Table of Contents

Drug Discovery and Translational Medicine

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  Utilization of ¹⁸F-Fluorodeoxyglucose–Positron Emission Tomography To Understand the Mechanism of Nicotinamide Phosphoribosyltransferase Inhibitors In Vivo

  Sarah R. Mudd, Martin J. Voorbach, Dong Cheng, Min Cheng, Jun Guo, Wenqing Gao, Fritz G. Buchanan, Chris Tse and Julie Wilsbacher

  Journal of Pharmacology and Experimental Therapeutics December 2019, 371 (3) 583-589; DOI: https://doi.org/10.1124/jpet.119.259135
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  The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents

  Holger Rosenbrock, Riccardo Giovannini, Gerhard Schänzle, Eliza Koros, Frank Runge, Holger Fuchs, Anelise Marti, Klaus G. Reymann, Ulrich H. Schröder, Ernesto Fedele and Cornelia Dorner-Ciossek

  Journal of Pharmacology and Experimental Therapeutics December 2019, 371 (3) 633-641; DOI: https://doi.org/10.1124/jpet.119.260059
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  Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase

  John S. Lazo, Isabella K. Blanco, Nikhil R. Tasker, Ettore J. Rastelli, James C. Burnett, Sharon R. Garrott, Duncan J. Hart, Rebecca L. McCloud, Ku-Lung Hsu, Peter Wipf and Elizabeth R. Sharlow

  Journal of Pharmacology and Experimental Therapeutics December 2019, 371 (3) 652-662; DOI: https://doi.org/10.1124/jpet.119.262188
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  A Novel Phosphodiesterase 1 Inhibitor DSR-141562 Exhibits Efficacies in Animal Models for Positive, Negative, and Cognitive Symptoms Associated with Schizophrenia

  Takeshi Enomoto, Ayaka Tatara, Masao Goda, Yohei Nishizato, Kantaro Nishigori, Atsushi Kitamura, Mami Kamada, Shiori Taga, Takashi Hashimoto, Kazuhito Ikeda and Yuki Fujii

  Journal of Pharmacology and Experimental Therapeutics December 2019, 371 (3) 692-702; DOI: https://doi.org/10.1124/jpet.119.260869
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  A Novel Small Molecule Inhibits Tumor Growth and Synergizes Effects of Enzalutamide on Prostate Cancer

  Jiongjia Cheng, Stephanie Moore, Jorge Gomez-Galeno, Dong-Hoon Lee, Karl J. Okolotowicz and John R. Cashman

  Journal of Pharmacology and Experimental Therapeutics December 2019, 371 (3) 703-712; DOI: https://doi.org/10.1124/jpet.119.261040