Journal of Pharmacology and Experimental Therapeutics: 370 (3)

September 01, 2019; Volume 370,Issue 3

Special Issue on Drug Delivery Technologies

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Engineering Next-Generation Medicines: It’s All About Delivery
M.N.V. Ravi Kumar

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 528; DOI: https://doi.org/10.1124/jpet.119.258459
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Oral Drug Delivery Technologies—A Decade of Developments
G. Kaur, M. Arora and M.N.V. Ravi Kumar

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 529-543; DOI: https://doi.org/10.1124/jpet.118.255828
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Smart Drug Release from Medical Devices
Carmen Alvarez-Lorenzo and Angel Concheiro

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 544-554; DOI: https://doi.org/10.1124/jpet.119.257220
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Microneedle Coating Methods: A Review with a Perspective
Rohan S.J. Ingrole and Harvinder Singh Gill

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 555-569; DOI: https://doi.org/10.1124/jpet.119.258707
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Pharmacokinetic and Pharmacodynamic Properties of Drug Delivery Systems
Patrick M. Glassman and Vladimir R. Muzykantov

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 570-580; DOI: https://doi.org/10.1124/jpet.119.257113
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The Interplay Between Blood Proteins, Complement, and Macrophages on Nanomedicine Performance and Responses
S. Moein Moghimi, Dmitri Simberg, Tore Skotland, Anan Yaghmur and A. Christy Hunter

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 581-592; DOI: https://doi.org/10.1124/jpet.119.258012
Open Access
Nose-to-Brain Delivery
Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein and Ijeoma F. Uchegbu

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 593-601; DOI: https://doi.org/10.1124/jpet.119.258152
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Ocular Drug Delivery: Present Innovations and Future Challenges
Vrinda Gote, Sadia Sikder, Jeff Sicotte and Dhananjay Pal

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 602-624; DOI: https://doi.org/10.1124/jpet.119.256933
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Therapeutic Opportunities in Neuroblastoma Using Nanotechnology
Carlos Rodríguez-Nogales, Rosa Noguera, Patrick Couvreur and María J. Blanco-Prieto

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 625-635; DOI: https://doi.org/10.1124/jpet.118.255067
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Nanotechnology and Immunotherapy in Ovarian Cancer: Tracing New Landscapes
Bruna Corradetti, Simone Pisano, Robert Steven Conlan and Mauro Ferrari

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 636-646; DOI: https://doi.org/10.1124/jpet.118.254979
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Liposomal Nanostructures for Drug Delivery in Gastrointestinal Cancers
Manisit Das and Leaf Huang

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 647-656; DOI: https://doi.org/10.1124/jpet.118.254797
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Impact of CEA-targeting Nanoparticles for Drug Delivery in Colorectal Cancer
Ana Rita Sousa, Maria José Oliveira and Bruno Sarmento

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 657-670; DOI: https://doi.org/10.1124/jpet.118.254441
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Translating Nanomedicine to Comparative Oncology—the Case for Combining Zinc Oxide Nanomaterials with Nucleic Acid Therapeutic and Protein Delivery for Treating Metastatic Cancer
R.K. DeLong, Yi-Hsien Cheng, Paige Pearson, Zhoumeng Lin, Calli Coffee, Elza Neelima Mathew, Amanda Hoffman, Raelene M. Wouda and Mary Lynn Higginbotham

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 671-681; DOI: https://doi.org/10.1124/jpet.118.256230
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Combination Therapies and Drug Delivery Platforms in Combating Pancreatic Cancer
Fan Lei, Xinyuan Xi, Surinder K. Batra and Tatiana K. Bronich

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 682-694; DOI: https://doi.org/10.1124/jpet.118.255786
Open Access
Targeted Drug Delivery to Hepatic Stellate Cells for the Treatment of Liver Fibrosis
Zhijin Chen, Akshay Jain, Hao Liu, Zhen Zhao and Kun Cheng

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 695-702; DOI: https://doi.org/10.1124/jpet.118.256156
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Protein Chimerization: A New Frontier for Engineering Protein Therapeutics with Improved Pharmacokinetics
A. R. Satvik Iyengar, Shreya Gupta, Snehal Jawalekar and Abhay H. Pande

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 703-714; DOI: https://doi.org/10.1124/jpet.119.257063
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Poly(d,l-lactide-co-glycolide) Nanoparticles as Delivery Platforms for TLR7/8 Agonist-Based Cancer Vaccine
Hyunjoon Kim, Thomas S. Griffith and Jayanth Panyam

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 715-724; DOI: https://doi.org/10.1124/jpet.118.254953
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CRISPR/Cas System for Genome Editing: Progress and Prospects as a Therapeutic Tool
Deepak Kumar Sahel, Anupama Mittal and Deepak Chitkara

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 725-735; DOI: https://doi.org/10.1124/jpet.119.257287
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Injectable Pasty Biodegradable Polyesters Derived from Castor Oil and Hydroxyl-Acid Lactones
Noam Y. Steinman and Abraham J. Domb

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 736-741; DOI: https://doi.org/10.1124/jpet.119.259077
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Supersaturated Silica-Lipid Hybrid Oral Drug Delivery Systems: Balancing Drug Loading and In Vivo Performance
Hayley B. Schultz, Miia Kovalainen, Karl F. Peressin, Nicky Thomas and Clive A. Prestidge

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 742-750; DOI: https://doi.org/10.1124/jpet.118.254466
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Transient Receptor Potential Ion Channel–Dependent Toxicity of Silica Nanoparticles and Poly(amido amine) Dendrimers
Raziye Mohammadpour, Mostafa Yazdimamaghani, Christopher A. Reilly and Hamidreza Ghandehari

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 751-760; DOI: https://doi.org/10.1124/jpet.118.253682
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Long-Term Engraftment of Human Cardiomyocytes Combined with Biodegradable Microparticles Induces Heart Repair
Laura Saludas, Elisa Garbayo, Manuel Mazo, Beatriz Pelacho, Gloria Abizanda, Olalla Iglesias-Garcia, Angel Raya, Felipe Prósper and María J. Blanco-Prieto

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 761-771; DOI: https://doi.org/10.1124/jpet.118.256065
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Cellular Vesicles: New Insights in Engineering Methods, Interaction with Cells and Potential for Brain Targeting
A. Marazioti, K. Papadia, M. Kannavou, M. Spella, A. Basta, A.-L. de Lastic, M. Rodi, A. Mouzaki, M. Samiotaki, G. Panayotou, G.T. Stathopoulos and S.G. Antimisiaris

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 772-785; DOI: https://doi.org/10.1124/jpet.119.257097
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In Vivo Imaging of Small Molecular Weight Peptides for Targeted Renal Drug Delivery: A Study in Normal and Polycystic Kidney Diseased Mice
Stephen C. Lenhard, Allen McAlexander, Anthony Virtue, William Fieles, Tina Skedzielewski, Mary Rambo, Han Trinh, Shih-Hsun Cheng, Hyundae Hong, Albert Isidro-Llobet, Alan Nadin, Robert Geske, Jean-Louis Klein, Dennis Lee, Beat M. Jucker and Erding Hu

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 786-795; DOI: https://doi.org/10.1124/jpet.119.257022
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Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats
Davin Rautiola, Patricia D. Maglalang, Narsihmulu Cheryala, Kathryn M. Nelson, Gunda I. Georg, Jared M. Fine, Aleta L. Svitak, Katherine A. Faltesek, Leah R. Hanson, Usha Mishra, Lisa D. Coles, James C. Cloyd and Ronald A. Siegel

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 796-805; DOI: https://doi.org/10.1124/jpet.118.255943
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Prenatal Treatment of X-Linked Hypohidrotic Ectodermal Dysplasia Using Recombinant Ectodysplasin in a Canine Model
Carol A. Margolis, Pascal Schneider, Kenneth Huttner, Neil Kirby, Timothy P. Houser, Lee Wildman, Gary L. Grove, Holm Schneider and Margret L. Casal

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 806-813; DOI: https://doi.org/10.1124/jpet.118.256040
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Gellan Gum Based Sol-to-Gel Transforming System of Natamycin Transfersomes Improves Topical Ocular Delivery
Karthik Yadav Janga, Akshaya Tatke, Narendar Dudhipala, Sai Prachetan Balguri, Mohamed Moustafa Ibrahim, Doaa Nabih Maria, Monica M. Jablonski and Soumyajit Majumdar

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 814-822; DOI: https://doi.org/10.1124/jpet.119.256446
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δ-Tocopherol Effect on Endocytosis and Its Combination with Enzyme Replacement Therapy for Lysosomal Disorders: A New Type of Drug Interaction?
Rachel L. Manthe, Jeffrey A. Rappaport, Yan Long, Melani Solomon, Vinay Veluvolu, Michael Hildreth, Dencho Gugutkov, Juan Marugan, Wei Zheng and Silvia Muro

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 823-833; DOI: https://doi.org/10.1124/jpet.119.257345
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Microneedles Coated with Tramadol Exhibit Antinociceptive Effect in a Rat Model of Temporomandibular Hypernociception
Henrique Ballassini Abdalla, Amit K. Jain, Marcelo Henrique Napimoga, Juliana Trindade Clemente-Napimoga and Harvinder Singh Gill

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 834-842; DOI: https://doi.org/10.1124/jpet.119.256750
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CNS Delivery and Anti-Inflammatory Effects of Intranasally Administered Cyclosporine-A in Cationic Nanoformulations
Sunita Yadav, Grishma Pawar, Praveen Kulkarni, Craig Ferris and Mansoor Amiji

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 843-854; DOI: https://doi.org/10.1124/jpet.118.254672
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Single Dose of a Polyanhydride Particle-Based Vaccine Generates Potent Antigen-Specific Antitumor Immune Responses
Emad I. Wafa, Sean M. Geary, Kathleen A. Ross, Jonathan T. Goodman, Balaji Narasimhan and Aliasger K. Salem

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 855-863; DOI: https://doi.org/10.1124/jpet.118.252809
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Polymeric Micellar Delivery of Novel Microtubule Destabilizer and Hedgehog Signaling Inhibitor for Treating Chemoresistant Prostate Cancer
Ruinan Yang, Hao Chen, Dawei Guo, Yuxiang Dong, Duane D. Miller, Wei Li and Ram I. Mahato

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 864-875; DOI: https://doi.org/10.1124/jpet.119.256628
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Ultrasound-Triggered Spatiotemporal Delivery of Topotecan and Curcumin as Combination Therapy for Cancer
Chandrashekhar Prasad and Rinti Banerjee

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 876-893; DOI: https://doi.org/10.1124/jpet.119.256487
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A Polymeric Nanogel-Based Treatment Regimen for Enhanced Efficacy and Sequential Administration of Synergistic Drug Combination in Pancreatic Cancer
Kruti S. Soni, Divya Thomas, Thomas Caffrey, Kamiya Mehla, Fan Lei, Kelly A. O’Connell, Satish Sagar, Subodh M. Lele, Michael A. Hollingsworth, Prakash Radhakrishnan and Tatiana K. Bronich

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 894-901; DOI: https://doi.org/10.1124/jpet.118.255372
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Effectiveness of Small Interfering RNA Delivery via Arginine-Rich Polyethylenimine-Based Polyplex in Metastatic and Doxorubicin-Resistant Breast Cancer Cells
Shan Lu, Viola B. Morris and Vinod Labhasetwar

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 902-910; DOI: https://doi.org/10.1124/jpet.119.256909

Behavioral Pharmacology

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Discriminative Stimulus and Low Abuse Liability Effects of Novel Endomorphin Analogs Suggest a Potential Treatment Indication for Opioid Use Disorder
Mark R. Nilges, Morgan Laurent, Chloe Cable, Louis Arens, James Vafiades and James E. Zadina

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 369-379; DOI: https://doi.org/10.1124/jpet.118.253013
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The Effects of Morphine, Baclofen, and Buspirone Alone and in Combination on Schedule-Controlled Responding and Hot Plate Antinociception in Rats
Jenny L. Wilkerson, Jasmine S. Felix, Luis F. Restrepo, Mohd. Imran Ansari, Andrew Coop and Lance R. McMahon

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 380-389; DOI: https://doi.org/10.1124/jpet.118.255844

Cardiovascular

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Protein Kinase C Downregulation Enhanced Extracellular Ca²⁺-Induced Relaxation of Isolated Mesenteric Arteries from Aged Dahl Salt-Sensitive Rats
Samuel O. Odutola, Lakeesha E. Bridges and Emmanuel M. Awumey

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 427-435; DOI: https://doi.org/10.1124/jpet.119.258475
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Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4–Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1
Louisane Desbiens, Catherine Lapointe, Louis Gendron, Marjan Gharagozloo, Laurence Vincent, Gunnar Pejler, Denis Gris and Pedro D’Orléans-Juste

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 437-446; DOI: https://doi.org/10.1124/jpet.118.256016
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Liraglutide Attenuates Preestablished Atherosclerosis in Apolipoprotein E–Deficient Mice via Regulation of Immune Cell Phenotypes and Proinflammatory Mediators
Robyn Bruen, Seán Curley, Sarina Kajani, Gina Lynch, Marcella E. O’Reilly, Eugène T. Dillon, Eoin P. Brennan, Mary Barry, Stephen Sheehan, Fiona C. McGillicuddy and Orina Belton

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 447-458; DOI: https://doi.org/10.1124/jpet.119.258343

Cellular and Molecular

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Activation of HIF-1α by δ-Opioid Receptors Induces COX-2 Expression in Breast Cancer Cells and Leads to Paracrine Activation of Vascular Endothelial Cells
Alexandra Schoos, Cordula Gabriel, Vanessa M. Knab and Daniela A. Fux

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 480-489; DOI: https://doi.org/10.1124/jpet.119.257501
Open Access
Downregulation of TrkB Expression and Signaling by Valproic Acid and Other Histone Deacetylase Inhibitors
Simona Dedoni, Luisa Marras, Maria C. Olianas, Angela Ingianni and Pierluigi Onali

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 490-503; DOI: https://doi.org/10.1124/jpet.119.258129

Chemotherapy, Antibiotics, and Gene Therapy

Open Access
Radiosensitizing Effect of Novel Phenylpyrimidine Derivatives on Human Lung Cancer Cells via Cell Cycle Perturbation
Seung-Youn Jung, Ky-Youb Nam, Jeong-In Park, Kyung-Hee Song, Jiyeon Ahn, Jong Kuk Park, Hong-Duck Um, Sang-Gu Hwang, Sang Un Choi and Jie-Young Song

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 514-527; DOI: https://doi.org/10.1124/jpet.119.257717

Drug Discovery and Translational Medicine

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Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063
Sujay V. Kharade, Juan Vicente Sanchez-Andres, Mark G. Fulton, Elaine L. Shelton, Anna L. Blobaum, Darren W. Engers, Christopher S. Hofmann, Prasanna K. Dadi, Louise Lantier, David A. Jacobson, Craig W. Lindsley and Jerod S. Denton

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 350-359; DOI: https://doi.org/10.1124/jpet.119.257204
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TransCon CNP, a Sustained-Release C-Type Natriuretic Peptide Prodrug, a Potentially Safe and Efficacious New Therapeutic Modality for the Treatment of Comorbidities Associated with Fibroblast Growth Factor Receptor 3–Related Skeletal Dysplasias
Vibeke Miller Breinholt, Caroline E. Rasmussen, Per Holse Mygind, Mads Kjelgaard-Hansen, Frank Faltinger, Ana Bernhard, Joachim Zettler and Ulrich Hersel

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 459-471; DOI: https://doi.org/10.1124/jpet.119.258251

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium–Induced Colitis in Mice
Angela Sacco, Annalisa Bruno, Annalisa Contursi, Melania Dovizio, Stefania Tacconelli, Emanuela Ricciotti, Paloma Guillem-Llobat, Tania Salvatore, Luigia Di Francesco, Rosa Fullone, Patrizia Ballerini, Vincenzo Arena, Sara Alberti, Guizhu Liu, Yanjun Gong, Alessandro Sgambato, Carlo Patrono, Garret A. FitzGerald, Ying Yu and Paola Patrignani

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 416-426; DOI: https://doi.org/10.1124/jpet.119.259382
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Experimental Colitis Enhances the Rate of Antinociceptive Tolerance to Morphine via Peripheral Opioid Receptors
Essie Komla, David L. Stevens, Yi Zheng, Yan Zhang, William L. Dewey and Hamid I. Akbarali

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 504-513; DOI: https://doi.org/10.1124/jpet.119.256941

Metabolism, Transport, and Pharmacogenomics

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Antiretroviral Drug Concentrations in Lymph Nodes: A Cross-Species Comparison of the Effect of Drug Transporter Expression, Viral Infection, and Sex in Humanized Mice, Nonhuman Primates, and Humans
Erin Burgunder, John K. Fallon, Nicole White, Amanda P. Schauer, Craig Sykes, Leila Remling-Mulder, Martina Kovarova, Lourdes Adamson, Paul Luciw, J. Victor Garcia, Ramesh Akkina, Philip C. Smith and Angela D.M. Kashuba

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 360-368; DOI: https://doi.org/10.1124/jpet.119.259150
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Adenosine Deaminases Acting on RNA Downregulate the Expression of Constitutive Androstane Receptor in the Human Liver–Derived Cells by Attenuating Splicing
Masataka Nakano, Tatsuki Fukami and Miki Nakajima

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 408-415; DOI: https://doi.org/10.1124/jpet.119.260109

Neuropharmacology

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Target Engagement of a Phosphodiesterase 2A Inhibitor Affecting Long-Term Memory in the Rat
Guibao Gu, Trevor Scott, Yingzhuo Yan, Noelle Warren, Adia Zhang, Ali Tabatabaei, Hao Xu, Kathleen Aertgeerts, Laurent Gomez, Andrew Morse, Yu-Wen Li, J. Guy Breitenbucher, Eben Massari, Jeffrey Vivian and Anne Danks

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 399-407; DOI: https://doi.org/10.1124/jpet.118.255851
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Implication of K_v7 Channels in the Spinal Antinociceptive Actions of Celecoxib
Jorge Vicente-Baz, Jose A. Lopez-Garcia and Ivan Rivera-Arconada

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 472-479; DOI: https://doi.org/10.1124/jpet.119.258053

Toxicology

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Binge Alcohol Is More Injurious to Liver in Female than in Male Rats: Histopathological, Pharmacologic, and Epigenetic Profiles
Shivendra D. Shukla, Ricardo Restrepo, Annayya R. Aroor, Xuanyou Liu, Robert W. Lim, Jacob D. Franke, David A. Ford and Ronald J. Korthuis

Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 390-398; DOI: https://doi.org/10.1124/jpet.119.258871

Erratum

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Correction to “Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part II: Sex Differences in Methylprednisolone Pharmacokinetics and Corticosterone Suppression”
Journal of Pharmacology and Experimental Therapeutics September 2019, 370 (3) 436; DOI: https://doi.org/10.1124/jpet.118.257527err

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Table of Contents

Special Issue on Drug Delivery Technologies

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Erratum

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