Journal of Pharmacology and Experimental Therapeutics: 372 (1)

January 01, 2020; Volume 372,Issue 1

Commentary

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New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology
Martin C. Michel, T.J. Murphy and Harvey J. Motulsky

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 136-147; DOI: https://doi.org/10.1124/jpet.119.264143

Minireviews

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A Compendium of the Biological Effects of Apolipoprotein A-I_Milano
Cinzia Parolini

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 54-62; DOI: https://doi.org/10.1124/jpet.119.261719

Behavioral Pharmacology

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The Novel CYP2A6 Inhibitor, DLCI-1, Decreases Nicotine Self-Administration in Mice
Yen-Chu Chen, James P. Fowler, Jing Wang, Christy J. W. Watson, Yasmine Sherafat, Andres Staben, Philip Lazarus, Travis T. Denton and Christie D. Fowler

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 21-29; DOI: https://doi.org/10.1124/jpet.119.260653
Open Access
The Neuropeptide Y Y₂ Receptor Is Coexpressed with Nppb in Primary Afferent Neurons and Y₂ Activation Reduces Histaminergic and IL-31-Induced Itch
Haisha Ma, Tianle Gao, Jon E.T. Jakobsson, Hannah M. Weman, Bo Xu, Dan Larhammar and Malin C. Lagerström

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 73-82; DOI: https://doi.org/10.1124/jpet.119.262584
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Cannabinoid Antagonist Drug Discrimination in Nonhuman Primates
Brian D. Kangas, Ani S. Zakarian, Kiran Vemuri, Shakiru O. Alapafuja, Shan Jiang, Spyros P. Nikas, Alexandros Makriyannis and Jack Bergman

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 119-127; DOI: https://doi.org/10.1124/jpet.119.261818
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Inhibiting MicroRNA-29a Protects Myocardial Ischemia-Reperfusion Injury by Targeting SIRT1 and Suppressing Oxidative Stress and NLRP3-Mediated Pyroptosis Pathway
Shoukun Ding, Donghai Liu, Lixia Wang, Guanggong Wang and Yaobin Zhu

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 128-135; DOI: https://doi.org/10.1124/jpet.119.256982

Cardiovascular

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Complex Effects of Putative DRP-1 Inhibitors on Stress Responses in Mouse Heart and Rat Cardiomyoblasts
Lauren Wendt, Jelena Vider, Louise E. See Hoe, Eugene Du Toit, Jason N. Peart and John P. Headrick

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 95-106; DOI: https://doi.org/10.1124/jpet.119.258897

Drug Discovery and Translational Medicine

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The Positive Allosteric Modulator of α2/3-Containing GABA_A Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury
Jeffrey M. Witkin, Guanguan Li, Lalit K. Golani, Wenhui Xiong, Jodi L. Smith, Xingjie Ping, Farjana Rashid, Rajwana Jahan, Rok Cerne, James M. Cook and Xiaoming Jin

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 83-94; DOI: https://doi.org/10.1124/jpet.119.260968
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Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222
Ashvani K. Singh, Yihong Fan, Corina Balut, Sara Alani, Arlene M. Manelli, Andrew M. Swensen, Ying Jia, Torben R. Neelands, Timothy A. Vortherms, Bo Liu, Xenia B. Searle, Xueqing Wang, Wenqing Gao, Tzyh-Chang Hwang, Hong Y. Ren, Douglas Cyr, Philip R. Kym, Katja Conrath and Chris Tse

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 107-118; DOI: https://doi.org/10.1124/jpet.119.261800

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Activation of Prejunctional P2x2/3 Heterotrimers by ATP Enhances the Cholinergic Tone in Obstructed Human Urinary Bladders
M. Silva-Ramos, I. Silva, M. Faria, F. Ferreirinha and P. Correia-de-Sá

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 63-72; DOI: https://doi.org/10.1124/jpet.119.261610

Metabolism, Transport, and Pharmacogenomics

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Sampling Site Has a Critical Impact on Physiologically Based Pharmacokinetic Modeling
Weize Huang and Nina Isoherranen

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 30-45; DOI: https://doi.org/10.1124/jpet.119.262154
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Plasma Membrane Cholesterol Regulates the Allosteric Binding of 1-Methyl-4-Phenylpyridinium to Organic Cation Transporter 2 (SLC22A2)
Severin Hörmann, Zhibo Gai, Gerd A. Kullak-Ublick and Michele Visentin

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 46-53; DOI: https://doi.org/10.1124/jpet.119.260877

Neuropharmacology

Open Access
Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Interactions with Synaptic Vesicle 2 Proteins and the GABA_A Receptor
Martyn Wood, Veronique Daniels, Laurent Provins, Christian Wolff, Rafal M. Kaminski and Michel Gillard

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 1-10; DOI: https://doi.org/10.1124/jpet.119.261149
Open Access
Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models
Karine Leclercq, Alain Matagne, Laurent Provins, Henrik Klitgaard and Rafal M. Kaminski

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 11-20; DOI: https://doi.org/10.1124/jpet.119.261222

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Table of Contents

Commentary

Minireviews

Behavioral Pharmacology

Cardiovascular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

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