Journal of Pharmacology and Experimental Therapeutics: 371 (1)

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About the cover: SEP-856 does not exhibit significant occupancy at D2 receptors in non-human primates. See the article by Dedic et al., (dx.doi.org/10.1124/jpet.119.260281).

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Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
Functional Selectivity and Classical Concepts of Quantitative Pharmacology
Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

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