Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal
Open Access
CSTI-300 (SMP-100); a Novel 5-HT3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome
Alexander Roberts, Gillian Grafton, Andrew D. Powell, Kristian Brock, Chunlin Chen, Dejian Xie, Jinkun Huang, Shuang Liu, Alison J. Cooper, Catherine A. Brady, Omar Qureshi, Zania Stamataki, David D. Manning, Nicholas A. Moore, Bruce J. Sargent, Peter R. Guzzo and Nicholas M. Barnes
Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 122-134; DOI: https://doi.org/10.1124/jpet.119.261008
Alexander Roberts
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Gillian Grafton
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Andrew D. Powell
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Kristian Brock
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Chunlin Chen
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Dejian Xie
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Jinkun Huang
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Shuang Liu
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Alison J. Cooper
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Catherine A. Brady
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Omar Qureshi
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Zania Stamataki
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
David D. Manning
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Nicholas A. Moore
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Bruce J. Sargent
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Peter R. Guzzo
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Nicholas M. Barnes
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
Article Information
vol. 373 no. 1 122-134
PubMed
Print ISSN
Online ISSN
History
- Received June 26, 2019
- Accepted January 24, 2020
- Published online March 16, 2020.
Article Versions
- Earlier version (February 26, 2020 - 08:14).
- You are viewing the most recent version of this article.
Copyright & Usage
Copyright © 2020 The Author(s). This is an open access article distributed under the CC BY Attribution 4.0 International license.
Author Information
- Alexander Roberts,
- Gillian Grafton,
- Andrew D. Powell,
- Kristian Brock,
- Chunlin Chen,
- Dejian Xie,
- Jinkun Huang,
- Shuang Liu,
- Alison J. Cooper,
- Catherine A. Brady,
- Omar Qureshi,
- Zania Stamataki,
- David D. Manning,
- Nicholas A. Moore,
- Bruce J. Sargent,
- Peter R. Guzzo, and
- Nicholas M. Barnes
- Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB – Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
- Address correspondence to:
Nicholas Barnes, Neuropharmacology Research Group, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT UK. E-mail: n.m.barnes{at}bham.ac.uk
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Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal
CSTI-300 Could Treat Patients with Gastrointestinal Ailments
Alexander Roberts, Gillian Grafton, Andrew D. Powell, Kristian Brock, Chunlin Chen, Dejian Xie, Jinkun Huang, Shuang Liu, Alison J. Cooper, Catherine A. Brady, Omar Qureshi, Zania Stamataki, David D. Manning, Nicholas A. Moore, Bruce J. Sargent, Peter R. Guzzo and Nicholas M. Barnes
Journal of Pharmacology and Experimental Therapeutics April 1, 2020, 373 (1) 122-134; DOI: https://doi.org/10.1124/jpet.119.261008
Research ArticleGastrointestinal, Hepatic, Pulmonary, and Renal
CSTI-300 Could Treat Patients with Gastrointestinal Ailments
Alexander Roberts, Gillian Grafton, Andrew D. Powell, Kristian Brock, Chunlin Chen, Dejian Xie, Jinkun Huang, Shuang Liu, Alison J. Cooper, Catherine A. Brady, Omar Qureshi, Zania Stamataki, David D. Manning, Nicholas A. Moore, Bruce J. Sargent, Peter R. Guzzo and Nicholas M. Barnes
Journal of Pharmacology and Experimental Therapeutics April 1, 2020, 373 (1) 122-134; DOI: https://doi.org/10.1124/jpet.119.261008
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