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Research ArticleDrug Discovery and Translational Medicine

Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase

John S. Lazo, Isabella K. Blanco, Nikhil R. Tasker, Ettore J. Rastelli, James C. Burnett, Sharon R. Garrott, Duncan J. Hart, Rebecca L. McCloud, Ku-Lung Hsu, Peter Wipf and Elizabeth R. Sharlow
Journal of Pharmacology and Experimental Therapeutics December 2019, 371 (3) 652-662; DOI: https://doi.org/10.1124/jpet.119.262188
John S. Lazo
Departments of Pharmacology (J.S.L., I.K.B., S.R.G., D.J.H., E.R.S.) and Chemistry (J.S.L., R.L.M., K.-L.H.), University of Virginia, Charlottesville, Virginia; and Department of Chemistry (N.R.T., E.J.R., J.C.B., P.W.), University of Pittsburgh, Pittsburgh, Pennsylvania
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Isabella K. Blanco
Departments of Pharmacology (J.S.L., I.K.B., S.R.G., D.J.H., E.R.S.) and Chemistry (J.S.L., R.L.M., K.-L.H.), University of Virginia, Charlottesville, Virginia; and Department of Chemistry (N.R.T., E.J.R., J.C.B., P.W.), University of Pittsburgh, Pittsburgh, Pennsylvania
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Nikhil R. Tasker
Departments of Pharmacology (J.S.L., I.K.B., S.R.G., D.J.H., E.R.S.) and Chemistry (J.S.L., R.L.M., K.-L.H.), University of Virginia, Charlottesville, Virginia; and Department of Chemistry (N.R.T., E.J.R., J.C.B., P.W.), University of Pittsburgh, Pittsburgh, Pennsylvania
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Ettore J. Rastelli
Departments of Pharmacology (J.S.L., I.K.B., S.R.G., D.J.H., E.R.S.) and Chemistry (J.S.L., R.L.M., K.-L.H.), University of Virginia, Charlottesville, Virginia; and Department of Chemistry (N.R.T., E.J.R., J.C.B., P.W.), University of Pittsburgh, Pittsburgh, Pennsylvania
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James C. Burnett
Departments of Pharmacology (J.S.L., I.K.B., S.R.G., D.J.H., E.R.S.) and Chemistry (J.S.L., R.L.M., K.-L.H.), University of Virginia, Charlottesville, Virginia; and Department of Chemistry (N.R.T., E.J.R., J.C.B., P.W.), University of Pittsburgh, Pittsburgh, Pennsylvania
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Sharon R. Garrott
Departments of Pharmacology (J.S.L., I.K.B., S.R.G., D.J.H., E.R.S.) and Chemistry (J.S.L., R.L.M., K.-L.H.), University of Virginia, Charlottesville, Virginia; and Department of Chemistry (N.R.T., E.J.R., J.C.B., P.W.), University of Pittsburgh, Pittsburgh, Pennsylvania
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Duncan J. Hart
Departments of Pharmacology (J.S.L., I.K.B., S.R.G., D.J.H., E.R.S.) and Chemistry (J.S.L., R.L.M., K.-L.H.), University of Virginia, Charlottesville, Virginia; and Department of Chemistry (N.R.T., E.J.R., J.C.B., P.W.), University of Pittsburgh, Pittsburgh, Pennsylvania
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Rebecca L. McCloud
Departments of Pharmacology (J.S.L., I.K.B., S.R.G., D.J.H., E.R.S.) and Chemistry (J.S.L., R.L.M., K.-L.H.), University of Virginia, Charlottesville, Virginia; and Department of Chemistry (N.R.T., E.J.R., J.C.B., P.W.), University of Pittsburgh, Pittsburgh, Pennsylvania
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Ku-Lung Hsu
Departments of Pharmacology (J.S.L., I.K.B., S.R.G., D.J.H., E.R.S.) and Chemistry (J.S.L., R.L.M., K.-L.H.), University of Virginia, Charlottesville, Virginia; and Department of Chemistry (N.R.T., E.J.R., J.C.B., P.W.), University of Pittsburgh, Pittsburgh, Pennsylvania
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Peter Wipf
Departments of Pharmacology (J.S.L., I.K.B., S.R.G., D.J.H., E.R.S.) and Chemistry (J.S.L., R.L.M., K.-L.H.), University of Virginia, Charlottesville, Virginia; and Department of Chemistry (N.R.T., E.J.R., J.C.B., P.W.), University of Pittsburgh, Pittsburgh, Pennsylvania
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Elizabeth R. Sharlow
Departments of Pharmacology (J.S.L., I.K.B., S.R.G., D.J.H., E.R.S.) and Chemistry (J.S.L., R.L.M., K.-L.H.), University of Virginia, Charlottesville, Virginia; and Department of Chemistry (N.R.T., E.J.R., J.C.B., P.W.), University of Pittsburgh, Pittsburgh, Pennsylvania
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Article Information

vol. 371 no. 3 652-662
DOI 
https://doi.org/10.1124/jpet.119.262188
PubMed 
31601683

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received August 19, 2019
  • Accepted October 3, 2019
  • Published online November 12, 2019.

Article Versions

  • Earlier version (October 10, 2019 - 08:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. John S. Lazo,
  2. Isabella K. Blanco,
  3. Nikhil R. Tasker,
  4. Ettore J. Rastelli,
  5. James C. Burnett,
  6. Sharon R. Garrott,
  7. Duncan J. Hart,
  8. Rebecca L. McCloud,
  9. Ku-Lung Hsu,
  10. Peter Wipf, and
  11. Elizabeth R. Sharlow
  1. Departments of Pharmacology (J.S.L., I.K.B., S.R.G., D.J.H., E.R.S.) and Chemistry (J.S.L., R.L.M., K.-L.H.), University of Virginia, Charlottesville, Virginia; and Department of Chemistry (N.R.T., E.J.R., J.C.B., P.W.), University of Pittsburgh, Pittsburgh, Pennsylvania
  1. Address correspondence to:
    John S. Lazo, Department of Pharmacology, Fiske Drug Discovery Laboratory, P.O. Box 800735, University of Virginia, Charlottesville, VA 22908-0735. E-mail: lazo{at}virginia.edu
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Journal of Pharmacology and Experimental Therapeutics: 371 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 371, Issue 3
1 Dec 2019
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Research ArticleDrug Discovery and Translational Medicine

Iminothienopyridinedione PTP4A Phosphatase Inhibitors

John S. Lazo, Isabella K. Blanco, Nikhil R. Tasker, Ettore J. Rastelli, James C. Burnett, Sharon R. Garrott, Duncan J. Hart, Rebecca L. McCloud, Ku-Lung Hsu, Peter Wipf and Elizabeth R. Sharlow
Journal of Pharmacology and Experimental Therapeutics December 1, 2019, 371 (3) 652-662; DOI: https://doi.org/10.1124/jpet.119.262188

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Research ArticleDrug Discovery and Translational Medicine

Iminothienopyridinedione PTP4A Phosphatase Inhibitors

John S. Lazo, Isabella K. Blanco, Nikhil R. Tasker, Ettore J. Rastelli, James C. Burnett, Sharon R. Garrott, Duncan J. Hart, Rebecca L. McCloud, Ku-Lung Hsu, Peter Wipf and Elizabeth R. Sharlow
Journal of Pharmacology and Experimental Therapeutics December 1, 2019, 371 (3) 652-662; DOI: https://doi.org/10.1124/jpet.119.262188
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