Journal of Pharmacology and Experimental Therapeutics: 373 (1)

April 01, 2020; Volume 373,Issue 1

Behavioral Pharmacology

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Mice with GNAO1 R209H Movement Disorder Variant Display Hyperlocomotion Alleviated by Risperidone
Casandra L. Larrivee, Huijie Feng, Josiah A. Quinn, Vincent S. Shaw, Jeffrey R. Leipprandt, Elena Y. Demireva, Huirong Xie and Richard R. Neubig

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 24-33; DOI: https://doi.org/10.1124/jpet.119.262733
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Cannabinoid Modulation of Food-Cocaine Choice in Male Rhesus Monkeys
William S. John, Thomas J. Martin and Michael A. Nader

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 44-50; DOI: https://doi.org/10.1124/jpet.119.263707
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Enhancing KCNQ Channel Activity Improves Neurobehavioral Recovery after Spinal Cord Injury
Zizhen Wu, Lin Li, Fuhua Xie, Guoying Xu, Danny Dang and Qing Yang

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 72-80; DOI: https://doi.org/10.1124/jpet.119.264010
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NR2A-NMDA Receptor Blockade Reverses the Lack of Morphine Analgesia Without Affecting Chronic Pain Status in a Fibromyalgia-Like Mouse Model
Hiroyuki Neyama, Naoki Dozono and Hiroshi Ueda

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 103-112; DOI: https://doi.org/10.1124/jpet.119.262642

Open Access
Heparin-Binding Copolymer as a Complete Antidote for Low-Molecular-Weight Heparins in Rats
Bartlomiej Kalaska, Joanna Miklosz, Kamil Kamiński, Justyna Swieton, Aleksandra Jakimczuk, Shin-Ichi Yusa, Dariusz Pawlak, Maria Nowakowska, Krzysztof Szczubiałka and Andrzej Mogielnicki

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 51-61; DOI: https://doi.org/10.1124/jpet.119.262931
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The Dual Amylin and Calcitonin Receptor Agonist, KBP-066, Induces an Equally Potent Weight Loss Across a Broad Dose Range While Higher Doses May Further Improve Insulin Action
Nina Sonne, Anna Thorsø Larsen, Kim Vietz Andreassen, Morten Asser Karsdal and Kim Henriksen

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 92-102; DOI: https://doi.org/10.1124/jpet.119.263723
Open Access
CDDO-Me Elicits Anti–Breast Cancer Activity by Targeting LRP6 and FZD7 Receptor Complex
Liang Zhou, Zhongyuan Wang, Shubin Yu, Yanpeng Xiong, Jiaoyang Fan, Yansi Lyu, Zijie Su, Jiaxing Song, Shanshan Liu, Qi Sun and Desheng Lu

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 149-159; DOI: https://doi.org/10.1124/jpet.119.263434

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Oleoylethanolamide Increases Glycogen Synthesis and Inhibits Hepatic Gluconeogenesis via the LKB1/AMPK Pathway in Type 2 Diabetic Model
Tong Ren, Ang Ma, Rengong Zhuo, Huaying Zhang, Lu Peng, Xin Jin, Enhui Yao and Lichao Yang

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 81-91; DOI: https://doi.org/10.1124/jpet.119.262675

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Leukotriene B₄ Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation
Yui Matsumoto, Yukiko Matsuya, Kano Nagai, Kikuko Amagase, Kazuko Saeki, Kenjiro Matsumoto, Takehiko Yokomizo and Shinichi Kato

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 1-9; DOI: https://doi.org/10.1124/jpet.119.263145
Open Access
CSTI-300 (SMP-100); a Novel 5-HT₃ Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome
Alexander Roberts, Gillian Grafton, Andrew D. Powell, Kristian Brock, Chunlin Chen, Dejian Xie, Jinkun Huang, Shuang Liu, Alison J. Cooper, Catherine A. Brady, Omar Qureshi, Zania Stamataki, David D. Manning, Nicholas A. Moore, Bruce J. Sargent, Peter R. Guzzo and Nicholas M. Barnes

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 122-134; DOI: https://doi.org/10.1124/jpet.119.261008

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Probing the Assembly of HDL Mimetic, Drug Carrying Nanoparticles Using Intrinsic Fluorescence
Sangram Raut, Ashwini Garud, Bhavani Nagarajan, Nirupama Sabnis, Alan Remaley, Rafal Fudala, Ignacy Gryczynski, Zygmunt Gryczynski, Sergei V. Dzyuba, Julian Borejdo and Andras Lacko

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 113-121; DOI: https://doi.org/10.1124/jpet.119.262899

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Dorsoventral-Specific Effects of Nerve Agent Surrogate Diisopropylfluorophosphate on Synaptic Transmission in the Mouse Hippocampus
Kyle A. Brown, Nikolay M. Filipov and John J. Wagner

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 10-23; DOI: https://doi.org/10.1124/jpet.119.263053
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Detailed In Vitro Pharmacological Characterization of the Clinically Viable Nociceptin/Orphanin FQ Peptide Receptor Antagonist BTRX-246040
Federica Ferrari, Sabrina Rizzo, Chiara Ruzza and Girolamo Calo

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 34-43; DOI: https://doi.org/10.1124/jpet.119.262865
Open Access
Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor
Eric Moore, Mark E. Fraley, Ian M. Bell, Christopher S. Burgey, Rebecca B. White, Chi-Chung Li, Christopher P. Regan, Andrew Danziger, Maria Stranieri Michener, Eric Hostetler, Pradeep Banerjee and Christopher Salvatore

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 160-166; DOI: https://doi.org/10.1124/jpet.119.261065

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Arsenite-Induced Mitochondrial Superoxide Formation: Time and Concentration Requirements for the Effects of the Metalloid on the Endoplasmic Reticulum and Mitochondria
Andrea Guidarelli, Liana Cerioni, Mara Fiorani, Alessia Catalani and Orazio Cantoni

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 62-71; DOI: https://doi.org/10.1124/jpet.119.262469