Simultaneous Assessment of Hepatic Transport and Metabolism Pathways with a Single Probe Using Individualized PBPK Modeling of 14CO2 Production Rate Data

Yoko Franchetti; Thomas D. Nolin

doi:10.1124/jpet.119.257212

Research ArticleMetabolism, Transport, and Pharmacogenomics

Simultaneous Assessment of Hepatic Transport and Metabolism Pathways with a Single Probe Using Individualized PBPK Modeling of ¹⁴CO₂ Production Rate Data

Yoko Franchetti and Thomas D. Nolin

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 151-161; DOI: https://doi.org/10.1124/jpet.119.257212

Yoko Franchetti

Departments of Pharmaceutical Sciences (Y.F.) and Pharmacy and Therapeutics (T.D.N.), Center of Clinical Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania

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Thomas D. Nolin

Departments of Pharmaceutical Sciences (Y.F.) and Pharmacy and Therapeutics (T.D.N.), Center of Clinical Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania

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Journal of Pharmacology and Experimental Therapeutics

Vol. 371, Issue 1

1 Oct 2019

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Research ArticleMetabolism, Transport, and Pharmacogenomics