Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleSpecial Issue on Drug Delivery Technologies
Open Access

Nose-to-Brain Delivery

Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein and Ijeoma F. Uchegbu
Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 593-601; DOI: https://doi.org/10.1124/jpet.119.258152
Zian Wang
UCL School of Pharmacy, London, United Kingdom (Z.-a.W., G.X., W.C.T., A.G.S., I.F.U.); and Nanomerics, London, United Kingdom (A.G.S., I.F.U.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Guojun Xiong
UCL School of Pharmacy, London, United Kingdom (Z.-a.W., G.X., W.C.T., A.G.S., I.F.U.); and Nanomerics, London, United Kingdom (A.G.S., I.F.U.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wai Chun Tsang
UCL School of Pharmacy, London, United Kingdom (Z.-a.W., G.X., W.C.T., A.G.S., I.F.U.); and Nanomerics, London, United Kingdom (A.G.S., I.F.U.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andreas G. Schätzlein
UCL School of Pharmacy, London, United Kingdom (Z.-a.W., G.X., W.C.T., A.G.S., I.F.U.); and Nanomerics, London, United Kingdom (A.G.S., I.F.U.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ijeoma F. Uchegbu
UCL School of Pharmacy, London, United Kingdom (Z.-a.W., G.X., W.C.T., A.G.S., I.F.U.); and Nanomerics, London, United Kingdom (A.G.S., I.F.U.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The global prevalence of neurologic disorders is rising, and yet we are still unable to deliver most drug molecules, in therapeutic quantities, to the brain. The blood brain barrier consists of a tight layer of endothelial cells surrounded by astrocyte foot processes, and these anatomic features constitute a significant barrier to drug transport from the blood to the brain. One way to bypass the blood brain barrier and thus treat diseases of the brain is to use the nasal route of administration and deposit drugs at the olfactory region of the nares, from where they travel to the brain via mechanisms that are still not clearly understood, with travel across nerve fibers and travel via a perivascular pathway both being hypothesized. The nose-to-brain route has been demonstrated repeatedly in preclinical models, with both solution and particulate formulations. The nose-to-brain route has also been demonstrated in human studies with solution and particle formulations. The entry of device manufacturers into the arena will enable the benefits of this delivery route to become translated into approved products. The key factors that determine the efficacy of delivery via this route include the following: delivery to the olfactory area of the nares as opposed to the respiratory region, a longer retention time at the nasal mucosal surface, penetration enhancement of the active through the nasal epithelia, and a reduction in drug metabolism in the nasal cavity. Indications where nose-to-brain products are likely to emerge first include the following: neurodegeneration, post-traumatic stress disorder, pain, and glioblastoma.

Footnotes

    • Received March 17, 2019.
    • Accepted May 21, 2019.
  • https://doi.org/10.1124/jpet.119.258152.

  • Copyright © 2019 by The Author(s)

This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

View Full Text
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics: 370 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 370, Issue 3
1 Sep 2019
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Nose-to-Brain Delivery
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleSpecial Issue on Drug Delivery Technologies

Nose-to-Brain Delivery

Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein and Ijeoma F. Uchegbu
Journal of Pharmacology and Experimental Therapeutics September 1, 2019, 370 (3) 593-601; DOI: https://doi.org/10.1124/jpet.119.258152

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Research ArticleSpecial Issue on Drug Delivery Technologies

Nose-to-Brain Delivery

Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein and Ijeoma F. Uchegbu
Journal of Pharmacology and Experimental Therapeutics September 1, 2019, 370 (3) 593-601; DOI: https://doi.org/10.1124/jpet.119.258152
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CEA-Targeting Nanoparticles for CRC Treatment
  • Intranasal CSA in Nanoemulsion
  • Ultrasound-Triggered Combinational Therapy
Show more Special Issue on Drug Delivery Technologies

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics