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Research ArticleMetabolism, Transport, and Pharmacogenomics

Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part II: Sex Differences in Methylprednisolone Pharmacokinetics and Corticosterone Suppression

Vivaswath S. Ayyar, Debra C. DuBois, Toshimichi Nakamura, Richard R. Almon and William J. Jusko
Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 327-336; DOI: https://doi.org/10.1124/jpet.119.257527
Vivaswath S. Ayyar
Departments of Pharmaceutical Sciences (V.S.A., D.C.D., T.N., R.R.A., W.J.J.) and Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York; and DMPK Research Department, Teijin Institute for Biomedical Research, Teijin Pharma, Tokyo, Japan (T.N.)
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Debra C. DuBois
Departments of Pharmaceutical Sciences (V.S.A., D.C.D., T.N., R.R.A., W.J.J.) and Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York; and DMPK Research Department, Teijin Institute for Biomedical Research, Teijin Pharma, Tokyo, Japan (T.N.)
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Toshimichi Nakamura
Departments of Pharmaceutical Sciences (V.S.A., D.C.D., T.N., R.R.A., W.J.J.) and Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York; and DMPK Research Department, Teijin Institute for Biomedical Research, Teijin Pharma, Tokyo, Japan (T.N.)
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Richard R. Almon
Departments of Pharmaceutical Sciences (V.S.A., D.C.D., T.N., R.R.A., W.J.J.) and Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York; and DMPK Research Department, Teijin Institute for Biomedical Research, Teijin Pharma, Tokyo, Japan (T.N.)
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William J. Jusko
Departments of Pharmaceutical Sciences (V.S.A., D.C.D., T.N., R.R.A., W.J.J.) and Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York; and DMPK Research Department, Teijin Institute for Biomedical Research, Teijin Pharma, Tokyo, Japan (T.N.)
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Article Information

vol. 370 no. 2 327-336
DOI 
https://doi.org/10.1124/jpet.119.257527
PubMed 
31197019

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 15, 2019
  • Accepted June 10, 2019
  • Published online July 24, 2019.

Article Versions

  • Earlier version (June 13, 2019 - 07:45).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Vivaswath S. Ayyar,
  2. Debra C. DuBois,
  3. Toshimichi Nakamura,
  4. Richard R. Almon, and
  5. William J. Jusko
  1. Departments of Pharmaceutical Sciences (V.S.A., D.C.D., T.N., R.R.A., W.J.J.) and Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York; and DMPK Research Department, Teijin Institute for Biomedical Research, Teijin Pharma, Tokyo, Japan (T.N.)
  1. Address correspondence to:
    Dr. William J. Jusko, Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14214. E-mail: wjjusko{at}buffalo.edu
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Journal of Pharmacology and Experimental Therapeutics: 370 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 370, Issue 2
1 Aug 2019
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Research ArticleMetabolism, Transport, and Pharmacogenomics

Minimal PBPK-PD Modeling of Sex Differences in Methylprednisolone

Vivaswath S. Ayyar, Debra C. DuBois, Toshimichi Nakamura, Richard R. Almon and William J. Jusko
Journal of Pharmacology and Experimental Therapeutics August 1, 2019, 370 (2) 327-336; DOI: https://doi.org/10.1124/jpet.119.257527

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Research ArticleMetabolism, Transport, and Pharmacogenomics

Minimal PBPK-PD Modeling of Sex Differences in Methylprednisolone

Vivaswath S. Ayyar, Debra C. DuBois, Toshimichi Nakamura, Richard R. Almon and William J. Jusko
Journal of Pharmacology and Experimental Therapeutics August 1, 2019, 370 (2) 327-336; DOI: https://doi.org/10.1124/jpet.119.257527
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