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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

November 01, 2019; Volume 371,Issue 2

Special Section on The Opioid Crisis

  • You have access
    Translating Pharmacology into Therapeutics to Fight the Opioid Crisis
    Gerard J. Marek, Kathryn A. Cunningham and Kurt Rasmussen
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 394-395; DOI: https://doi.org/10.1124/jpet.119.262477
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    The Opioid Crisis and the Future of Addiction and Pain Therapeutics
    Nathan P. Coussens, G. Sitta Sittampalam, Samantha G. Jonson, Matthew D. Hall, Heather E. Gorby, Amir P. Tamiz, Owen B. McManus, Christian C. Felder and Kurt Rasmussen
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 396-408; DOI: https://doi.org/10.1124/jpet.119.259408
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    Fighting Fire with Fire: Development of Intranasal Nalmefene to Treat Synthetic Opioid Overdose
    Philip Krieter, Shwe Gyaw, Roger Crystal and Phil Skolnick
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 409-415; DOI: https://doi.org/10.1124/jpet.118.256115
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    A Pragmatic Utility Function to Describe the Risk-Benefit Composite of Opioid and Nonopioid Analgesic Medication
    Anne E. Olesen, Suzanne Broens, Søren S. Olesen, Marieke Niesters, Monique van Velzen, Asbjørn M. Drewes, Albert Dahan and Erik Olofsen
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 416-421; DOI: https://doi.org/10.1124/jpet.118.253716
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    Non-Opioid Neurotransmitter Systems that Contribute to the Opioid Withdrawal Syndrome: A Review of Preclinical and Human Evidence
    Kelly E. Dunn, Andrew S. Huhn, Cecilia L. Bergeria, Cassandra D. Gipson and Elise M. Weerts
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 422-452; DOI: https://doi.org/10.1124/jpet.119.258004
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    Noradrenergic Mechanisms in Fentanyl-Mediated Rapid Death Explain Failure of Naloxone in the Opioid Crisis
    Randy Torralva and Aaron Janowsky
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 453-475; DOI: https://doi.org/10.1124/jpet.119.258566
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    Pharmacological Assessment of Sepiapterin Reductase Inhibition on Tactile Response in the Rat
    James T. Meyer, Brian A. Sparling, William J. McCarty, Maosheng Zhang, Marcus Soto, Stephen Schneider, Hao Chen, Jonathan Roberts, Helming Tan, Thomas Kornecook, Paul S. Andrews and Charles G. Knutson
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 476-486; DOI: https://doi.org/10.1124/jpet.119.257105
  • Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine
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    Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine
    Shane W. Kaski, Allison N. White, Joshua D. Gross, Kristen R. Trexler, Kim Wix, Aubrie A. Harland, Thomas E. Prisinzano, Jeffrey Aubé, Steven G. Kinsey, Terry Kenakin, David P. Siderovski and Vincent Setola
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 487-499; DOI: https://doi.org/10.1124/jpet.118.255661
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    Addressing the Opioid Crisis: Medical Student Instruction in Opioid Drug Pharmacology, Pain Management, and Substance Use Disorders
    Brian M. Cox, Thomas E. Cote and Irwin Lucki
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 500-506; DOI: https://doi.org/10.1124/jpet.119.257329

Behavioral Pharmacology

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    Methocinnamox Produces Long-Lasting Antagonism of the Behavioral Effects of µ-Opioid Receptor Agonists but Not Prolonged Precipitated Withdrawal in Rats
    Lisa R. Gerak, Vanessa Minervini, Elizabeth Latham, Saba Ghodrati, Katherine V. Lillis, Jessica Wooden, Alex Disney, Stephen M. Husbands and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 507-516; DOI: https://doi.org/10.1124/jpet.119.260331
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    Behavioral Effects of Opioid Full and Partial Agonists During Chronic Buprenorphine Treatment
    Sarah L. Withey, Roger D. Spealman, Jack Bergman and Carol A. Paronis
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 544-554; DOI: https://doi.org/10.1124/jpet.119.259010

Cardiovascular

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    Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow
    Amanda J. Stolarz, Mustafa Sarimollaoglu, John C. Marecki, Terry W. Fletcher, Ekaterina I. Galanzha, Sung W. Rhee, Vladimir P. Zharov, V. Suzanne Klimberg and Nancy J. Rusch
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 278-289; DOI: https://doi.org/10.1124/jpet.119.257592
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    A Novel Orally Available Delta-5 Desaturase Inhibitor Prevents Atherosclerotic Lesions Accompanied by Changes in Fatty Acid Composition and Eicosanoid Production in ApoE Knockout Mice
    Shuichi Takagahara, Hiromi Shinohara, Shigekazu Itokawa, Yoshinori Satomi, Ayumi Ando, Takeshi Yamamoto, Hideo Suzuki, Takuya Fujimoto, Kazuki Kubo and Shota Ikeda
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 290-298; DOI: https://doi.org/10.1124/jpet.119.259846
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    Indigo Fruits Ingredient, Aucubin, Protects against LPS-Induced Cardiac Dysfunction in Mice
    MingXia Duan, Yuan Yuan, Chen Liu, Zhulan Cai, Qingwen Xie, Tongtong Hu, Qizhu Tang and QingQing Wu
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 348-359; DOI: https://doi.org/10.1124/jpet.119.259069

Drug Discovery and Translational Medicine

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    Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors
    Pamela J. Farrell, Christopher J. Zopf, Huey-Jing Huang, Deepika Balakrishna, Corine Holub, James Bilakovics, Andrea Fanjul, Jennifer Matuszkiewicz, Artur Plonowski, Paul Rolzin, Urmi Banerjee, Jacques Ermolieff, Zacharia S. Cheruvallath, Christopher McBride, Darian Bartkowski, Crystal Mazur, Alok Pachori and Christopher J. Larson
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 299-308; DOI: https://doi.org/10.1124/jpet.119.259028
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    In Vivo Evaluation of Isoprenoid Triazole Bisphosphonate Inhibitors of Geranylgeranyl Diphosphate Synthase: Impact of Olefin Stereochemistry on Toxicity and Biodistribution
    Staci L. Haney, Yashpal S. Chhonker, Michelle L. Varney, Geoffrey Talmon, Lynette M. Smith, Daryl J. Murry and Sarah A. Holstein
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 327-338; DOI: https://doi.org/10.1124/jpet.119.258624
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    Pharmacological Profile of JNJ-64179375: A Novel, Long-Acting Exosite-1 Thrombin Inhibitor
    Zheng Huang Devine, Fuyong Du, Qiu Li, Matthew Bunce, Eilyn R. Lacy and Madhu Chintala
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 375-384; DOI: https://doi.org/10.1124/jpet.119.261032

Endocrine And Diabetes

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    Oral Phenelzine Treatment Mitigates Metabolic Disturbances in Mice Fed a High-Fat Diet
    Josep Mercader, Agustín G. Sabater, Sophie Le Gonidec, Pauline Decaunes, Alice Chaplin, Saioa Gómez-Zorita, Fermín I. Milagro and Christian Carpéné
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 555-566; DOI: https://doi.org/10.1124/jpet.119.259895

Gastrointestinal, Hepatic, Pulmonary, and Renal

  • Open Access
    A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models
    Joseph Kuo, Michael Bobardt, Udayan Chatterji, Patrick R. Mayo, Daniel J. Trepanier, Robert T. Foster, Philippe Gallay and Daren R. Ure
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 231-241; DOI: https://doi.org/10.1124/jpet.119.261099
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    Withaferin A Improves Nonalcoholic Steatohepatitis in Mice
    Daxesh P. Patel, Tingting Yan, Donghwan Kim, Henrique B. Dias, Kristopher W. Krausz, Shioko Kimura and Frank J. Gonzalez
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 360-374; DOI: https://doi.org/10.1124/jpet.119.256792

Metabolism, Transport, and Pharmacogenomics

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    Direct Measurement of Kinetic Parameters of ABCG2-Dependent Transport of Natural Flavonoids Using a Fluorogenic Substrate
    Michal Rozanski, Maciej Studzian and Lukasz Pulaski
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 309-319; DOI: https://doi.org/10.1124/jpet.119.261347
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    CC-115, a Dual Mammalian Target of Rapamycin/DNA-Dependent Protein Kinase Inhibitor in Clinical Trial, Is a Substrate of ATP-Binding Cassette G2, a Risk Factor for CC-115 Resistance
    Jenny Beebe and Jian-Ting Zhang
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 320-326; DOI: https://doi.org/10.1124/jpet.119.258392
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    A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcoholic Steatohepatitis on Hepatic Transporters in a Rat Model
    Michelle L. Montonye, Dan-Dan Tian, Tarana Arman, Katherine D. Lynch, Bruno Hagenbuch, Mary F. Paine and John D. Clarke
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 385-393; DOI: https://doi.org/10.1124/jpet.119.260489

Neuropharmacology

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    Streptozotocin-Induced Diabetic Neuropathic Pain Is Associated with Potentiated Calcium-Permeable AMPA Receptor Activity in the Spinal Cord
    Shao-Rui Chen, Jixiang Zhang, Hong Chen and Hui-Lin Pan
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 242-249; DOI: https://doi.org/10.1124/jpet.119.261339
  • Open Access
    Protection from Amyloid β Peptide–Induced Memory, Biochemical, and Morphological Deficits by a Phosphodiesterase-4D Allosteric Inhibitor
    Su-Ying Cui, Ming-Xin Yang, Yong-He Zhang, Victor Zheng, Han-Ting Zhang, Mark E. Gurney, Ying Xu and James M. O’Donnell
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 250-259; DOI: https://doi.org/10.1124/jpet.119.259986
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    Novel Adenosine Analog, N6-(4-Hydroxybenzyl)-Adenosine, Dampens Alcohol Drinking and Seeking Behaviors
    Sa-Ik Hong, Lee Peyton, Yijuang Chern and Doo-Sup Choi
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 260-267; DOI: https://doi.org/10.1124/jpet.119.261529
  • Open Access
    Age- and Sex-Specific Plasticity in Dopamine Transporter Function Revealed by Food Restriction and Exercise in a Rat Activity-Based Anorexia Paradigm
    T. Lee Gilman, W. Anthony Owens, Christina M. George, Lauren Metzel, Melissa Vitela, Livia Ferreira, Melodi A. Bowman, Georgianna G. Gould, Glenn M. Toney and Lynette C. Daws
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 268-277; DOI: https://doi.org/10.1124/jpet.119.260794
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    Differential Roles of Accumbal GSK3β in Cocaine versus Morphine-Induced Place Preference, U50,488H-Induced Place Aversion, and Object Memory
    Xiangdang Shi, Jeffrey L. Barr, Eva von Weltin, Cassandra Wolsh and Ellen M. Unterwald
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 339-347; DOI: https://doi.org/10.1124/jpet.119.259283
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    The Role of Dopamine D3 Receptor Partial Agonism in Cariprazine-Induced Neurotransmitter Efflux in Rat Hippocampus and Nucleus Accumbens
    Mei Huang, Wenqi He, Béla Kiss, Bence Farkas, Nika Adham and Herbert Y. Meltzer
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 517-525; DOI: https://doi.org/10.1124/jpet.119.259879
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    GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine
    Na-Ra Lee, Guangrong Zheng, Markos Leggas, Venumadhav Janganati, Justin R. Nickell, Peter A. Crooks, Michael T. Bardo and Linda P. Dwoskin
    Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 526-543; DOI: https://doi.org/10.1124/jpet.119.258699
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Journal of Pharmacology and Experimental Therapeutics: 371 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 371, Issue 2
1 Nov 2019
  • Table of Contents
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  • Special Section on The Opioid Crisis
  • Behavioral Pharmacology
  • Cardiovascular
  • Drug Discovery and Translational Medicine
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  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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