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Research ArticleMetabolism, Transport, and Pharmacogenomics

Simultaneous Assessment of Hepatic Transport and Metabolism Pathways with a Single Probe Using Individualized PBPK Modeling of 14CO2 Production Rate Data

Yoko Franchetti and Thomas D. Nolin
Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 151-161; DOI: https://doi.org/10.1124/jpet.119.257212

Article Information

vol. 371 no. 1 151-161
DOI 
https://doi.org/10.1124/jpet.119.257212
PubMed 
31399494
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 21, 2019
  • Accepted July 31, 2019
  • Published online September 17, 2019.

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Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yoko Franchetti and
  2. Thomas D. Nolin
  1. Departments of Pharmaceutical Sciences (Y.F.) and Pharmacy and Therapeutics (T.D.N.), Center of Clinical Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania
  1. Address correspondence to:
    Dr. Thomas D. Nolin, Department of Pharmacy and Therapeutics, Center for Clinical Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 208 Salk Pavilion, 335 Sutherland Dr., Pittsburgh, PA 15261. E-mail: nolin{at}pitt.edu
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Research ArticleMetabolism, Transport, and Pharmacogenomics

PBPK Modeling to Assess Hepatic Pathways with a Single Probe

Yoko Franchetti and Thomas D. Nolin
Journal of Pharmacology and Experimental Therapeutics October 1, 2019, 371 (1) 151-161; DOI: https://doi.org/10.1124/jpet.119.257212
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