Journal of Pharmacology and Experimental Therapeutics: 372 (3)

March 01, 2020; Volume 372,Issue 3

Minireviews

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Profiling of Drug-Metabolizing Enzymes and Transporters in Human Tissue Biopsy Samples: A Review of the Literature
A. David Rodrigues and Andrew Rowland

Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 308-319; DOI: https://doi.org/10.1124/jpet.119.262972

Behavioral Pharmacology

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Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam
Shu-Hui Chuang and Doodipala Samba Reddy

Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 285-298; DOI: https://doi.org/10.1124/jpet.119.261735

Cardiovascular

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Menaquinone-4 Accelerates Calcification of Human Aortic Valve Interstitial Cells in High-Phosphate Medium through PXR
Wei Yang, Zaiqiang Yu, Mari Chiyoya, Xu Liu, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa, Motonori Tsuji and Kazuhiko Seya

Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 277-284; DOI: https://doi.org/10.1124/jpet.119.263160

Cellular and Molecular

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Long Noncoding RNA MNX1 antisense RNA 1 Exerts Oncogenic Functions in Bladder Cancer by Regulating miR-218-5p/RAB1A Axis
Jun Wang, Huiwu Xing, Abdul Aziz Nikzad, Bowen Liu, Yu Zhang, Songchao Li, Erwei Zhang and Zhankui Jia

Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 237-247; DOI: https://doi.org/10.1124/jpet.119.262949

Chemotherapy, Antibiotics, and Gene Therapy

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A Bicistronic Plasmid Encoding Brain-Derived Neurotrophic Factor and Urokinase Plasminogen Activator Stimulates Peripheral Nerve Regeneration After Injury
Maxim Karagyaur, Alexandra Rostovtseva, Ekaterina Semina, Polina Klimovich, Vadim Balabanyan, Pavel Makarevich, Vladimir Popov, Dmitry Stambolsky and Vsevolod Tkachuk

Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 248-255; DOI: https://doi.org/10.1124/jpet.119.261594

Drug Discovery and Translational Medicine

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A Quantitative Systems Pharmacology Model for the Key Interleukins Involved in Crohn's Disease
Violeta Balbas-Martinez, Eduardo Asin-Prieto, Zinnia P. Parra-Guillen and Iñaki F. Troconiz

Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 299-307; DOI: https://doi.org/10.1124/jpet.119.260539
Open Access
Relative Selectivity of Covalent Inhibitors Requires Assessment of Inactivation Kinetics and Cellular Occupancy: A Case Study of Ibrutinib and Acalabrutinib
Melissa Hopper, Tarikere Gururaja, Taisei Kinoshita, James P. Dean, Ronald J. Hill and Ann Mongan

Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 331-338; DOI: https://doi.org/10.1124/jpet.119.262063
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Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor
Ryan M. Wyatt, Ian Fraser, Natalie Welty, Brian Lord, Michelle Wennerholm, Steven Sutton, Michael K. Ameriks, Christine Dugovic, Sujin Yun, Allison White, Leslie Nguyen, Tatiana Koudriakova, Gaochao Tian, Javier Suarez, Lawrence Szewczuk, William Bonnette, Kay Ahn, Brahma Ghosh, Christopher M. Flores, Peter J. Connolly, Bin Zhu, Mark J. Macielag, Michael R. Brandt, Kristen Chevalier, Sui-Po Zhang, Timothy Lovenberg and Pascal Bonaventure

Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 339-353; DOI: https://doi.org/10.1124/jpet.119.262139

Endocrine and Diabetes

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A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways
Hiroyuki Takagi, Keiichi Tanimoto, Atsuyuki Shimazaki, Yutaka Tonomura, Sotaro Momosaki, Shingo Sakamoto, Kohji Abe, Mitsuru Notoya and Hideo Yukioka

Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 256-263; DOI: https://doi.org/10.1124/jpet.119.263590

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Carbon Monoxide Rescues the Developmental Lethality of Experimental Rat Models of Rhabdomyolysis-Induced Acute Kidney Injury
Kazuaki Taguchi, Shigeru Ogaki, Taisei Nagasaki, Hiroki Yanagisawa, Kento Nishida, Hitoshi Maeda, Yuki Enoki, Kazuaki Matsumoto, Hidehisa Sekijima, Kazuya Ooi, Yu Ishima, Hiroshi Watanabe, Masafumi Fukagawa, Masaki Otagiri and Toru Maruyama

Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 355-365; DOI: https://doi.org/10.1124/jpet.119.262485

Metabolism, Transport, and Pharmacogenomics

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From Genotype to Phenotype: Content and Activities of Cytochromes P450 2A6 in Human Liver In Vitro and Predicted In Vivo
Yan Fang, Tong Wang, Yuan-Yuan Guo, Hai-Feng Zhang, Qiang Wen, Yu-Rong Xing, Na Gao and Hai-Ling Qiao

Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 320-330; DOI: https://doi.org/10.1124/jpet.119.263152

Neuropharmacology

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Genome-Wide Small Interfering RNA Screening Reveals a Role for Cullin3–Really Interesting New Gene Ligase Signaling in Heterologous Sensitization of Adenylyl Cyclase
Zhong Ding, Karin F.K. Ejendal, Monica Soto-Velasquez, Michael P. Hayes, Nicholas Santoro, Martha J. Larsen and Val J. Watts

Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 267-276; DOI: https://doi.org/10.1124/jpet.119.261255

Errata

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Correction to “M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body β-Hydroxybutyrate”
Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 264; DOI: https://doi.org/10.1124/jpet.119.263350err
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Correction to “Pharmacological Activation of Thermo–Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath”
Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 265; DOI: https://doi.org/10.1124/jpet.119.258087err
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Correction to “Selective Cannabinoid 2 Receptor Stimulation Reduces Tubular Epithelial Cell Damage after Renal Ischemia-Reperfusion Injury”
Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 266; DOI: https://doi.org/10.1124/jpet.118.245522err
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Correction to “Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: SLC-Phenotyping Using Primary Human Hepatocytes”
Journal of Pharmacology and Experimental Therapeutics March 2020, 372 (3) 354; DOI: https://doi.org/10.1124/jpet.119.257600err

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Table of Contents

Minireviews

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Errata

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