Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleEndocrine and Diabetes
Open Access

SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity

Hikaru Ueno, Ryo Ito, Shin-ichi Abe, Mitsugi Ookawara, Hirohisa Miyashita, Hitomi Ogino, Yasufumi Miyamoto, Tomoki Yoshihara, Akihiro Kobayashi, Yoshiyuki Tsujihata, Koji Takeuchi, Masanori Watanabe, Yukio Yamada, Tsuyoshi Maekawa, Nobuhiro Nishigaki and Yusuke Moritoh
Journal of Pharmacology and Experimental Therapeutics August 2019, 370 (2) 172-181; DOI: https://doi.org/10.1124/jpet.118.255885
Hikaru Ueno
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ryo Ito
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shin-ichi Abe
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mitsugi Ookawara
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hirohisa Miyashita
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hitomi Ogino
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yasufumi Miyamoto
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tomoki Yoshihara
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Akihiro Kobayashi
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yoshiyuki Tsujihata
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Koji Takeuchi
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masanori Watanabe
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yukio Yamada
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tsuyoshi Maekawa
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nobuhiro Nishigaki
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: nobuhiro.nishigaki@takeda.com
Yusuke Moritoh
Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yusuke Moritoh
  • For correspondence: yusuke.moritoh@scohia.com
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF
Loading

Article Information

vol. 370 no. 2 172-181
DOI 
https://doi.org/10.1124/jpet.118.255885
PubMed 
31182471

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received December 26, 2018
  • Accepted April 1, 2019
  • Published online July 8, 2019.

Article Versions

  • Earlier version (June 10, 2019 - 07:27).
  • Earlier version (June 11, 2019 - 05:37).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2019 The Author(s). This is an open access article distributed under the CC BY Attribution 4.0 International license.

Author Information

  1. Hikaru Ueno,
  2. Ryo Ito,
  3. Shin-ichi Abe,
  4. Mitsugi Ookawara,
  5. Hirohisa Miyashita,
  6. Hitomi Ogino,
  7. Yasufumi Miyamoto,
  8. Tomoki Yoshihara,
  9. Akihiro Kobayashi,
  10. Yoshiyuki Tsujihata,
  11. Koji Takeuchi,
  12. Masanori Watanabe,
  13. Yukio Yamada,
  14. Tsuyoshi Maekawa,
  15. Nobuhiro Nishigaki⇑, and
  16. Yusuke Moritoh⇑
  1. Takeda Pharmaceutical Company Limited, Kanagawa, Japan (H.U., R.I., H.M., H.O., Y.Mi., T.Y., Y.T., K.T., N.N.); and SCOHIA PHARMA, Inc., Kanagawa, Japan (S.A., M.O., A.K., M.W., Y.Y., T.M., Y.Mo.)
  1. Address correspondence to:
    Yusuke Moritoh, Research and Development Division, SCOHIA PHARMA, Inc., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. E-mail: yusuke.moritoh{at}scohia.com; or
  2. Nobuhiro Nishigaki, Therapeutic Area General Medicine, Japan Medical Office, Takeda Pharmaceutical Company Limited. 1-1, Nihonbashi-Honcho 2-Chome, Chuo-ku, Tokyo 103-8686, Japan. E-mail: nobuhiro.nishigaki{at}takeda.com
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: June 2019 to February 2023

AbstractFullPdf
Jun 20196950221
Jul 2019207310146
Aug 201964396111
Sep 20194019953
Oct 20195515692
Nov 2019359941
Dec 20196412763
Jan 20203511655
Feb 20203910267
Mar 2020429557
Apr 20204110059
May 2020829166
Jun 20202910351
Jul 20205513772
Aug 2020249649
Sep 2020508238
Oct 20202611670
Nov 202011610755
Dec 20204011371
Jan 2021479457
Feb 2021209845
Mar 2021489445
Apr 2021486325
May 20213010850
Jun 2021117528
Jul 20211810267
Aug 20213710763
Sep 2021207058
Oct 202197743
Nov 2021136030
Dec 2021234334
Jan 2022185867
Feb 2022145431
Mar 202288230
Apr 202287543
May 2022107842
Jun 202292517
Jul 2022185715
Aug 2022444835
Sep 2022169059
Oct 2022264430
Nov 2022274227
Dec 202284013
Jan 2023433120
Feb 2023373

PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics: 370 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 370, Issue 2
1 Aug 2019
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleEndocrine and Diabetes

SCO-267, a GPR40 Full Agonist

Hikaru Ueno, Ryo Ito, Shin-ichi Abe, Mitsugi Ookawara, Hirohisa Miyashita, Hitomi Ogino, Yasufumi Miyamoto, Tomoki Yoshihara, Akihiro Kobayashi, Yoshiyuki Tsujihata, Koji Takeuchi, Masanori Watanabe, Yukio Yamada, Tsuyoshi Maekawa, Nobuhiro Nishigaki and Yusuke Moritoh
Journal of Pharmacology and Experimental Therapeutics August 1, 2019, 370 (2) 172-181; DOI: https://doi.org/10.1124/jpet.118.255885

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleEndocrine and Diabetes

SCO-267, a GPR40 Full Agonist

Hikaru Ueno, Ryo Ito, Shin-ichi Abe, Mitsugi Ookawara, Hirohisa Miyashita, Hitomi Ogino, Yasufumi Miyamoto, Tomoki Yoshihara, Akihiro Kobayashi, Yoshiyuki Tsujihata, Koji Takeuchi, Masanori Watanabe, Yukio Yamada, Tsuyoshi Maekawa, Nobuhiro Nishigaki and Yusuke Moritoh
Journal of Pharmacology and Experimental Therapeutics August 1, 2019, 370 (2) 172-181; DOI: https://doi.org/10.1124/jpet.118.255885
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • PF-5190457 metabolite activity at the ghrelin receptor
  • Insulin Inhibits Ubiquitination via USP14.
  • Characterization of a Novel Weekly Basal Insulin
Show more Endocrine and Diabetes

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics