, Kaya Saskia Bittkau, Rukijat Isaev, Daniela Bösche, Malte Juchem, Roland Seifert and Detlef Neumann
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 167-174; DOI: https://doi.org/10.1124/jpet.119.264408
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    KPR-5714, a Novel Transient Receptor Potential Melastatin 8 Antagonist, Improves Overactive Bladder via Inhibition of Bladder Afferent Hyperactivity in Rats
    Osamu Nakanishi, Yoshikazu Fujimori, Naoki Aizawa, Takemitsu Hayashi, Akane Matsuzawa, Jun-ichi Kobayashi, Hideaki Hirasawa, Yosuke Mutai, Fumiya Tanada and Yasuhiko Igawa
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 239-247; DOI: https://doi.org/10.1124/jpet.119.263616
  • You have access
    Cordycepin Inhibits Cancer Cell Proliferation and Angiogenesis through a DEK Interaction via ERK Signaling in Cholangiocarcinoma
    Tesi Liu, Guang Zhu, Wendi Yan, You Lv, Xue Wang, Guang Jin, Minghua Cui, Zhenhua Lin and Xiangshan Ren
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 279-289; DOI: https://doi.org/10.1124/jpet.119.263202

Inflammation, Immunopharmacology, and Asthma

  • You have access
    Cinnamaldehyde Inhibits Inflammation of Human Synoviocyte Cells Through Regulation of Jak/Stat Pathway and Ameliorates Collagen-Induced Arthritis in Rats
    Wen-Xiang Cheng, Shan Zhong, Xiang-Bo Meng, Nian-Ye Zheng, Peng Zhang, Yun Wang, Ling Qin and Xin-Luan Wang
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 302-310; DOI: https://doi.org/10.1124/jpet.119.262907

Metabolism, Transport, and Pharmacogenomics

  • Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk
    You have access
    Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk
    Katsuaki Ito, Noora Sjöstedt, Melina M. Malinen, Cen Guo and Kim L.R. Brouwer
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 261-268; DOI: https://doi.org/10.1124/jpet.119.263459

Neuropharmacology

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    Pharmacological Characterization of the Novel and Selective α7 Nicotinic Acetylcholine Receptor–Positive Allosteric Modulator BNC375
    Xiaohai Wang, Christopher Daley, Vanita Gakhar, Henry S. Lange, Joshua D. Vardigan, Michelle Pearson, Xiaoping Zhou, Lee Warren, Corin O. Miller, Michelle Belden, Andrew J. Harvey, Anton A. Grishin, Carolyn J. Coles, Susan M. O’Connor, Fiona Thomson, Joseph L. Duffy, Ian M. Bell and Jason M. Uslaner
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 311-324; DOI: https://doi.org/10.1124/jpet.119.263483
  • You have access
    Pre-eclamptic Fetal Programming Alters Neuroinflammatory and Cardiovascular Consequences of Endotoxemia in Sex-Specific Manners
    Salwa A. Abuiessa, Abdalla M. Wedn, Sahar M. El-Gowilly, Mai M. Helmy and Mahmoud M. El-Mas
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 325-336; DOI: https://doi.org/10.1124/jpet.119.264192

Erratum

  • You have access
    Correction to “Probing the Assembly of HDL Mimetic, Drug Carrying Nanoparticles Using Intrinsic Fluorescence”
    Journal of Pharmacology and Experimental Therapeutics May 2020, 373 (2) 213; DOI: https://doi.org/10.1124/jpet.119.262899err
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 373 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 373, Issue 2
1 May 2020
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
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  • Editorial Board (PDF)
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  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
  • Erratum
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  • Potential Clinical Uses of CBG
  • Ocular Drug Delivery: Past, Present, and Future
  • Nose-to-Brain Delivery
  • Antipsychotic-VMAT2 Inhibitor Synergy: Schizophrenia Models
  • SEP-363856, a Novel, Non-D2 Psychotropic Agent
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